Sirtuin 1 is not required for contraction-stimulated glucose uptake in mouse skeletal muscle

• Published in: Journal of applied physiology (1985) Vol. 130; no. 6; pp. 1893 - 1902
• Main Authors: Kang, Ji Hyun, Park, Ji E, Dagoon, Jason, Masson, Stewart W C, Merry, Troy L, Bremner, Shannon N, Dent, Jessica R, Schenk, Simon
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.06.2021
• Subjects: Adaptation; Contraction; Deoxyglucose; Genotypes; Glucose; Males; Muscle contraction; Muscles; Musculoskeletal system; NAD; Perturbation; Sex; SIRT1 protein; Skeletal muscle; exercise; sex dimorphism; deacetylase; 2-deoxyglucose

While it has long been known that contraction robustly stimulates skeletal muscle glucose uptake, the molecular steps regulating this increase remain incompletely defined. The mammalian ortholog of Sir2, sirtuin 1 (SIRT1), is an NAD -dependent protein deacetylase that is thought to link perturbation...