Recoverability of freeze-dried doxorubicin-releasing chitosan embolic microspheres
The purpose of this study is to investigate the recoverability of freeze-dried chitosan microspheres (MS). The factors influencing the integrity of chitosan MS during freeze-drying and rehydration procedures were determined, with focusing on choosing a suitable rehydration method and a freeze-drying...
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Published in | Journal of biomaterials science. Polymer ed. Vol. 24; no. 18; pp. 2081 - 2095 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Taylor & Francis
01.12.2013
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Abstract | The purpose of this study is to investigate the recoverability of freeze-dried chitosan microspheres (MS). The factors influencing the integrity of chitosan MS during freeze-drying and rehydration procedures were determined, with focusing on choosing a suitable rehydration method and a freeze-drying excipient. Mean MS size, size distribution and sphericity of recovered chitosan MS were evaluated. Furthermore, the impacts of freeze-drying and rehydration procedure on the elasticity of chitosan MS were explored and the release profiles were evaluated. The recoverability of lyophilized chitosan MS was largely dependent on rehydration method and freeze-drying excipients. When using the optimized recovery processes, deformable drug-loaded chitosan MS can be rapidly recovered to exhibit the initial physico-mechanical properties such as elasticity. Release profiles also were not significantly changed after rehydration procedure. It is therefore expected drug-loaded chitosan MS can be stably freeze-dried with the prevention of drug release during storage and rapidly recovered to be used as deformable embolic materials possibly applicable for anti-cancer embolotherapy. |
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AbstractList | The purpose of this study is to investigate the recoverability of freeze-dried chitosan microspheres (MS). The factors influencing the integrity of chitosan MS during freeze-drying and rehydration procedures were determined, with focusing on choosing a suitable rehydration method and a freeze-drying excipient. Mean MS size, size distribution and sphericity of recovered chitosan MS were evaluated. Furthermore, the impacts of freeze-drying and rehydration procedure on the elasticity of chitosan MS were explored and the release profiles were evaluated. The recoverability of lyophilized chitosan MS was largely dependent on rehydration method and freeze-drying excipients. When using the optimized recovery processes, deformable drug-loaded chitosan MS can be rapidly recovered to exhibit the initial physico-mechanical properties such as elasticity. Release profiles also were not significantly changed after rehydration procedure. It is therefore expected drug-loaded chitosan MS can be stably freeze-dried with the prevention of drug release during storage and rapidly recovered to be used as deformable embolic materials possibly applicable for anti-cancer embolotherapy. |
Author | Kim, Hyeongmin Ro, Jieun Lee, Jaehwi Kwak, Byung-Kook Lee, Ga-Hyeon Kuh, Hyo-Jeong |
Author_xml | – sequence: 1 givenname: Hyeongmin surname: Kim fullname: Kim, Hyeongmin organization: Pharmaceutical Formulation Design Laboratory, College of Pharmacy, Chung-Ang University – sequence: 2 givenname: Ga-Hyeon surname: Lee fullname: Lee, Ga-Hyeon organization: Pharmaceutical Formulation Design Laboratory, College of Pharmacy, Chung-Ang University – sequence: 3 givenname: Jieun surname: Ro fullname: Ro, Jieun organization: Pharmaceutical Formulation Design Laboratory, College of Pharmacy, Chung-Ang University – sequence: 4 givenname: Hyo-Jeong surname: Kuh fullname: Kuh, Hyo-Jeong organization: Department of Biomedical Science, College of Medicine, The Catholic University of Korea – sequence: 5 givenname: Byung-Kook surname: Kwak fullname: Kwak, Byung-Kook organization: Department of Radiology, Chung-Ang University Hospital – sequence: 6 givenname: Jaehwi surname: Lee fullname: Lee, Jaehwi email: jaehwi@cau.ac.kr organization: Pharmaceutical Formulation Design Laboratory, College of Pharmacy, Chung-Ang University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23909716$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1016_j_ijpharm_2016_07_028 crossref_primary_10_1016_j_ijbiomac_2019_11_122 crossref_primary_10_3390_polym13244307 |
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SubjectTerms | Animals chemoembolization Chitosan - chemistry doxorubicin Doxorubicin - analysis Doxorubicin - chemistry Doxorubicin - therapeutic use elastic chitosan microsphere Elasticity Embolization, Therapeutic Freeze Drying freeze-drying excipient Microspheres recoverability Trehalose - chemistry |
Title | Recoverability of freeze-dried doxorubicin-releasing chitosan embolic microspheres |
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