Bayesian hierarchical evaluation of dose-response for peanut allergy in clinical trial screening
Risk-based labeling based on the minimal eliciting doses (EDs) in sensitized populations is a potential replacement for precautionary allergen labeling of food allergens. We estimated the dose-response distribution for peanut allergen using data from double-blind placebo-controlled food challenges (...
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Published in | Food and chemical toxicology Vol. 151; p. 112125 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Ltd
01.05.2021
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Abstract | Risk-based labeling based on the minimal eliciting doses (EDs) in sensitized populations is a potential replacement for precautionary allergen labeling of food allergens. We estimated the dose-response distribution for peanut allergen using data from double-blind placebo-controlled food challenges (DBPCFCs) conducted in the US at multiple sites, testing a population believed to be similar to the general U.S. food allergic population. Our final (placebo-adjusted) dataset included 548 challenges of 481 subjects. Bayesian hierarchical analysis facilitated model fitting, and accounted for variability associated with various levels of data organization. The data are best described using a complex hierarchical structure that accounts for inter-individual variability and variability across study locations or substudies. Bayesian model averaging could simultaneously consider the fit of multiple models, but the Weibull model dominated so strongly that model averaging was not needed. The ED01 and ED05 (and 95% credible intervals) are 0.052 (0.021, 0.13) and 0.49 (0.22, 0.97) mg peanut protein, respectively. Accounting for challenges with severe reactions at the LOAEL, by using the dose prior to the LOAEL as the new LOAEL, the ED01 drops to 0.029 (0.014, 0.074) mg peanut protein. Our results could aid in establishing improved food labeling guidelines in the management of food allergies.
•Dose-response modeled for peanut DBPCFCs conducted using standardized protocols.•The study population was US adults and children from multiple geographic locations.•Repeated tests on the same individuals were moderately correlated, with some outliers.•Bayesian hierarchical analysis addressed inter-individual variability.•The calculated ED01 and ED05 were 0.052 and 0.49 mg peanut protein, respectively. |
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AbstractList | Risk-based labeling based on the minimal eliciting doses (EDs) in sensitized populations is a potential replacement for precautionary allergen labeling of food allergens. We estimated the dose-response distribution for peanut allergen using data from double-blind placebo-controlled food challenges (DBPCFCs) conducted in the US at multiple sites, testing a population believed to be similar to the general U.S. food allergic population. Our final (placebo-adjusted) dataset included 548 challenges of 481 subjects. Bayesian hierarchical analysis facilitated model fitting, and accounted for variability associated with various levels of data organization. The data are best described using a complex hierarchical structure that accounts for inter-individual variability and variability across study locations or substudies. Bayesian model averaging could simultaneously consider the fit of multiple models, but the Weibull model dominated so strongly that model averaging was not needed. The ED01 and ED05 (and 95% credible intervals) are 0.052 (0.021, 0.13) and 0.49 (0.22, 0.97) mg peanut protein, respectively. Accounting for challenges with severe reactions at the LOAEL, by using the dose prior to the LOAEL as the new LOAEL, the ED01 drops to 0.029 (0.014, 0.074) mg peanut protein. Our results could aid in establishing improved food labeling guidelines in the management of food allergies. Risk-based labeling based on the minimal eliciting doses (EDs) in sensitized populations is a potential replacement for precautionary allergen labeling of food allergens. We estimated the dose-response distribution for peanut allergen using data from double-blind placebo-controlled food challenges (DBPCFCs) conducted in the US at multiple sites, testing a population believed to be similar to the general U.S. food allergic population. Our final (placebo-adjusted) dataset included 548 challenges of 481 subjects. Bayesian hierarchical analysis facilitated model fitting, and accounted for variability associated with various levels of data organization. The data are best described using a complex hierarchical structure that accounts for inter-individual variability and variability across study locations or substudies. Bayesian model averaging could simultaneously consider the fit of multiple models, but the Weibull model dominated so strongly that model averaging was not needed. The ED01 and ED05 (and 95% credible intervals) are 0.052 (0.021, 0.13) and 0.49 (0.22, 0.97) mg peanut protein, respectively. Accounting for challenges with severe reactions at the LOAEL, by using the dose prior to the LOAEL as the new LOAEL, the ED01 drops to 0.029 (0.014, 0.074) mg peanut protein. Our results could aid in establishing improved food labeling guidelines in the management of food allergies. •Dose-response modeled for peanut DBPCFCs conducted using standardized protocols.•The study population was US adults and children from multiple geographic locations.•Repeated tests on the same individuals were moderately correlated, with some outliers.•Bayesian hierarchical analysis addressed inter-individual variability.•The calculated ED01 and ED05 were 0.052 and 0.49 mg peanut protein, respectively. |
ArticleNumber | 112125 |
Author | Allen, Bruce C. Sindher, Sayantani B. Haber, Lynne T. Chinthrajah, R. Sharon Reichard, John F. Vincent, Melissa J. Henning, Alice K. Dawson, Peter Nadeau, Kari C. Long, Andrew |
Author_xml | – sequence: 1 givenname: Lynne T. orcidid: 0000-0001-5384-642X surname: Haber fullname: Haber, Lynne T. email: Lynne.Haber@uc.edu organization: University of Cincinnati, Department of Environmental and Public Health Sciences, 160 Panzeca Way, Cincinnati, OH, 45267, USA – sequence: 2 givenname: John F. surname: Reichard fullname: Reichard, John F. organization: University of Cincinnati, Department of Environmental and Public Health Sciences, 160 Panzeca Way, Cincinnati, OH, 45267, USA – sequence: 3 givenname: Alice K. surname: Henning fullname: Henning, Alice K. organization: The Emmes Company, LLC, 401 North Washington St., Suite 700, Rockville, MD, 20850, USA – sequence: 4 givenname: Peter surname: Dawson fullname: Dawson, Peter organization: The Emmes Company, LLC, 401 North Washington St., Suite 700, Rockville, MD, 20850, USA – sequence: 5 givenname: R. Sharon surname: Chinthrajah fullname: Chinthrajah, R. Sharon organization: Sean N. Parker Center for Allergy and Asthma Research at Stanford University and Division of Pulmonary, Allergy, & Critical Care Medicine, Department of Medicine, Stanford, CA, USA – sequence: 6 givenname: Sayantani B. surname: Sindher fullname: Sindher, Sayantani B. organization: Sean N. Parker Center for Allergy and Asthma Research at Stanford University and Division of Pulmonary, Allergy, & Critical Care Medicine, Department of Medicine, Stanford, CA, USA – sequence: 7 givenname: Andrew surname: Long fullname: Long, Andrew organization: Sean N. Parker Center for Allergy and Asthma Research at Stanford University and Division of Pulmonary, Allergy, & Critical Care Medicine, Department of Medicine, Stanford, CA, USA – sequence: 8 givenname: Melissa J. orcidid: 0000-0002-0018-9662 surname: Vincent fullname: Vincent, Melissa J. organization: University of Cincinnati, Department of Environmental and Public Health Sciences, 160 Panzeca Way, Cincinnati, OH, 45267, USA – sequence: 9 givenname: Kari C. orcidid: 0000-0002-2146-2955 surname: Nadeau fullname: Nadeau, Kari C. organization: Sean N. Parker Center for Allergy and Asthma Research at Stanford University and Division of Pulmonary, Allergy, & Critical Care Medicine, Department of Medicine, Stanford, CA, USA – sequence: 10 givenname: Bruce C. orcidid: 0000-0003-1450-3955 surname: Allen fullname: Allen, Bruce C. organization: Independent Consultant, 101 Corbin Hill Circle, Chapel Hill, NC, 27514, USA |
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Cites_doi | 10.1016/j.jaci.2014.12.1917 10.1111/all.12614 10.1016/j.jaci.2016.08.017 10.1016/j.fct.2009.02.011 10.1016/j.fct.2020.111259 10.1016/j.jaci.2013.06.042 10.1111/insr.12243 10.1016/j.fct.2013.10.032 10.1016/j.jaci.2017.01.030 10.1016/j.jaci.2014.03.035 10.1016/j.jaip.2016.12.005 10.1016/j.jaci.2019.06.038 10.1007/s11222-016-9696-4 10.1016/j.jaci.2012.10.034 10.1016/j.yrtph.2020.104751 10.1016/j.fct.2014.01.032 10.1016/j.jaci.2019.07.046 10.1214/17-BA1091 10.1016/j.anai.2012.03.010 10.3389/fimmu.2018.02057 10.1111/j.1365-2222.2005.02312.x 10.1067/mai.2000.104941 10.1080/1744666X.2019.1582331 10.1016/j.jaci.2014.10.047 10.1111/all.13423 10.5740/jaoacint.17-0383 10.1034/j.1398-9995.2002.23797.x 10.1111/j.1399-3038.2010.01063.x 10.12688/f1000research.14450.1 10.1067/mai.2002.129235 10.1111/all.13405 10.1016/j.fct.2015.02.023 10.1016/j.jaci.2012.11.011 10.1016/j.fct.2020.111831 10.1016/j.fct.2009.12.013 10.1214/06-BA117A |
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Keywords | Bayesian hierarchical modeling Dose-response Interindividual variability Peanut allergy Risk assessment |
Language | English |
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References | Sicherer, Morrow, Sampson (bib30) 2000; 105 Vehtari, Gelman, Gabry (bib35) 2017; 27 Allen, Remington, Baumert, Crevel, Houben, Brooke-Taylor, Kruizinga, Taylor (bib2) 2014; 133 Eller, Hansen, Bindslev-Jensen (bib16) 2012; 108 Crevel, Baumert, Baka, Houben, Knulst, Kruizinga, Luccioli, Taylor, Madsen (bib12) 2014; 67 Blumchen, Beder, Beschorner, Ahrens, Gruebl, Hamelmann, Hansen, Heinzmann, Nemat, Niggemann, Wahn (bib6) 2014; 134 Gelman (bib19) 2006; 1 Allergen Bureau (bib3) 2020 Taylor, Baumert, Kruizinga, Remington, Crevel, Brooke-Taylor, Allen, of Australia, Houben (bib32) 2014; 63 Remington, Westerhout, Meima, Blom, Kruizinga, Wheeler, Taylor, Houben, Baumert (bib29) 2020 Agyemang, Sicherer (bib1) 2019; 15 Sjogren Bolin (bib31) 2015 Yao, Vehtari, Simpson, Gelman (bib41) 2018; 13 Hourihane, Allen, Shreffler, Dunngalvin, Nordlee, Zurzolo, Dunngalvin, Gurrin, Baumert, Taylor (bib21) 2017; 139 Hourihane, Grimshaw, Lewis, Briggs, Trewin, King, Kilburn, Warner (bib22) 2005; 35 Bindslev-Jensen, Briggs, Osterballe (bib7) 2002; 57 Wensing, Penninks, Hefle, Koppelman, Bruijnzeel-Koomen, Knulst (bib38) 2002; 110 Houben, Baumert, Blom, Kruizinga, Meima, Remington, Wheeler, Westerhout, Taylor (bib20) 2020; 146 Purington, Chinthrajah, Long, Sindher, Andorf, O'Laughlin, Woch, Scheiber, Assa'Ad, Pongracic, Spergel (bib28) 2018; 9 Zhu, Pouillot, Kwegyir-Afful, Luccioli, Gendel (bib42) 2015; 80 Allergen Bureau (bib4) 2019 Pettersson, Koppelman, Flokstra-de Blok, Kollen, Dubois (bib27) 2018; 73 Burks, Wood, Jones, Sicherer, Fleischer, Scurlock, Vickery, Liu, Henning, Lindblad, Dawson (bib11) 2015; 135 Dua, Ruiz-Garcia, Bond, Durham, Kimber, Mills, Roberts, Skypala, Wason, Ewan, Boyle (bib13) 2019; 144 Kusari, Han, Eichenfield (bib24) 2018; 7 Wainstein, Studdert, Ziegler, Ziegler (bib37) 2010; 21 Wheeler, Westerhout, Baumert, Remington (bib40) 2020; 13585 Blankestijn, Remington, Houben, Baumert, Knulst, Blom, Klemans, Taylor (bib9) 2017; 5 Blom, Vlieg-Boerstra, Kruizinga, van der Heide, Houben, Dubois (bib10) 2013; 131 Fleischer, Burks, Vickery, Scurlock, Wood, Jones, Sicherer, Liu, Stablein, Henning, Mayer (bib17) 2013; 131 Westerhout, Baumert, Blom, Allen, Ballmer-Weber, Crevel, Dubois, Fernández-Rivas, Greenhawt, Hourihane, Koplin (bib39) 2019; 144 (bib26) 2017 Jones, Sicherer, Burks, Leung, Lindblad, Dawson, Henning, Berin, Chiang, Vickery, Pesek (bib23) 2017; 139 Taylor, Crevel, Sheffield, Kabourek, Baumert (bib34) 2009; 47 DunnGalvin, Chan, Crevel, Grimshaw, Poms, Schnadt, Taylor, Turner, Allen, Austin, Baka (bib15) 2015; 70 Waiblinger, Schulze (bib36) 2018; 101 Fragoso, Bertoli, Louzada (bib18) 2018; 86 Ballmer-Weber, Fernandez-Rivas, Beyer, Defernez, Sperrin, Mackie, Salt, Hourihane, Asero, Belohlavkova, Kowalski (bib5) 2015; 135 Dubois, Turner, Hourihane, Ballmer-Weber, Beyer, Chan, Gowland, O'Hagan, Regent, Remington, Schnadt, Stroheker, Crevel (bib14) 2018; 73 Madsen, van den Dungen, Cochrane, Houben, Knibb, Knulst, Ronsmans, Yarham, Schnadt, Turner, Baumert (bib25) 2020; 117 Taylor, Moneret-Vautrin, Crevel, Sheffield, Morisset, Dumont, Remington, Baumert (bib33) 2010; 48 Blom (10.1016/j.fct.2021.112125_bib10) 2013; 131 (10.1016/j.fct.2021.112125_bib26) 2017 Waiblinger (10.1016/j.fct.2021.112125_bib36) 2018; 101 Allergen Bureau (10.1016/j.fct.2021.112125_bib4) Crevel (10.1016/j.fct.2021.112125_bib12) 2014; 67 Dubois (10.1016/j.fct.2021.112125_bib14) 2018; 73 Madsen (10.1016/j.fct.2021.112125_bib25) 2020; 117 Allen (10.1016/j.fct.2021.112125_bib2) 2014; 133 Westerhout (10.1016/j.fct.2021.112125_bib39) 2019; 144 Wheeler (10.1016/j.fct.2021.112125_bib40) 2020; 13585 Jones (10.1016/j.fct.2021.112125_bib23) 2017; 139 Blankestijn (10.1016/j.fct.2021.112125_bib9) 2017; 5 Taylor (10.1016/j.fct.2021.112125_bib33) 2010; 48 Wensing (10.1016/j.fct.2021.112125_bib38) 2002; 110 Fleischer (10.1016/j.fct.2021.112125_bib17) 2013; 131 Hourihane (10.1016/j.fct.2021.112125_bib21) 2017; 139 Yao (10.1016/j.fct.2021.112125_bib41) 2018; 13 Blumchen (10.1016/j.fct.2021.112125_bib6) 2014; 134 Dua (10.1016/j.fct.2021.112125_bib13) 2019; 144 Remington (10.1016/j.fct.2021.112125_bib29) 2020 Sicherer (10.1016/j.fct.2021.112125_bib30) 2000; 105 DunnGalvin (10.1016/j.fct.2021.112125_bib15) 2015; 70 Allergen Bureau (10.1016/j.fct.2021.112125_bib3) Pettersson (10.1016/j.fct.2021.112125_bib27) 2018; 73 Wainstein (10.1016/j.fct.2021.112125_bib37) 2010; 21 Fragoso (10.1016/j.fct.2021.112125_bib18) 2018; 86 Hourihane (10.1016/j.fct.2021.112125_bib22) 2005; 35 Burks (10.1016/j.fct.2021.112125_bib11) 2015; 135 Eller (10.1016/j.fct.2021.112125_bib16) 2012; 108 Houben (10.1016/j.fct.2021.112125_bib20) 2020; 146 Gelman (10.1016/j.fct.2021.112125_bib19) 2006; 1 Purington (10.1016/j.fct.2021.112125_bib28) 2018; 9 Bindslev-Jensen (10.1016/j.fct.2021.112125_bib7) 2002; 57 Kusari (10.1016/j.fct.2021.112125_bib24) 2018; 7 Ballmer-Weber (10.1016/j.fct.2021.112125_bib5) 2015; 135 Sjogren Bolin (10.1016/j.fct.2021.112125_bib31) 2015 Taylor (10.1016/j.fct.2021.112125_bib32) 2014; 63 Agyemang (10.1016/j.fct.2021.112125_bib1) 2019; 15 Taylor (10.1016/j.fct.2021.112125_bib34) 2009; 47 Vehtari (10.1016/j.fct.2021.112125_bib35) 2017; 27 Zhu (10.1016/j.fct.2021.112125_bib42) 2015; 80 |
References_xml | – volume: 21 start-page: 603 year: 2010 end-page: 611 ident: bib37 article-title: Prediction of anaphylaxis during peanut food challenge: usefulness of the peanut skin prick test (SPT) and specific IgE level publication-title: Pediatr. Allergy Immunol. contributor: fullname: Ziegler – volume: 135 start-page: 964 year: 2015 end-page: 971 ident: bib5 article-title: How much is too much? Threshold dose distributions for 5 food allergens publication-title: J. Allergy Clin. Immunol. contributor: fullname: Kowalski – volume: 144 start-page: 1584 year: 2019 end-page: 1594 ident: bib13 article-title: The effect of sleep deprivation and exercise on reaction threshold in peanut-allergic adults: a randomized controlled study publication-title: J. Allergy Clin. Immunol. contributor: fullname: Boyle – volume: 7 start-page: 1716 year: 2018 ident: bib24 article-title: Recent advances in understanding and preventing peanut and tree nut hypersensitivity publication-title: F1000Research contributor: fullname: Eichenfield – volume: 13 start-page: 917 year: 2018 end-page: 1007 ident: bib41 article-title: Using stacking to average Bayesian predictive distributions (with discussion) publication-title: Bayesian Analysis contributor: fullname: Gelman – volume: 110 start-page: 915 year: 2002 end-page: 920 ident: bib38 article-title: The distribution of individual threshold doses eliciting allergic reactions in a population with peanut allergy publication-title: J. Allergy Clin. Immunol. contributor: fullname: Knulst – volume: 70 start-page: 1039 year: 2015 end-page: 1051 ident: bib15 article-title: Precautionary allergen labelling: perspectives from key stakeholder groups publication-title: Allergy contributor: fullname: Baka – volume: 108 start-page: 332 year: 2012 end-page: 336 ident: bib16 article-title: Clinical thresholds to egg, hazelnut, milk and peanut: results from a single-center study using standardized challenges publication-title: Ann. Allergy Asthma Immunol. contributor: fullname: Bindslev-Jensen – volume: 144 start-page: 1290 year: 2019 end-page: 1309 ident: bib39 article-title: Deriving individual threshold doses from clinical food challenge data for population risk assessment of food allergens publication-title: J. Allergy Clin. Immunol. contributor: fullname: Koplin – year: 2020 ident: bib3 article-title: The VITAL® program contributor: fullname: Allergen Bureau – volume: 133 start-page: 156 year: 2014 end-page: 164 ident: bib2 article-title: Allergen reference doses for precautionary labeling (VITAL 2.0): clinical implications publication-title: J. Allergy Clin. Immunol. contributor: fullname: Taylor – volume: 117 start-page: 104751 year: 2020 ident: bib25 article-title: Can we define a level of protection for allergic consumers that everyone can accept? publication-title: Regul. Toxicol. Pharmacol. contributor: fullname: Baumert – volume: 135 start-page: 1240 year: 2015 end-page: 1248 ident: bib11 article-title: Sublingual immunotherapy for peanut allergy: long-term follow-up of a randomized multicenter trial publication-title: J. Allergy Clin. Immunol. contributor: fullname: Dawson – volume: 48 start-page: 814 year: 2010 end-page: 819 ident: bib33 article-title: Threshold dose for peanut: risk characterization based upon diagnostic oral challenge of a series of 286 peanut-allergic individuals publication-title: Food Chem. Toxicol. contributor: fullname: Baumert – volume: 9 start-page: 2057 year: 2018 ident: bib28 article-title: Eliciting dose and safety outcomes from a large dataset of standardized multiple food challenges publication-title: Front. Immunol. contributor: fullname: Spergel – year: 2019 ident: bib4 article-title: Summary of the 2019 VITAL scientific expert panel recommendations contributor: fullname: Allergen Bureau – volume: 73 start-page: 1383 year: 2018 end-page: 1392 ident: bib14 article-title: How does dose impact on the severity of food-induced allergic reactions, and can this improve risk assessment for allergenic foods?: report from an ILSI Europe Food Allergy Task Force Expert Group and Workshop publication-title: Allergy contributor: fullname: Crevel – volume: 47 start-page: 1198 year: 2009 end-page: 1204 ident: bib34 article-title: Threshold dose for peanut: risk characterization based upon published results from challenges of peanut-allergic individuals publication-title: Food Chem. Toxicol. contributor: fullname: Baumert – volume: 13585 year: 2020 ident: bib40 article-title: Bayesian Stacked parametric survival with frailty components and interval-censored failure times publication-title: Risk Anal. risa contributor: fullname: Remington – volume: 131 start-page: 119 year: 2013 end-page: 127 ident: bib17 article-title: Sublingual immunotherapy for peanut allergy: a randomized, double-blind, placebo-controlled multicenter trial publication-title: J. Allergy Clin. Immunol. contributor: fullname: Mayer – volume: 105 start-page: 582 year: 2000 end-page: 586 ident: bib30 article-title: Dose-response in double-blind, placebo-controlled oral food challenges in children with atopic dermatitis publication-title: J. Allergy Clin. Immunol. contributor: fullname: Sampson – volume: 146 start-page: 111831 year: 2020 ident: bib20 article-title: Full range of population Eliciting Dose values for 14 priority allergenic foods and recommendations for use in risk characterization publication-title: Food Chem. Toxicol. contributor: fullname: Taylor – volume: 86 start-page: 1 year: 2018 end-page: 28 ident: bib18 article-title: Bayesian model averaging: a systematic review and conceptual classification publication-title: Int. Stat. Rev. contributor: fullname: Louzada – volume: 67 start-page: 262 year: 2014 end-page: 276 ident: bib12 article-title: Development and evolution of risk assessment for food allergens publication-title: Food Chem. Toxicol. contributor: fullname: Madsen – year: 2017 ident: bib26 article-title: Finding a Path to Safety in Food Allergy: Assessment of the Global Burden, Causes, Prevention, Management, and Public Policy – volume: 27 start-page: 1413 year: 2017 end-page: 1432 ident: bib35 article-title: Practical Bayesian model evaluation using leave-one-out cross-validation and WAIC publication-title: Stat. Comput. contributor: fullname: Gabry – volume: 15 start-page: 487 year: 2019 end-page: 495 ident: bib1 article-title: The importance of early peanut ingestion in the prevention of peanut allergy publication-title: Expet Rev. Clin. Immunol. contributor: fullname: Sicherer – start-page: 111259 year: 2020 ident: bib29 article-title: Updated population minimal eliciting dose distributions for use in risk assessment of 14 priority food allergens publication-title: Food Chem. Toxicol. contributor: fullname: Baumert – volume: 80 start-page: 92 year: 2015 end-page: 100 ident: bib42 article-title: A retrospective analysis of allergic reaction severities and minimal eliciting doses for peanut, milk, egg, and soy oral food challenges publication-title: Food Chem. Toxicol. contributor: fullname: Gendel – volume: 139 start-page: 1583 year: 2017 end-page: 1590 ident: bib21 article-title: Peanut Allergen Threshold Study (PATS): novel single-dose oral food challenge study to validate eliciting doses in children with peanut allergy publication-title: J. Allergy Clin. Immunol. contributor: fullname: Taylor – year: 2015 ident: bib31 article-title: Undeclared milk , peanut , hazelnut or egg - guide on how to assess the risk of allergic reactions in the population. Livsmedelsverkets rapport 17/2015 publication-title: Livsmedelsverket Natl. Food Agency. contributor: fullname: Sjogren Bolin – volume: 134 start-page: 390 year: 2014 end-page: 398 ident: bib6 article-title: Modified oral food challenge used with sensitization biomarkers provides more real-life clinical thresholds for peanut allergy publication-title: J. Allergy Clin. Immunol. contributor: fullname: Wahn – volume: 5 start-page: 376 year: 2017 end-page: 380 ident: bib9 article-title: Threshold dose distribution in walnut allergy publication-title: J. Allergy Clin. Immunol.: In Pract. contributor: fullname: Taylor – volume: 57 start-page: 741 year: 2002 end-page: 746 ident: bib7 article-title: Can we determine a threshold level for allergenic foods by statistical analysis of published data in the literature? publication-title: Allergy contributor: fullname: Osterballe – volume: 73 start-page: 1532 year: 2018 end-page: 1540 ident: bib27 article-title: Prediction of the severity of allergic reactions to foods publication-title: Allergy contributor: fullname: Dubois – volume: 131 start-page: 172 year: 2013 end-page: 179 ident: bib10 article-title: Threshold dose distributions for 5 major allergenic foods in children publication-title: J. Allergy Clin. Immunol. contributor: fullname: Dubois – volume: 35 start-page: 1227 year: 2005 end-page: 1233 ident: bib22 article-title: Does severity of low‐dose, double‐blind, placebo‐controlled food challenges reflect severity of allergic reactions to peanut in the community? publication-title: Clin. Exp. Allergy contributor: fullname: Warner – volume: 139 start-page: 1242 year: 2017 end-page: 1252 ident: bib23 article-title: Epicutaneous immunotherapy for the treatment of peanut allergy in children and young adults publication-title: J. Allergy Clin. Immunol. contributor: fullname: Pesek – volume: 101 start-page: 17 year: 2018 end-page: 22 ident: bib36 article-title: Action levels for food allergens: an approach for official food control in Germany publication-title: J. AOAC Int. contributor: fullname: Schulze – volume: 63 start-page: 9 year: 2014 end-page: 17 ident: bib32 article-title: Establishment of reference doses for residues of allergenic foods: report of the VITAL expert panel publication-title: Food Chem. Toxicol. contributor: fullname: Houben – volume: 1 start-page: 515 year: 2006 end-page: 534 ident: bib19 article-title: Prior distributions for variance parameters in hierarchical models (comment on article by Browne and Draper) publication-title: Bayesian analysis contributor: fullname: Gelman – ident: 10.1016/j.fct.2021.112125_bib4 contributor: fullname: Allergen Bureau – volume: 135 start-page: 1240 issue: 5 year: 2015 ident: 10.1016/j.fct.2021.112125_bib11 article-title: Sublingual immunotherapy for peanut allergy: long-term follow-up of a randomized multicenter trial publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2014.12.1917 contributor: fullname: Burks – volume: 70 start-page: 1039 issue: 9 year: 2015 ident: 10.1016/j.fct.2021.112125_bib15 article-title: Precautionary allergen labelling: perspectives from key stakeholder groups publication-title: Allergy doi: 10.1111/all.12614 contributor: fullname: DunnGalvin – volume: 139 start-page: 1242 issue: 4 year: 2017 ident: 10.1016/j.fct.2021.112125_bib23 article-title: Epicutaneous immunotherapy for the treatment of peanut allergy in children and young adults publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2016.08.017 contributor: fullname: Jones – volume: 47 start-page: 1198 issue: 6 year: 2009 ident: 10.1016/j.fct.2021.112125_bib34 article-title: Threshold dose for peanut: risk characterization based upon published results from challenges of peanut-allergic individuals publication-title: Food Chem. Toxicol. doi: 10.1016/j.fct.2009.02.011 contributor: fullname: Taylor – start-page: 111259 year: 2020 ident: 10.1016/j.fct.2021.112125_bib29 article-title: Updated population minimal eliciting dose distributions for use in risk assessment of 14 priority food allergens publication-title: Food Chem. Toxicol. doi: 10.1016/j.fct.2020.111259 contributor: fullname: Remington – volume: 133 start-page: 156 issue: 1 year: 2014 ident: 10.1016/j.fct.2021.112125_bib2 article-title: Allergen reference doses for precautionary labeling (VITAL 2.0): clinical implications publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2013.06.042 contributor: fullname: Allen – volume: 86 start-page: 1 issue: 1 year: 2018 ident: 10.1016/j.fct.2021.112125_bib18 article-title: Bayesian model averaging: a systematic review and conceptual classification publication-title: Int. Stat. Rev. doi: 10.1111/insr.12243 contributor: fullname: Fragoso – volume: 63 start-page: 9 year: 2014 ident: 10.1016/j.fct.2021.112125_bib32 article-title: Establishment of reference doses for residues of allergenic foods: report of the VITAL expert panel publication-title: Food Chem. Toxicol. doi: 10.1016/j.fct.2013.10.032 contributor: fullname: Taylor – volume: 139 start-page: 1583 issue: 5 year: 2017 ident: 10.1016/j.fct.2021.112125_bib21 article-title: Peanut Allergen Threshold Study (PATS): novel single-dose oral food challenge study to validate eliciting doses in children with peanut allergy publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2017.01.030 contributor: fullname: Hourihane – year: 2017 ident: 10.1016/j.fct.2021.112125_bib26 – volume: 134 start-page: 390 issue: 2 year: 2014 ident: 10.1016/j.fct.2021.112125_bib6 article-title: Modified oral food challenge used with sensitization biomarkers provides more real-life clinical thresholds for peanut allergy publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2014.03.035 contributor: fullname: Blumchen – volume: 5 start-page: 376 issue: 2 year: 2017 ident: 10.1016/j.fct.2021.112125_bib9 article-title: Threshold dose distribution in walnut allergy publication-title: J. Allergy Clin. Immunol.: In Pract. doi: 10.1016/j.jaip.2016.12.005 contributor: fullname: Blankestijn – volume: 144 start-page: 1584 issue: 6 year: 2019 ident: 10.1016/j.fct.2021.112125_bib13 article-title: The effect of sleep deprivation and exercise on reaction threshold in peanut-allergic adults: a randomized controlled study publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2019.06.038 contributor: fullname: Dua – volume: 27 start-page: 1413 issue: 5 year: 2017 ident: 10.1016/j.fct.2021.112125_bib35 article-title: Practical Bayesian model evaluation using leave-one-out cross-validation and WAIC publication-title: Stat. Comput. doi: 10.1007/s11222-016-9696-4 contributor: fullname: Vehtari – volume: 131 start-page: 172 issue: 1 year: 2013 ident: 10.1016/j.fct.2021.112125_bib10 article-title: Threshold dose distributions for 5 major allergenic foods in children publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2012.10.034 contributor: fullname: Blom – volume: 117 start-page: 104751 year: 2020 ident: 10.1016/j.fct.2021.112125_bib25 article-title: Can we define a level of protection for allergic consumers that everyone can accept? publication-title: Regul. Toxicol. Pharmacol. doi: 10.1016/j.yrtph.2020.104751 contributor: fullname: Madsen – volume: 67 start-page: 262 year: 2014 ident: 10.1016/j.fct.2021.112125_bib12 article-title: Development and evolution of risk assessment for food allergens publication-title: Food Chem. Toxicol. doi: 10.1016/j.fct.2014.01.032 contributor: fullname: Crevel – volume: 144 start-page: 1290 issue: 5 year: 2019 ident: 10.1016/j.fct.2021.112125_bib39 article-title: Deriving individual threshold doses from clinical food challenge data for population risk assessment of food allergens publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2019.07.046 contributor: fullname: Westerhout – volume: 13 start-page: 917 issue: 3 year: 2018 ident: 10.1016/j.fct.2021.112125_bib41 article-title: Using stacking to average Bayesian predictive distributions (with discussion) publication-title: Bayesian Analysis doi: 10.1214/17-BA1091 contributor: fullname: Yao – volume: 108 start-page: 332 issue: 5 year: 2012 ident: 10.1016/j.fct.2021.112125_bib16 article-title: Clinical thresholds to egg, hazelnut, milk and peanut: results from a single-center study using standardized challenges publication-title: Ann. Allergy Asthma Immunol. doi: 10.1016/j.anai.2012.03.010 contributor: fullname: Eller – ident: 10.1016/j.fct.2021.112125_bib3 contributor: fullname: Allergen Bureau – volume: 13585 year: 2020 ident: 10.1016/j.fct.2021.112125_bib40 article-title: Bayesian Stacked parametric survival with frailty components and interval-censored failure times publication-title: Risk Anal. risa contributor: fullname: Wheeler – volume: 9 start-page: 2057 year: 2018 ident: 10.1016/j.fct.2021.112125_bib28 article-title: Eliciting dose and safety outcomes from a large dataset of standardized multiple food challenges publication-title: Front. Immunol. doi: 10.3389/fimmu.2018.02057 contributor: fullname: Purington – volume: 35 start-page: 1227 issue: 9 year: 2005 ident: 10.1016/j.fct.2021.112125_bib22 article-title: Does severity of low‐dose, double‐blind, placebo‐controlled food challenges reflect severity of allergic reactions to peanut in the community? publication-title: Clin. Exp. Allergy doi: 10.1111/j.1365-2222.2005.02312.x contributor: fullname: Hourihane – volume: 105 start-page: 582 issue: 3 year: 2000 ident: 10.1016/j.fct.2021.112125_bib30 article-title: Dose-response in double-blind, placebo-controlled oral food challenges in children with atopic dermatitis publication-title: J. Allergy Clin. Immunol. doi: 10.1067/mai.2000.104941 contributor: fullname: Sicherer – volume: 15 start-page: 487 issue: 5 year: 2019 ident: 10.1016/j.fct.2021.112125_bib1 article-title: The importance of early peanut ingestion in the prevention of peanut allergy publication-title: Expet Rev. Clin. Immunol. doi: 10.1080/1744666X.2019.1582331 contributor: fullname: Agyemang – volume: 135 start-page: 964 issue: 4 year: 2015 ident: 10.1016/j.fct.2021.112125_bib5 article-title: How much is too much? Threshold dose distributions for 5 food allergens publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2014.10.047 contributor: fullname: Ballmer-Weber – volume: 73 start-page: 1532 year: 2018 ident: 10.1016/j.fct.2021.112125_bib27 article-title: Prediction of the severity of allergic reactions to foods publication-title: Allergy doi: 10.1111/all.13423 contributor: fullname: Pettersson – volume: 101 start-page: 17 issue: 1 year: 2018 ident: 10.1016/j.fct.2021.112125_bib36 article-title: Action levels for food allergens: an approach for official food control in Germany publication-title: J. AOAC Int. doi: 10.5740/jaoacint.17-0383 contributor: fullname: Waiblinger – volume: 57 start-page: 741 issue: 8 year: 2002 ident: 10.1016/j.fct.2021.112125_bib7 article-title: Can we determine a threshold level for allergenic foods by statistical analysis of published data in the literature? publication-title: Allergy doi: 10.1034/j.1398-9995.2002.23797.x contributor: fullname: Bindslev-Jensen – volume: 21 start-page: 603 year: 2010 ident: 10.1016/j.fct.2021.112125_bib37 article-title: Prediction of anaphylaxis during peanut food challenge: usefulness of the peanut skin prick test (SPT) and specific IgE level publication-title: Pediatr. Allergy Immunol. doi: 10.1111/j.1399-3038.2010.01063.x contributor: fullname: Wainstein – volume: 7 start-page: 1716 year: 2018 ident: 10.1016/j.fct.2021.112125_bib24 article-title: Recent advances in understanding and preventing peanut and tree nut hypersensitivity publication-title: F1000Research doi: 10.12688/f1000research.14450.1 contributor: fullname: Kusari – volume: 110 start-page: 915 issue: 6 year: 2002 ident: 10.1016/j.fct.2021.112125_bib38 article-title: The distribution of individual threshold doses eliciting allergic reactions in a population with peanut allergy publication-title: J. Allergy Clin. Immunol. doi: 10.1067/mai.2002.129235 contributor: fullname: Wensing – volume: 73 start-page: 1383 issue: 7 year: 2018 ident: 10.1016/j.fct.2021.112125_bib14 article-title: How does dose impact on the severity of food-induced allergic reactions, and can this improve risk assessment for allergenic foods?: report from an ILSI Europe Food Allergy Task Force Expert Group and Workshop publication-title: Allergy doi: 10.1111/all.13405 contributor: fullname: Dubois – volume: 80 start-page: 92 year: 2015 ident: 10.1016/j.fct.2021.112125_bib42 article-title: A retrospective analysis of allergic reaction severities and minimal eliciting doses for peanut, milk, egg, and soy oral food challenges publication-title: Food Chem. Toxicol. doi: 10.1016/j.fct.2015.02.023 contributor: fullname: Zhu – year: 2015 ident: 10.1016/j.fct.2021.112125_bib31 article-title: Undeclared milk , peanut , hazelnut or egg - guide on how to assess the risk of allergic reactions in the population. Livsmedelsverkets rapport 17/2015 publication-title: Livsmedelsverket Natl. Food Agency. contributor: fullname: Sjogren Bolin – volume: 131 start-page: 119 issue: 1 year: 2013 ident: 10.1016/j.fct.2021.112125_bib17 article-title: Sublingual immunotherapy for peanut allergy: a randomized, double-blind, placebo-controlled multicenter trial publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2012.11.011 contributor: fullname: Fleischer – volume: 146 start-page: 111831 year: 2020 ident: 10.1016/j.fct.2021.112125_bib20 article-title: Full range of population Eliciting Dose values for 14 priority allergenic foods and recommendations for use in risk characterization publication-title: Food Chem. Toxicol. doi: 10.1016/j.fct.2020.111831 contributor: fullname: Houben – volume: 48 start-page: 814 issue: 3 year: 2010 ident: 10.1016/j.fct.2021.112125_bib33 article-title: Threshold dose for peanut: risk characterization based upon diagnostic oral challenge of a series of 286 peanut-allergic individuals publication-title: Food Chem. Toxicol. doi: 10.1016/j.fct.2009.12.013 contributor: fullname: Taylor – volume: 1 start-page: 515 issue: 3 year: 2006 ident: 10.1016/j.fct.2021.112125_bib19 article-title: Prior distributions for variance parameters in hierarchical models (comment on article by Browne and Draper) publication-title: Bayesian analysis doi: 10.1214/06-BA117A contributor: fullname: Gelman |
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