Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-β/SMAD signaling

• Published in: Oncotarget Vol. 6; no. 18; pp. 16352 - 16365
• Main Authors: Jiang, Hong-Lin, Sun, He-Fen, Gao, Shui-Ping, Li, Liang-Dong, Hu, Xin, Wu, Jiong, Jin, Wei
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 30.06.2015
• Subjects: Animals; Biomarkers, Tumor - genetics; Carcinoma, Ductal, Breast - genetics; Carcinoma, Ductal, Breast - mortality; Carcinoma, Ductal, Breast - pathology; Cell Line, Tumor; Cell Movement - genetics; Cell Proliferation - genetics; Down-Regulation; Enzyme Activation - genetics; Epithelial-Mesenchymal Transition - genetics; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Heterografts; Humans; Lung Neoplasms - secondary; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Neoplasm Transplantation; Prognosis; rab1 GTP-Binding Proteins - genetics; Receptors, Transforming Growth Factor beta - metabolism; Research Paper; RNA Interference; RNA, Small Interfering; Signal Transduction - genetics; Smad3 Protein - metabolism; Tissue Array Analysis; Transforming Growth Factor beta - metabolism; Triple Negative Breast Neoplasms - genetics; Triple Negative Breast Neoplasms - mortality; Triple Negative Breast Neoplasms - pathology; Ubiquitin - metabolism; TGF-β/SMAD signaling; triple-negative; RAB1B; metastatic breast cancer

Triple-negative breast cancer (TNBC) is a highly aggressive tumor subtype associated with a poor prognosis. The mechanism involved in TNBC progression remains largely unknown. To date, there are no effective therapeutic targets for this tumor subtype. In this study, by performing quantitative proteo...