Neurotrophin gene augmentation by electrotransfer to improve cochlear implant hearing outcomes - Pinyon, Jeremy L.; von Jonquieres, Georg; Crawford, Edward N.; Duxbury, Mayryl; Al Abed, Amr; Lovell, Nigel H.; Klugmann, Matthias; Wise, Andrew K.; Fallon, James B.; Shepherd, Robert K.; Birman, Catherine S.; Lai, Waikong; et al. (Hearing research, 2019)
Keywords: Animals; Auditory nerve fibre regeneration; Auditory Perception - genetics; Bionic array directed gene electrotransfer; Biotechnology; Brain derived neurotrophic factor; Cochlear Implantation - instrumentation; Cochlear Implants; Combined Modality Therapy; Electroporation; Gene therapy; Gene Transfer Techniques; Genetic Therapy; Hearing - genetics; Hearing Loss - genetics; Hearing Loss - physiopathology; Hearing Loss - psychology; Hearing Loss - rehabilitation; Human health and pathology; Humans; Life Sciences; Nerve Growth Factors - genetics; Neurotrophin-3; Persons with Hearing Disabilities - psychology; Persons with Hearing Disabilities - rehabilitation; Recovery of Function; Sensorineural hearing loss; Sensory Organs; Treatment Outcome; Up-Regulation; Neurotrophin-3; Brain derived neurotrophic factor; Auditory nerve fibre regeneration; Bionic array directed gene electrotransfer; Gene therapy; Sensorineural hearing loss; SURVIVAL; HAIR-CELLS; SPIRAL GANGLION NEURONS; INNER-EAR; THERAPY; INTRACOCHLEAR ELECTRICAL-STIMULATION; MOUSE MODEL; WORD RECOGNITION; EXPRESSION; DELIVERY