Synthesis and characterization of amphiphilic PLA-(PαN3CL-g-PBA) copolymers by ring-opening polymerization and click reaction

• Published in: Polymer (Guilford) Vol. 53; no. 16; pp. 3476 - 3484
• Main Authors: Chiu, Fang-Chyou, Wang, Shiu-Wei, Peng, Kang-Yu, Lee, Ren-Shen
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 19.07.2012; Elsevier
• Subjects: Amphiphilic; Applied sciences; Block-graft functional polyester; cell viability; Click chemistry; composite polymers; Copolymerization; cytotoxicity; differential scanning calorimetry; drugs; Exact sciences and technology; hydrophobicity; micelles; Organic polymers; Physicochemistry of polymers; polyesters; polymerization; Preparation, kinetics, thermodynamics, mechanism and catalysts; sodium azide; sodium chloride; Block-graft functional polyester; Amphiphilic; Click chemistry; Biological properties; 1,3-Dipolar cycloaddition; Triazole derivative copolymer; Lactic acid copolymer; Indometacin; Propargylic compound; Chlorine containing copolymer; Cytotoxicity; Drug carrier; Nanoencapsulation; Micellar critical concentration; Release; Amphiphilic polymer; Lactone copolymer; Control release polymer; Experimental study; In vitro; Functional polymer; Non steroidal antiinflammatory agent; Azides; Benzoate; Monodispersed polymer; Chemical modification; Preparation; Diblock copolymer; Kinetics; Aqueous solution; Micellar solution; Nucleophilic substitution; Ring opening copolymerization; Aliphatic copolymer
• ISSN: 0032-3861; 1873-2291
• DOI: 10.1016/j.polymer.2012.06.004

The present study prepared novel amphiphilic block-graft PDLLA-b-(PαN3CL-g-PBA) and PLLA-b-(PαN3CL-g-PBA) functional polyesters, containing a hydrophilic poly(α-azido-ε-caprolactone-graft-alkyne) (PαN3CL-g-alkyne) segment and a hydrophobic poly(dl-lactide) (PDLLA) or poly(l-lactide) (PLLA) segment,...