Recoverability of freeze-dried doxorubicin-releasing chitosan embolic microspheres

• Published in: Journal of biomaterials science. Polymer ed. Vol. 24; no. 18; pp. 2081 - 2095
• Main Authors: Kim, Hyeongmin, Lee, Ga-Hyeon, Ro, Jieun, Kuh, Hyo-Jeong, Kwak, Byung-Kook, Lee, Jaehwi
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.12.2013
• Subjects: Animals; chemoembolization; Chitosan - chemistry; doxorubicin; Doxorubicin - analysis; Doxorubicin - chemistry; Doxorubicin - therapeutic use; elastic chitosan microsphere; Elasticity; Embolization, Therapeutic; Freeze Drying; freeze-drying excipient; Microspheres; recoverability; Trehalose - chemistry

The purpose of this study is to investigate the recoverability of freeze-dried chitosan microspheres (MS). The factors influencing the integrity of chitosan MS during freeze-drying and rehydration procedures were determined, with focusing on choosing a suitable rehydration method and a freeze-drying...