Serum butyrylcholinesterase as a marker of COVID-19 mortality: Results of the monocentric prospective observational study
The COVID-19 pandemic represents an excessive burden on health care systems worldwide and the number of patients who require special care in the clinical setting is often hard to predict. Consequently, there is an unmet need for a reliable biomarker that could predict clinical outcomes of high-risk...
Saved in:
| Published in | Chemico-biological interactions Vol. 381; p. 110557 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Ireland
Elsevier B.V
25.08.2023
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The COVID-19 pandemic represents an excessive burden on health care systems worldwide and the number of patients who require special care in the clinical setting is often hard to predict. Consequently, there is an unmet need for a reliable biomarker that could predict clinical outcomes of high-risk patients. Lower serum butyrylcholinesterase (BChE) activity was recently linked with poor outcomes of COVID-19 patients. In line with this, our monocentric observational study on hospitalized COVID-19 patients focused on changes in serum BChE activity in relation to disease progression. Blood samples from 148 adult patients of both sexes were collected during their hospital stay at the Clinics of Infectiology and Clinics of Anesthesiology and Intensive Care, Trnava University Hospital in alignment with routine blood tests. Sera were analyzed using modified Ellman's method. Patient data with information about the health status, comorbidities and other blood parameters were collected in pseudonymized form. Our results show a lower serum BChE activity together with progressive decline of BChE activity in non-survivors, while higher stable values were present in discharged or transferred patients requiring further care. Lower BChE activity was associated with higher age and lower BMI. Moreover, we observed a negative correlation of serum BChE activity with the routinely used inflammatory markers, C-reactive protein and interleukin-6. Serum BChE activity mirrored clinical outcomes of COVID-19 patients and thus serves as a novel prognostic marker in high-risk patients.
•Progressive decline of butyrylcholinesterase is associated with COVID-19 mortality.•Serum BChE negatively correlates with C-reactive protein and IL-6.•Butyrylcholinesterase serves as a prognostic marker in critically ill patients useful for clinical practice. |
|---|---|
| AbstractList | The COVID-19 pandemic represents an excessive burden on health care systems worldwide and the number of patients who require special care in the clinical setting is often hard to predict. Consequently, there is an unmet need for a reliable biomarker that could predict clinical outcomes of high-risk patients. Lower serum butyrylcholinesterase (BChE) activity was recently linked with poor outcomes of COVID-19 patients. In line with this, our monocentric observational study on hospitalized COVID-19 patients focused on changes in serum BChE activity in relation to disease progression. Blood samples from 148 adult patients of both sexes were collected during their hospital stay at the Clinics of Infectiology and Clinics of Anesthesiology and Intensive Care, Trnava University Hospital in alignment with routine blood tests. Sera were analyzed using modified Ellman's method. Patient data with information about the health status, comorbidities and other blood parameters were collected in pseudonymized form. Our results show a lower serum BChE activity together with progressive decline of BChE activity in non-survivors, while higher stable values were present in discharged or transferred patients requiring further care. Lower BChE activity was associated with higher age and lower BMI. Moreover, we observed a negative correlation of serum BChE activity with the routinely used inflammatory markers, C-reactive protein and interleukin-6. Serum BChE activity mirrored clinical outcomes of COVID-19 patients and thus serves as a novel prognostic marker in high-risk patients. The COVID-19 pandemic represents an excessive burden on health care systems worldwide and the number of patients who require special care in the clinical setting is often hard to predict. Consequently, there is an unmet need for a reliable biomarker that could predict clinical outcomes of high-risk patients. Lower serum butyrylcholinesterase (BChE) activity was recently linked with poor outcomes of COVID-19 patients. In line with this, our monocentric observational study on hospitalized COVID-19 patients focused on changes in serum BChE activity in relation to disease progression. Blood samples from 148 adult patients of both sexes were collected during their hospital stay at the Clinics of Infectiology and Clinics of Anesthesiology and Intensive Care, Trnava University Hospital in alignment with routine blood tests. Sera were analyzed using modified Ellman's method. Patient data with information about the health status, comorbidities and other blood parameters were collected in pseudonymized form. Our results show a lower serum BChE activity together with progressive decline of BChE activity in non-survivors, while higher stable values were present in discharged or transferred patients requiring further care. Lower BChE activity was associated with higher age and lower BMI. Moreover, we observed a negative correlation of serum BChE activity with the routinely used inflammatory markers, C-reactive protein and interleukin-6. Serum BChE activity mirrored clinical outcomes of COVID-19 patients and thus serves as a novel prognostic marker in high-risk patients. •Progressive decline of butyrylcholinesterase is associated with COVID-19 mortality.•Serum BChE negatively correlates with C-reactive protein and IL-6.•Butyrylcholinesterase serves as a prognostic marker in critically ill patients useful for clinical practice. |
| ArticleNumber | 110557 |
| Author | Solavova, Maria Dingova, Dominika Javorova Rihova, Zuzana Martinkovicova, Anna Markuskova, Lucia Havrisko, Martina Hrabovska, Anna Rabarova, Daria Fazekas, Tomas |
| Author_xml | – sequence: 1 givenname: Lucia surname: Markuskova fullname: Markuskova, Lucia organization: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University Bratislava, Odbojarov 10, 832 32, Bratislava, Slovakia – sequence: 2 givenname: Zuzana surname: Javorova Rihova fullname: Javorova Rihova, Zuzana organization: Department of Pharmacology, Faculty of Medicine, Slovak Medical University Bratislava, Limbova 12, 832 03, Bratislava, Slovakia – sequence: 3 givenname: Tomas surname: Fazekas fullname: Fazekas, Tomas organization: Department of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University Bratislava, 832 32, Bratislava, Slovakia – sequence: 4 givenname: Anna surname: Martinkovicova fullname: Martinkovicova, Anna organization: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University Bratislava, Odbojarov 10, 832 32, Bratislava, Slovakia – sequence: 5 givenname: Martina surname: Havrisko fullname: Havrisko, Martina organization: Department of Clinical Pharmacology, Trnava University Hospital, A. Zarnova 11, 917 75, Trnava, Slovakia – sequence: 6 givenname: Dominika surname: Dingova fullname: Dingova, Dominika organization: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University Bratislava, Odbojarov 10, 832 32, Bratislava, Slovakia – sequence: 7 givenname: Maria surname: Solavova fullname: Solavova, Maria organization: Clinic of Infectiology, Trnava University Hospital, A. Zarnova 11, 917 75, Trnava, Slovakia – sequence: 8 givenname: Daria surname: Rabarova fullname: Rabarova, Daria organization: Clinic of Anesthesiology and Intensive Care, Trnava University Hospital, A. Zarnova 11, 917 75, Trnava, Slovakia – sequence: 9 givenname: Anna orcidid: 0000-0003-1713-872X surname: Hrabovska fullname: Hrabovska, Anna email: hrabovska@fpharm.uniba.sk organization: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University Bratislava, Odbojarov 10, 832 32, Bratislava, Slovakia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37209860$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kE1rGzEQhkVJaOy0P6CXomMv64y0n2pOxc2HIWBI0l6FpJ0lcndXrqQ17L-vjJMecxkxmnde5n2W5Gx0IxLyhcGKAauudiuj7YoDz1eMQVnWH8iCNTXP6rqpzsgCAETGa1FfkGUIu9QCL-AjuchrDqKpYEHmJ_TTQPUUZz_35sX1dsQQ0auAVAWq6KD8H_TUdXS9_b35mTFBB-ej6m2cv9NHDFMfw3EcXzBNRmdwjN4auvcu7NFEe0DqdEB_UNG6UfU0xKmdP5HzTvUBP7--l-TX7c3z-j572N5t1j8eMpOLKmaaFdBxKBUTGpXBTmiR_gTonGNhClZ0ohSq4qZtUGPOGQreCQVQplqa_JJ8O_mme_5OKZscbDDY92pENwXJG1bVFasET1J2kpp0evDYyb23Kf8sGcgjcbmTibg8Epcn4mnn66v9pAds_2-8IU6C65MAU8iDRS-DsTgabK1PdGTr7Dv2_wDS-5T3 |
| CitedBy_id | crossref_primary_10_3390_ijms242115879 crossref_primary_10_5493_wjem_v14_i1_87202 crossref_primary_10_7759_cureus_60417 |
| Cites_doi | 10.1016/j.mcpro.2022.100277 10.1016/j.pharmthera.2014.11.011 10.1016/0041-0101(94)90416-2 10.1016/S1473-3099(22)00223-7 10.1111/joim.13006 10.1016/S2665-9913(20)30420-3 10.1016/j.diabres.2005.08.009 10.1210/en.2004-0569 10.3892/br.2013.60 10.1161/CIRCULATIONAHA.120.047659 10.1016/j.isci.2022.104612 10.1016/j.mehy.2020.110274 10.1016/S0167-4943(00)00073-X 10.1016/S0140-6736(20)30183-5 10.1016/j.intimp.2022.109428 10.1016/j.mayocp.2021.06.023 10.1016/S1665-2681(19)30932-9 10.1016/j.burns.2020.10.027 10.1373/clinchem.2011.175984 10.3389/fmed.2022.940533 10.1007/s13539-012-0083-5 10.1016/j.fct.2021.112009 10.4269/ajtmh.21-0934 10.1097/CCM.0000000000005195 10.1073/pnas.1706517114 10.1113/JP280769 10.1016/j.jinf.2020.08.021 10.1016/j.atherosclerosis.2015.04.804 10.1007/BF01061095 10.1038/nature01339 10.3389/fimmu.2022.857573 10.1038/ijo.2017.123 10.1016/0021-9681(87)90171-8 10.2217/bem-2020-0010 10.1155/2018/1942193 10.3390/diagnostics12092150 10.1155/2015/274607 10.1016/S2589-7500(22)00112-1 10.1016/j.toxlet.2017.04.017 10.1016/j.ab.2014.05.031 10.1016/j.cbi.2016.02.013 10.1016/S0306-4522(01)00613-3 10.1007/s11606-020-05991-z |
| ContentType | Journal Article |
| Copyright | 2023 Elsevier B.V. Copyright © 2023 Elsevier B.V. All rights reserved. |
| Copyright_xml | – notice: 2023 Elsevier B.V. – notice: Copyright © 2023 Elsevier B.V. All rights reserved. |
| DBID | NPM AAYXX CITATION 7X8 |
| DOI | 10.1016/j.cbi.2023.110557 |
| DatabaseName | PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
| DatabaseTitleList | PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Chemistry Biology |
| EISSN | 1872-7786 |
| EndPage | 110557 |
| ExternalDocumentID | 10_1016_j_cbi_2023_110557 37209860 S0009279723002247 |
| Genre | Journal Article |
| GroupedDBID | --- --K --M -~X .~1 0R~ 1B1 1RT 1~. 1~5 29B 4.4 457 4G. 5GY 5RE 5VS 6J9 7-5 71M 8P~ 9JM AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AATCM AAXUO ABFRF ABFYP ABJNI ABLST ABMAC ABYKQ ABZDS ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE AEBSH AEFWE AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGUBO AGYEJ AHEUO AIEXJ AIKHN AITUG AJOXV AKIFW ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLECG BLXMC CS3 DU5 EBS EFJIC EFLBG EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA IHE J1W KCYFY KOM M34 M41 MO0 N9A O-L O9- OAUVE OGGZJ OZT P-8 P-9 P2P PC. Q38 ROL RPZ SCC SDF SDG SDP SES SEW SPCBC SSJ SSP SSZ T5K WH7 ~G- AAXKI AFJKZ AKRWK NPM RIG .GJ 0SF 3O- 53G AAQXK AAYJJ AAYXX ABEFU ABFNM ABXDB ADMUD ADVLN AFFNX AHHHB AI. ASPBG AVWKF AZFZN CITATION EJD FEDTE FGOYB G-2 HMT HVGLF HZ~ H~9 NCXOZ R2- SPT VH1 WUQ ZGI ZXP 7X8 |
| ID | FETCH-LOGICAL-c396t-b140f205a19beacef9b9b1490b32e4c414f959a62cd8ebe321e92f9a005f9a5c3 |
| IEDL.DBID | .~1 |
| ISSN | 0009-2797 |
| IngestDate | Fri Oct 25 09:34:19 EDT 2024 Thu Sep 26 17:32:18 EDT 2024 Wed Oct 16 00:39:42 EDT 2024 Fri Feb 23 02:37:56 EST 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | COVID-19 Biomarker SARS-CoV-2 C-reactive protein Butyrylcholinesterase Interleukin-6 |
| Language | English |
| License | Copyright © 2023 Elsevier B.V. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c396t-b140f205a19beacef9b9b1490b32e4c414f959a62cd8ebe321e92f9a005f9a5c3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 |
| ORCID | 0000-0003-1713-872X |
| OpenAccessLink | https://doi.org/10.1016/j.cbi.2023.110557 |
| PMID | 37209860 |
| PQID | 2816761692 |
| PQPubID | 23479 |
| PageCount | 1 |
| ParticipantIDs | proquest_miscellaneous_2816761692 crossref_primary_10_1016_j_cbi_2023_110557 pubmed_primary_37209860 elsevier_sciencedirect_doi_10_1016_j_cbi_2023_110557 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-08-25 |
| PublicationDateYYYYMMDD | 2023-08-25 |
| PublicationDate_xml | – month: 08 year: 2023 text: 2023-08-25 day: 25 |
| PublicationDecade | 2020 |
| PublicationPlace | Ireland |
| PublicationPlace_xml | – name: Ireland |
| PublicationTitle | Chemico-biological interactions |
| PublicationTitleAlternate | Chem Biol Interact |
| PublicationYear | 2023 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Battaglini, Lopes-Pacheco, Castro-Faria-Neto, Pelosi, Rocco (bib17) 2022; 13 Abou-Hatab, O'Mahony, Patel, Carey, Woodhouse (bib26) Dec. 2000; 31 Goliasch (bib34) 2012; 58 Zivkovic (bib31) Apr. 2018; 2018 Sattar, McInnes, McMurray (bib13) Jul. 2020; 142 Oda (bib29) Jul. 2015; 241 Wang (bib49) Jan. 2003; 421 Gong, Sankari (bib37) 2022 Santarpia, Grandone, Contaldo, Pasanisi (bib55) 2013; 4 Buyukozkan (bib14) Jul. 2022; 25 Asad, Przebinda, Chaudhary, Farooqui, Youness, Stavrakis (bib50) Dec. 2020; 3 Richard (bib15) Oct. 2022; 21 Sauver (bib10) Oct. 2021; 96 Bahloul (bib44) Sep. 2022; 107 Xin (bib11) Jan. 2023; 30 Schmidt (bib47) Jun. 2021; 47 Brock, Brock (bib53) Jan. 1993; 24 Christensen (bib59) 2020; 35 Meng, Yin, Ma, Guo, Jin, Li (bib54) 2013; 1 Nakajima (bib41) Feb. 2021; 82 Huang (bib1) Feb. 2020; 395 Sharma, Danckers, Sanghavi, Chakraborty (bib36) 2023 bib3 Nakajima (bib18) Feb. 2021; 82 Warren-Gash (bib12) Apr. 2023; 27 Comoglu, Kant (bib57) Apr. 2022; 9 bib2 Simonson (bib4) 2021; 599 Zhao (bib33) 2020; 32 Charlson, Pompei, Ales, MacKenzie (bib39) 1987; 40 Jbilo, Bartels, Chatonnet, Toutant, Lockridge (bib20) 1994; 32 Hickey, Giwa (bib38) 2023 Docherty (bib7) May 2020; 369 Nazerian, Ghasemi, Yassaghi, Nazerian, Hashemi (bib5) Dec. 2022; 113 Venkataraman, Iyer, Narayanan, Joseph (bib27) Jan. 1990; 34 (bib35) Jan. 2022 McGonagle, Bridgewood, Ramanan, Meaney, Watad (bib9) Mar. 2021; 3 Cox (bib52) 2020; 287 Lampón, Hermida-Cadahia, Riveiro, Tutor (bib32) May 2012; 11 Burn (bib8) 2022; 22 Brimijoin, Chen, Pang, Geng, Gao (bib30) Nov. 2016; 259 Dingova, Leroy, Check, Garaj, Krejci, Hrabovska (bib40) Oct. 2014; 462 Sipahioglu (bib42) 2022; 9 Karasova (bib25) Aug. 2017; 277 Chen, Gao, Geng, Brimijoin (bib24) 2017; 114 Lagoumintzis (bib51) Mar. 2021; 149 Chen, Gao, Geng, Brimijoin (bib23) 2017; 41 Byeon (bib16) Sep. 2022; 4 Inácio Lunkes, Stefanello, Sausen Lunkes, Maria Morsch, Schetinger, Gonçalves (bib28) Apr. 2006; 72 Mesulam, Guillozet, Shaw, Levey, Duysen, Lockridge (bib21) 2002; 110 Espeter (bib45) Sep. 2022; 12 Lockridge (bib19) Apr. 2015; 148 El-sayed, Mohamed, Ahmed, ElBagoury (bib56) 2019; 9 Türker (bib58) 2022; 15 Zivkovic, Schmidt, Sigl, Decker, Brenner, Hofer (bib46) Feb. 2015; 2015 De Vriese, Gregoire, Lema-Kisoka, Waelbroeck, Robberecht, Delporte (bib22) 2004; 145 Pomara, Imbimbo (bib48) Nov. 2020; 144 Bahloul (bib43) Nov. 2021; 37 Karakike (bib6) Dec. 2021; 49 Sauver (10.1016/j.cbi.2023.110557_bib10) 2021; 96 Battaglini (10.1016/j.cbi.2023.110557_bib17) 2022; 13 Zivkovic (10.1016/j.cbi.2023.110557_bib31) 2018; 2018 Charlson (10.1016/j.cbi.2023.110557_bib39) 1987; 40 Warren-Gash (10.1016/j.cbi.2023.110557_bib12) 2023; 27 Mesulam (10.1016/j.cbi.2023.110557_bib21) 2002; 110 Dingova (10.1016/j.cbi.2023.110557_bib40) 2014; 462 Christensen (10.1016/j.cbi.2023.110557_bib59) 2020; 35 Santarpia (10.1016/j.cbi.2023.110557_bib55) 2013; 4 Brimijoin (10.1016/j.cbi.2023.110557_bib30) 2016; 259 Gong (10.1016/j.cbi.2023.110557_bib37) 2022 Byeon (10.1016/j.cbi.2023.110557_bib16) 2022; 4 Burn (10.1016/j.cbi.2023.110557_bib8) 2022; 22 McGonagle (10.1016/j.cbi.2023.110557_bib9) 2021; 3 Jbilo (10.1016/j.cbi.2023.110557_bib20) 1994; 32 Docherty (10.1016/j.cbi.2023.110557_bib7) 2020; 369 Simonson (10.1016/j.cbi.2023.110557_bib4) 2021; 599 Zhao (10.1016/j.cbi.2023.110557_bib33) 2020; 32 Venkataraman (10.1016/j.cbi.2023.110557_bib27) 1990; 34 Wang (10.1016/j.cbi.2023.110557_bib49) 2003; 421 Nakajima (10.1016/j.cbi.2023.110557_bib41) 2021; 82 Bahloul (10.1016/j.cbi.2023.110557_bib44) 2022; 107 Chen (10.1016/j.cbi.2023.110557_bib23) 2017; 41 Meng (10.1016/j.cbi.2023.110557_bib54) 2013; 1 Brock (10.1016/j.cbi.2023.110557_bib53) 1993; 24 Huang (10.1016/j.cbi.2023.110557_bib1) 2020; 395 Oda (10.1016/j.cbi.2023.110557_bib29) 2015; 241 Lockridge (10.1016/j.cbi.2023.110557_bib19) 2015; 148 Goliasch (10.1016/j.cbi.2023.110557_bib34) 2012; 58 Hickey (10.1016/j.cbi.2023.110557_bib38) 2023 Pomara (10.1016/j.cbi.2023.110557_bib48) 2020; 144 Comoglu (10.1016/j.cbi.2023.110557_bib57) 2022; 9 Nazerian (10.1016/j.cbi.2023.110557_bib5) 2022; 113 Karasova (10.1016/j.cbi.2023.110557_bib25) 2017; 277 Sattar (10.1016/j.cbi.2023.110557_bib13) 2020; 142 Chen (10.1016/j.cbi.2023.110557_bib24) 2017; 114 Sharma (10.1016/j.cbi.2023.110557_bib36) 2023 Richard (10.1016/j.cbi.2023.110557_bib15) 2022; 21 Nakajima (10.1016/j.cbi.2023.110557_bib18) 2021; 82 Cox (10.1016/j.cbi.2023.110557_bib52) 2020; 287 Türker (10.1016/j.cbi.2023.110557_bib58) 2022; 15 Karakike (10.1016/j.cbi.2023.110557_bib6) 2021; 49 Zivkovic (10.1016/j.cbi.2023.110557_bib46) 2015; 2015 Buyukozkan (10.1016/j.cbi.2023.110557_bib14) 2022; 25 Asad (10.1016/j.cbi.2023.110557_bib50) 2020; 3 Abou-Hatab (10.1016/j.cbi.2023.110557_bib26) 2000; 31 Inácio Lunkes (10.1016/j.cbi.2023.110557_bib28) 2006; 72 Schmidt (10.1016/j.cbi.2023.110557_bib47) 2021; 47 Lampón (10.1016/j.cbi.2023.110557_bib32) 2012; 11 Espeter (10.1016/j.cbi.2023.110557_bib45) 2022; 12 El-sayed (10.1016/j.cbi.2023.110557_bib56) 2019; 9 Xin (10.1016/j.cbi.2023.110557_bib11) 2023; 30 Lagoumintzis (10.1016/j.cbi.2023.110557_bib51) 2021; 149 De Vriese (10.1016/j.cbi.2023.110557_bib22) 2004; 145 Sipahioglu (10.1016/j.cbi.2023.110557_bib42) 2022; 9 Bahloul (10.1016/j.cbi.2023.110557_bib43) 2021; 37 |
| References_xml | – volume: 259 start-page: 271 year: Nov. 2016 end-page: 275 ident: bib30 article-title: Physiological roles for butyrylcholinesterase: a BChE-ghrelin axis publication-title: Chem. Biol. Interact. contributor: fullname: Gao – volume: 72 start-page: 28 year: Apr. 2006 end-page: 32 ident: bib28 article-title: Serum cholinesterase activity in diabetes and associated pathologies publication-title: Diabetes Res. Clin. Pract. contributor: fullname: Gonçalves – volume: 15 start-page: 6301 year: 2022 end-page: 6307, Jul ident: bib58 article-title: Evaluation of the Charlson comorbidity index and laboratory parameters as independent early mortality predictors in covid 19 patients publication-title: Int. J. Graph Multimed. contributor: fullname: Türker – volume: 241 start-page: 1 year: Jul. 2015 end-page: 5 ident: bib29 article-title: ‘Associations between serum cholinesterase and incident hyper-LDL cholesterolemia, hypertriglyceridemia and hypo-HDL cholesterolemia as well as changes in lipid levels in a health screening population’ publication-title: Atherosclerosis contributor: fullname: Oda – volume: 49 start-page: 2042 year: Dec. 2021 end-page: 2057 ident: bib6 article-title: Coronavirus disease 2019 as cause of viral sepsis: a systematic review and meta-analysis publication-title: Crit. Care Med. contributor: fullname: Karakike – volume: 145 start-page: 4997 year: 2004 end-page: 5005, Nov ident: bib22 article-title: Ghrelin degradation by serum and tissue homogenates: identification of the cleavage sites publication-title: Endocrinology contributor: fullname: Delporte – volume: 37 start-page: 84 year: Nov. 2021 end-page: 93 ident: bib43 article-title: Clinical characteristics and outcomes of critically ill COVID-19 patients in Sfax, Tunisia publication-title: Antiviral Chem. Chemother. contributor: fullname: Bahloul – volume: 110 start-page: 627 year: 2002 end-page: 639 ident: bib21 article-title: Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine publication-title: Neuroscience contributor: fullname: Lockridge – volume: 2018 year: Apr. 2018 ident: bib31 article-title: A sustained reduction in serum cholinesterase enzyme activity predicts patient outcome following sepsis publication-title: Mediat. Inflamm. contributor: fullname: Zivkovic – volume: 12 year: Sep. 2022 ident: bib45 article-title: Critically ill COVID-19 patients show reduced point of care-measured butyrylcholinesterase activity—a prospective, monocentric observational study publication-title: Diagnostics contributor: fullname: Espeter – ident: bib2 – volume: 32 start-page: 44 year: 2020 end-page: 49 ident: bib33 article-title: Value of serum cholinesterase in the prognosis of septic shock publication-title: Zhonghua wei zhong bing ji jiu yi xue contributor: fullname: Zhao – volume: 47 start-page: 863 year: Jun. 2021 end-page: 872 ident: bib47 article-title: Point-of-care measured serum cholinesterase activity predicts patient outcome following severe burns publication-title: Burns contributor: fullname: Schmidt – year: 2023 ident: bib38 article-title: ‘Mechanical Ventilation’, in contributor: fullname: Giwa – volume: 9 start-page: 41 year: 2019 end-page: 46 ident: bib56 article-title: The crucial prognostic role of serum cholinesterase in detecting liver disease publication-title: Clin. Med. Diagn. contributor: fullname: ElBagoury – volume: 31 start-page: 193 year: Dec. 2000 end-page: 198 ident: bib26 article-title: Plasma esterase activities in young and old patients undergoing open inguinal hernia repair publication-title: Arch. Gerontol. Geriatr. contributor: fullname: Woodhouse – volume: 421 year: Jan. 2003 ident: bib49 article-title: Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation publication-title: Nature contributor: fullname: Wang – volume: 82 start-page: 282 year: Feb. 2021 end-page: 327 ident: bib41 article-title: Serum cholinesterase associated with COVID-19 pneumonia severity and mortality publication-title: J. Infect. contributor: fullname: Nakajima – volume: 599 start-page: 1057 year: 2021 end-page: 1065 ident: bib4 article-title: Silent hypoxaemia in COVID-19 patients publication-title: J. Physiol. contributor: fullname: Simonson – volume: 34 start-page: 26 year: Jan. 1990 end-page: 28 ident: bib27 article-title: Erythrocyte and plasma cholinesterase activity in normal pregnancy publication-title: Indian J. Physiol. Pharmacol. contributor: fullname: Joseph – volume: 1 start-page: 265 year: 2013 end-page: 268 ident: bib54 article-title: Assessment of the value of serum cholinesterase as a liver function test for cirrhotic patients publication-title: Biomed Rep contributor: fullname: Li – volume: 114 start-page: 10960 year: 2017 end-page: 10965 ident: bib24 article-title: Butyrylcholinesterase gene transfer in obese mice prevents postdieting body weight rebound by suppressing ghrelin signaling publication-title: Proc. Natl. Acad. Sci. U.S.A. contributor: fullname: Brimijoin – volume: 4 start-page: 31 year: 2013 end-page: 39 ident: bib55 article-title: Butyrylcholinesterase as a prognostic marker: a review of the literature publication-title: Journal of Cachexia, Sarcopenia and Muscle contributor: fullname: Pasanisi – volume: 30 year: Jan. 2023 ident: bib11 article-title: Hospitalizations and mortality during the first year of the COVID-19 pandemic in Hong Kong, China: an observational study publication-title: Lancet Reg Health West Pac contributor: fullname: Xin – volume: 25 year: Jul. 2022 ident: bib14 article-title: Integrative metabolomic and proteomic signatures define clinical outcomes in severe COVID-19 publication-title: iScience contributor: fullname: Buyukozkan – volume: 395 start-page: 497 year: Feb. 2020 end-page: 506 ident: bib1 article-title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China publication-title: Lancet contributor: fullname: Huang – volume: 462 start-page: 67 year: Oct. 2014 end-page: 75 ident: bib40 article-title: Optimal detection of cholinesterase activity in biological samples: modifications to the standard Ellman's assay publication-title: Anal. Biochem. contributor: fullname: Hrabovska – volume: 142 start-page: 4 year: Jul. 2020 end-page: 6 ident: bib13 article-title: Obesity is a risk factor for severe COVID-19 infection: multiple potential mechanisms publication-title: Circulation contributor: fullname: McMurray – volume: 32 start-page: 1445 year: 1994 end-page: 1457, Nov ident: bib20 article-title: Tissue distribution of human acetylcholinesterase and butyrylcholinesterase messenger RNA publication-title: Toxicon contributor: fullname: Lockridge – volume: 369 year: May 2020 ident: bib7 article-title: Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study publication-title: BMJ contributor: fullname: Docherty – volume: 21 year: Oct. 2022 ident: bib15 article-title: Early prediction of COVID-19 patient survival by targeted plasma multi-omics and machine learning publication-title: Mol. Cell. Proteomics contributor: fullname: Richard – volume: 24 start-page: 93 year: Jan. 1993 end-page: 99 ident: bib53 article-title: Factors affecting inter-individual variation in human plasma cholinesterase activity: body weight, height, sex, genetic polymorphism and age publication-title: Arch. Environ. Contam. Toxicol. contributor: fullname: Brock – volume: 3 start-page: e224 year: Mar. 2021 end-page: e233 ident: bib9 article-title: COVID-19 vasculitis and novel vasculitis mimics publication-title: Lancet Rheumatol contributor: fullname: Watad – volume: 13 year: 2022 ident: bib17 article-title: Laboratory biomarkers for diagnosis and prognosis in COVID-19 publication-title: Front. Immunol. contributor: fullname: Rocco – volume: 287 start-page: 120 year: 2020 end-page: 133 ident: bib52 article-title: Beyond neurotransmission: acetylcholine in immunity and inflammation publication-title: J. Intern. Med. contributor: fullname: Cox – year: Jan. 2022 ident: bib35 article-title: Public Health Authority of the Slovak Republic, ‘Occurrence of the omikron variant as of 21/01/2022: the number of confirmed cases has steadily increased to 282’ – volume: 58 start-page: 1055 year: 2012 end-page: 1058, Jun ident: bib34 article-title: Butyrylcholinesterase activity predicts long-term survival in patients with coronary artery disease publication-title: Clin. Chem. contributor: fullname: Goliasch – volume: 2015 year: Feb. 2015 ident: bib46 article-title: ‘Reduced serum butyrylcholinesterase activity indicates severe systemic inflammation in critically ill patients’ publication-title: Mediat. Inflamm. contributor: fullname: Hofer – volume: 9 start-page: 117 year: Apr. 2022 end-page: 121 ident: bib57 article-title: Does the Charlson comorbidity index help predict the risk of death in COVID-19 patients? publication-title: North Clin Istanb contributor: fullname: Kant – volume: 11 start-page: 356 year: May 2012 end-page: 363 ident: bib32 article-title: Association between butyrylcholinesterase activity and low-grade systemic inflammation publication-title: Ann. Hepatol. contributor: fullname: Tutor – volume: 96 start-page: 2528 year: Oct. 2021 end-page: 2539 ident: bib10 article-title: Factors associated with severe COVID-19 infection among persons of different ages living in a defined midwestern US population publication-title: Mayo Clin. Proc. contributor: fullname: Sauver – year: 2022 ident: bib37 article-title: ‘Noninvasive Ventilation’, in contributor: fullname: Sankari – volume: 40 start-page: 373 year: 1987 end-page: 383 ident: bib39 article-title: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation publication-title: J. Chron. Dis. contributor: fullname: MacKenzie – volume: 3 start-page: 51 year: Dec. 2020 end-page: 62 ident: bib50 article-title: The role of vagus nerve stimulation in sepsis publication-title: Bioelectronics in Medicine contributor: fullname: Stavrakis – volume: 277 start-page: 24 year: Aug. 2017 end-page: 31 ident: bib25 article-title: Activity of cholinesterases in a young and healthy middle-European population: relevance for toxicology, pharmacology and clinical praxis publication-title: Toxicol. Lett. contributor: fullname: Karasova – volume: 148 start-page: 34 year: Apr. 2015 end-page: 46 ident: bib19 article-title: Review of human butyrylcholinesterase structure, function, genetic variants, history of use in the clinic, and potential therapeutic uses publication-title: Pharmacol. Ther. contributor: fullname: Lockridge – volume: 144 year: Nov. 2020 ident: bib48 article-title: Impairment of the cholinergic anti-inflammatory pathway in older subjects with severe COVID-19 publication-title: Med. Hypotheses contributor: fullname: Imbimbo – volume: 27 year: Apr. 2023 ident: bib12 article-title: Severe COVID-19 outcomes by cardiovascular risk profile in England in 2020: a population-based cohort study publication-title: Lancet Reg Health Eur contributor: fullname: Warren-Gash – volume: 41 start-page: 1413 year: 2017 end-page: 1419, Sep ident: bib23 article-title: Butyrylcholinesterase regulates central ghrelin signaling and has an impact on food intake and glucose homeostasis publication-title: Int. J. Obes. contributor: fullname: Brimijoin – ident: bib3 article-title: ‘Statement on the fourteenth meeting of the International Health Regulations (2005) Emergency Committee regarding the coronavirus disease (COVID-19) pandemic’ – volume: 9 year: 2022 ident: bib42 article-title: Does serum butyrylcholinesterase level determine the severity and mortality of COVID-19 pneumonia?: prospective study publication-title: Front. Med. contributor: fullname: Sipahioglu – volume: 4 start-page: e632 year: Sep. 2022 end-page: e645 ident: bib16 article-title: Development of a multiomics model for identification of predictive biomarkers for COVID-19 severity: a retrospective cohort study publication-title: Lancet Digit Health contributor: fullname: Byeon – volume: 107 start-page: 534 year: Sep. 2022 end-page: 539 ident: bib44 article-title: Prognostic value of serum cholinesterase activity in severe SARS-CoV-2–infected patients requiring intensive care unit admission publication-title: Am. J. Trop. Med. Hyg. contributor: fullname: Bahloul – volume: 149 year: Mar. 2021 ident: bib51 article-title: Nicotinic cholinergic system and COVID-19: in silico identification of interactions between α7 nicotinic acetylcholine receptor and the cryptic epitopes of SARS-Co-V and SARS-CoV-2 Spike glycoproteins publication-title: Food Chem. Toxicol. contributor: fullname: Lagoumintzis – year: 2023 ident: bib36 article-title: High flow nasal cannula publication-title: StatPearls [Internet] contributor: fullname: Chakraborty – volume: 82 start-page: 282 year: Feb. 2021 end-page: 327 ident: bib18 article-title: Serum cholinesterase associated with COVID-19 pneumonia severity and mortality publication-title: J. Infect. contributor: fullname: Nakajima – volume: 22 start-page: 1142 year: 2022 end-page: 1152, Aug ident: bib8 article-title: Venous or arterial thrombosis and deaths among COVID-19 cases: a European network cohort study publication-title: Lancet Infect. Dis. contributor: fullname: Burn – volume: 113 year: Dec. 2022 ident: bib5 article-title: Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: molecular pathways and potential therapeutic options publication-title: Int. Immunopharm. contributor: fullname: Hashemi – volume: 35 start-page: 2801 year: 2020 end-page: 2803, Sep ident: bib59 article-title: Charlson comorbidity index score and risk of severe outcome and death in Danish COVID-19 patients publication-title: J. Gen. Intern. Med. contributor: fullname: Christensen – volume: 21 issue: 10 year: 2022 ident: 10.1016/j.cbi.2023.110557_bib15 article-title: Early prediction of COVID-19 patient survival by targeted plasma multi-omics and machine learning publication-title: Mol. Cell. Proteomics doi: 10.1016/j.mcpro.2022.100277 contributor: fullname: Richard – volume: 148 start-page: 34 year: 2015 ident: 10.1016/j.cbi.2023.110557_bib19 article-title: Review of human butyrylcholinesterase structure, function, genetic variants, history of use in the clinic, and potential therapeutic uses publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2014.11.011 contributor: fullname: Lockridge – volume: 32 start-page: 1445 issue: 11 year: 1994 ident: 10.1016/j.cbi.2023.110557_bib20 article-title: Tissue distribution of human acetylcholinesterase and butyrylcholinesterase messenger RNA publication-title: Toxicon doi: 10.1016/0041-0101(94)90416-2 contributor: fullname: Jbilo – volume: 22 start-page: 1142 issue: 8 year: 2022 ident: 10.1016/j.cbi.2023.110557_bib8 article-title: Venous or arterial thrombosis and deaths among COVID-19 cases: a European network cohort study publication-title: Lancet Infect. Dis. doi: 10.1016/S1473-3099(22)00223-7 contributor: fullname: Burn – volume: 287 start-page: 120 issue: 2 year: 2020 ident: 10.1016/j.cbi.2023.110557_bib52 article-title: Beyond neurotransmission: acetylcholine in immunity and inflammation publication-title: J. Intern. Med. doi: 10.1111/joim.13006 contributor: fullname: Cox – volume: 3 start-page: e224 issue: 3 year: 2021 ident: 10.1016/j.cbi.2023.110557_bib9 article-title: COVID-19 vasculitis and novel vasculitis mimics publication-title: Lancet Rheumatol doi: 10.1016/S2665-9913(20)30420-3 contributor: fullname: McGonagle – volume: 72 start-page: 28 issue: 1 year: 2006 ident: 10.1016/j.cbi.2023.110557_bib28 article-title: Serum cholinesterase activity in diabetes and associated pathologies publication-title: Diabetes Res. Clin. Pract. doi: 10.1016/j.diabres.2005.08.009 contributor: fullname: Inácio Lunkes – volume: 145 start-page: 4997 issue: 11 year: 2004 ident: 10.1016/j.cbi.2023.110557_bib22 article-title: Ghrelin degradation by serum and tissue homogenates: identification of the cleavage sites publication-title: Endocrinology doi: 10.1210/en.2004-0569 contributor: fullname: De Vriese – volume: 1 start-page: 265 issue: 2 year: 2013 ident: 10.1016/j.cbi.2023.110557_bib54 article-title: Assessment of the value of serum cholinesterase as a liver function test for cirrhotic patients publication-title: Biomed Rep doi: 10.3892/br.2013.60 contributor: fullname: Meng – volume: 15 start-page: 6301 year: 2022 ident: 10.1016/j.cbi.2023.110557_bib58 article-title: Evaluation of the Charlson comorbidity index and laboratory parameters as independent early mortality predictors in covid 19 patients publication-title: Int. J. Graph Multimed. contributor: fullname: Türker – volume: 30 year: 2023 ident: 10.1016/j.cbi.2023.110557_bib11 article-title: Hospitalizations and mortality during the first year of the COVID-19 pandemic in Hong Kong, China: an observational study publication-title: Lancet Reg Health West Pac contributor: fullname: Xin – volume: 142 start-page: 4 issue: 1 year: 2020 ident: 10.1016/j.cbi.2023.110557_bib13 article-title: Obesity is a risk factor for severe COVID-19 infection: multiple potential mechanisms publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.120.047659 contributor: fullname: Sattar – volume: 25 issue: 7 year: 2022 ident: 10.1016/j.cbi.2023.110557_bib14 article-title: Integrative metabolomic and proteomic signatures define clinical outcomes in severe COVID-19 publication-title: iScience doi: 10.1016/j.isci.2022.104612 contributor: fullname: Buyukozkan – volume: 144 year: 2020 ident: 10.1016/j.cbi.2023.110557_bib48 article-title: Impairment of the cholinergic anti-inflammatory pathway in older subjects with severe COVID-19 publication-title: Med. Hypotheses doi: 10.1016/j.mehy.2020.110274 contributor: fullname: Pomara – volume: 31 start-page: 193 issue: 3 year: 2000 ident: 10.1016/j.cbi.2023.110557_bib26 article-title: Plasma esterase activities in young and old patients undergoing open inguinal hernia repair publication-title: Arch. Gerontol. Geriatr. doi: 10.1016/S0167-4943(00)00073-X contributor: fullname: Abou-Hatab – volume: 32 start-page: 44 issue: 1 year: 2020 ident: 10.1016/j.cbi.2023.110557_bib33 article-title: Value of serum cholinesterase in the prognosis of septic shock publication-title: Zhonghua wei zhong bing ji jiu yi xue contributor: fullname: Zhao – year: 2022 ident: 10.1016/j.cbi.2023.110557_bib37 contributor: fullname: Gong – volume: 395 start-page: 497 issue: 10223 year: 2020 ident: 10.1016/j.cbi.2023.110557_bib1 article-title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China publication-title: Lancet doi: 10.1016/S0140-6736(20)30183-5 contributor: fullname: Huang – volume: 113 year: 2022 ident: 10.1016/j.cbi.2023.110557_bib5 article-title: Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: molecular pathways and potential therapeutic options publication-title: Int. Immunopharm. doi: 10.1016/j.intimp.2022.109428 contributor: fullname: Nazerian – volume: 96 start-page: 2528 issue: 10 year: 2021 ident: 10.1016/j.cbi.2023.110557_bib10 article-title: Factors associated with severe COVID-19 infection among persons of different ages living in a defined midwestern US population publication-title: Mayo Clin. Proc. doi: 10.1016/j.mayocp.2021.06.023 contributor: fullname: Sauver – volume: 11 start-page: 356 issue: 3 year: 2012 ident: 10.1016/j.cbi.2023.110557_bib32 article-title: Association between butyrylcholinesterase activity and low-grade systemic inflammation publication-title: Ann. Hepatol. doi: 10.1016/S1665-2681(19)30932-9 contributor: fullname: Lampón – volume: 47 start-page: 863 issue: 4 year: 2021 ident: 10.1016/j.cbi.2023.110557_bib47 article-title: Point-of-care measured serum cholinesterase activity predicts patient outcome following severe burns publication-title: Burns doi: 10.1016/j.burns.2020.10.027 contributor: fullname: Schmidt – volume: 58 start-page: 1055 issue: 6 year: 2012 ident: 10.1016/j.cbi.2023.110557_bib34 article-title: Butyrylcholinesterase activity predicts long-term survival in patients with coronary artery disease publication-title: Clin. Chem. doi: 10.1373/clinchem.2011.175984 contributor: fullname: Goliasch – volume: 9 year: 2022 ident: 10.1016/j.cbi.2023.110557_bib42 article-title: Does serum butyrylcholinesterase level determine the severity and mortality of COVID-19 pneumonia?: prospective study publication-title: Front. Med. doi: 10.3389/fmed.2022.940533 contributor: fullname: Sipahioglu – volume: 4 start-page: 31 issue: 1 year: 2013 ident: 10.1016/j.cbi.2023.110557_bib55 article-title: Butyrylcholinesterase as a prognostic marker: a review of the literature publication-title: Journal of Cachexia, Sarcopenia and Muscle doi: 10.1007/s13539-012-0083-5 contributor: fullname: Santarpia – volume: 149 year: 2021 ident: 10.1016/j.cbi.2023.110557_bib51 article-title: Nicotinic cholinergic system and COVID-19: in silico identification of interactions between α7 nicotinic acetylcholine receptor and the cryptic epitopes of SARS-Co-V and SARS-CoV-2 Spike glycoproteins publication-title: Food Chem. Toxicol. doi: 10.1016/j.fct.2021.112009 contributor: fullname: Lagoumintzis – volume: 107 start-page: 534 issue: 3 year: 2022 ident: 10.1016/j.cbi.2023.110557_bib44 article-title: Prognostic value of serum cholinesterase activity in severe SARS-CoV-2–infected patients requiring intensive care unit admission publication-title: Am. J. Trop. Med. Hyg. doi: 10.4269/ajtmh.21-0934 contributor: fullname: Bahloul – volume: 49 start-page: 2042 issue: 12 year: 2021 ident: 10.1016/j.cbi.2023.110557_bib6 article-title: Coronavirus disease 2019 as cause of viral sepsis: a systematic review and meta-analysis publication-title: Crit. Care Med. doi: 10.1097/CCM.0000000000005195 contributor: fullname: Karakike – volume: 114 start-page: 10960 issue: 41 year: 2017 ident: 10.1016/j.cbi.2023.110557_bib24 article-title: Butyrylcholinesterase gene transfer in obese mice prevents postdieting body weight rebound by suppressing ghrelin signaling publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.1706517114 contributor: fullname: Chen – volume: 34 start-page: 26 issue: 1 year: 1990 ident: 10.1016/j.cbi.2023.110557_bib27 article-title: Erythrocyte and plasma cholinesterase activity in normal pregnancy publication-title: Indian J. Physiol. Pharmacol. contributor: fullname: Venkataraman – volume: 37 start-page: 84 issue: 1 year: 2021 ident: 10.1016/j.cbi.2023.110557_bib43 article-title: Clinical characteristics and outcomes of critically ill COVID-19 patients in Sfax, Tunisia publication-title: Antiviral Chem. Chemother. contributor: fullname: Bahloul – volume: 599 start-page: 1057 issue: 4 year: 2021 ident: 10.1016/j.cbi.2023.110557_bib4 article-title: Silent hypoxaemia in COVID-19 patients publication-title: J. Physiol. doi: 10.1113/JP280769 contributor: fullname: Simonson – volume: 82 start-page: 282 issue: 2 year: 2021 ident: 10.1016/j.cbi.2023.110557_bib41 article-title: Serum cholinesterase associated with COVID-19 pneumonia severity and mortality publication-title: J. Infect. doi: 10.1016/j.jinf.2020.08.021 contributor: fullname: Nakajima – volume: 9 start-page: 117 issue: 2 year: 2022 ident: 10.1016/j.cbi.2023.110557_bib57 article-title: Does the Charlson comorbidity index help predict the risk of death in COVID-19 patients? publication-title: North Clin Istanb contributor: fullname: Comoglu – volume: 241 start-page: 1 issue: 1 year: 2015 ident: 10.1016/j.cbi.2023.110557_bib29 article-title: ‘Associations between serum cholinesterase and incident hyper-LDL cholesterolemia, hypertriglyceridemia and hypo-HDL cholesterolemia as well as changes in lipid levels in a health screening population’ publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2015.04.804 contributor: fullname: Oda – volume: 24 start-page: 93 issue: 1 year: 1993 ident: 10.1016/j.cbi.2023.110557_bib53 article-title: Factors affecting inter-individual variation in human plasma cholinesterase activity: body weight, height, sex, genetic polymorphism and age publication-title: Arch. Environ. Contam. Toxicol. doi: 10.1007/BF01061095 contributor: fullname: Brock – volume: 421 issue: 6921 year: 2003 ident: 10.1016/j.cbi.2023.110557_bib49 article-title: Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation publication-title: Nature doi: 10.1038/nature01339 contributor: fullname: Wang – volume: 13 year: 2022 ident: 10.1016/j.cbi.2023.110557_bib17 article-title: Laboratory biomarkers for diagnosis and prognosis in COVID-19 publication-title: Front. Immunol. doi: 10.3389/fimmu.2022.857573 contributor: fullname: Battaglini – volume: 41 start-page: 1413 issue: 9 year: 2017 ident: 10.1016/j.cbi.2023.110557_bib23 article-title: Butyrylcholinesterase regulates central ghrelin signaling and has an impact on food intake and glucose homeostasis publication-title: Int. J. Obes. doi: 10.1038/ijo.2017.123 contributor: fullname: Chen – volume: 40 start-page: 373 issue: 5 year: 1987 ident: 10.1016/j.cbi.2023.110557_bib39 article-title: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation publication-title: J. Chron. Dis. doi: 10.1016/0021-9681(87)90171-8 contributor: fullname: Charlson – volume: 3 start-page: 51 issue: 4 year: 2020 ident: 10.1016/j.cbi.2023.110557_bib50 article-title: The role of vagus nerve stimulation in sepsis publication-title: Bioelectronics in Medicine doi: 10.2217/bem-2020-0010 contributor: fullname: Asad – volume: 9 start-page: 41 issue: 3 year: 2019 ident: 10.1016/j.cbi.2023.110557_bib56 article-title: The crucial prognostic role of serum cholinesterase in detecting liver disease publication-title: Clin. Med. Diagn. contributor: fullname: El-sayed – volume: 2018 year: 2018 ident: 10.1016/j.cbi.2023.110557_bib31 article-title: A sustained reduction in serum cholinesterase enzyme activity predicts patient outcome following sepsis publication-title: Mediat. Inflamm. doi: 10.1155/2018/1942193 contributor: fullname: Zivkovic – volume: 12 issue: 9 year: 2022 ident: 10.1016/j.cbi.2023.110557_bib45 article-title: Critically ill COVID-19 patients show reduced point of care-measured butyrylcholinesterase activity—a prospective, monocentric observational study publication-title: Diagnostics doi: 10.3390/diagnostics12092150 contributor: fullname: Espeter – volume: 2015 year: 2015 ident: 10.1016/j.cbi.2023.110557_bib46 article-title: ‘Reduced serum butyrylcholinesterase activity indicates severe systemic inflammation in critically ill patients’ publication-title: Mediat. Inflamm. doi: 10.1155/2015/274607 contributor: fullname: Zivkovic – volume: 4 start-page: e632 issue: 9 year: 2022 ident: 10.1016/j.cbi.2023.110557_bib16 article-title: Development of a multiomics model for identification of predictive biomarkers for COVID-19 severity: a retrospective cohort study publication-title: Lancet Digit Health doi: 10.1016/S2589-7500(22)00112-1 contributor: fullname: Byeon – volume: 27 year: 2023 ident: 10.1016/j.cbi.2023.110557_bib12 article-title: Severe COVID-19 outcomes by cardiovascular risk profile in England in 2020: a population-based cohort study publication-title: Lancet Reg Health Eur contributor: fullname: Warren-Gash – year: 2023 ident: 10.1016/j.cbi.2023.110557_bib36 article-title: High flow nasal cannula contributor: fullname: Sharma – volume: 277 start-page: 24 year: 2017 ident: 10.1016/j.cbi.2023.110557_bib25 article-title: Activity of cholinesterases in a young and healthy middle-European population: relevance for toxicology, pharmacology and clinical praxis publication-title: Toxicol. Lett. doi: 10.1016/j.toxlet.2017.04.017 contributor: fullname: Karasova – volume: 462 start-page: 67 year: 2014 ident: 10.1016/j.cbi.2023.110557_bib40 article-title: Optimal detection of cholinesterase activity in biological samples: modifications to the standard Ellman's assay publication-title: Anal. Biochem. doi: 10.1016/j.ab.2014.05.031 contributor: fullname: Dingova – volume: 369 year: 2020 ident: 10.1016/j.cbi.2023.110557_bib7 article-title: Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study publication-title: BMJ contributor: fullname: Docherty – volume: 82 start-page: 282 issue: 2 year: 2021 ident: 10.1016/j.cbi.2023.110557_bib18 article-title: Serum cholinesterase associated with COVID-19 pneumonia severity and mortality publication-title: J. Infect. doi: 10.1016/j.jinf.2020.08.021 contributor: fullname: Nakajima – volume: 259 start-page: 271 year: 2016 ident: 10.1016/j.cbi.2023.110557_bib30 article-title: Physiological roles for butyrylcholinesterase: a BChE-ghrelin axis publication-title: Chem. Biol. Interact. doi: 10.1016/j.cbi.2016.02.013 contributor: fullname: Brimijoin – volume: 110 start-page: 627 issue: 4 year: 2002 ident: 10.1016/j.cbi.2023.110557_bib21 article-title: Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine publication-title: Neuroscience doi: 10.1016/S0306-4522(01)00613-3 contributor: fullname: Mesulam – volume: 35 start-page: 2801 issue: 9 year: 2020 ident: 10.1016/j.cbi.2023.110557_bib59 article-title: Charlson comorbidity index score and risk of severe outcome and death in Danish COVID-19 patients publication-title: J. Gen. Intern. Med. doi: 10.1007/s11606-020-05991-z contributor: fullname: Christensen – year: 2023 ident: 10.1016/j.cbi.2023.110557_bib38 contributor: fullname: Hickey |
| SSID | ssj0000240 |
| Score | 2.453427 |
| Snippet | The COVID-19 pandemic represents an excessive burden on health care systems worldwide and the number of patients who require special care in the clinical... |
| SourceID | proquest crossref pubmed elsevier |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 110557 |
| SubjectTerms | Biomarker Butyrylcholinesterase C-reactive protein COVID-19 Interleukin-6 SARS-CoV-2 |
| Title | Serum butyrylcholinesterase as a marker of COVID-19 mortality: Results of the monocentric prospective observational study |
| URI | https://dx.doi.org/10.1016/j.cbi.2023.110557 https://www.ncbi.nlm.nih.gov/pubmed/37209860 https://search.proquest.com/docview/2816761692 |
| Volume | 381 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELaqIgQXVFqgS6EyEuKAlDZ2YifDbVmotiCKhCjqzYoTR1rUTapNctgLv50ZJy5CAg5cosRO5JFnMg_7Gw9jLyVoKSr03FSudZRmMUR5IpIoK7KkqHKoE0X5zp8u9PIy_XClrnbYIuTCEKxy0v2jTvfaemo5nWbz9Ga1ohzfGGRGVbO8IaKM8hTNH8r0yY9fMA86wytUU6O3w86mx3iVdnVC9cMJDK_IQv3ZNv3N9_Q26GyPPZicRz4f6XvIdlyzzw7mDQbO6y1_xT2c06-T77O7b8PdvUUo6nbAtqgbhjW3Q7_dbK9J9RHsnbKQO8eLjhd8TXidDW9rvvj87fxdJICvvYuO7vob_sV1w3XfUTd6jtjTtB7euSo5Uh_SNnlrbxd7kV5_hO0jdnn2_utiGU3VF6IyAd1HFkOvWsaqEGBRO7saLGAbxDaRLi1TkdagoNCyrHKUhEQKB7KGAn9rvKoyecx2m7Zxh4zbVNeq0jYWFUZfaQm5LSF2TlsMbmoQM_Y6zLu5GQ_ZMAF99t0gkwwxyYxMmrE0cMb8JikGjcC_PnsRuGhwzmlbpGhcO3RG5kJnWmiQM_ZkZO8tFVTDB3IdP_2_QY_YfXqiNWipnrHdfjO45-jE9PbYS-kxuzM__7i8-AkW0vAA |
| link.rule.ids | 315,783,787,4509,24128,27936,27937,45597,45691 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3BbtQwELVKEWovqLRQtlAwEuKAlDZ2EifDrV2ottAWCbWoNytOHGlRN6k2yWEvfDszTlyEVDhwiSI7UUYeZ-aN_cbD2FsJSooSkVuSKRXEaQhBFokoSPM0yssMqiihfOfzCzW7ij9fJ9drbOpzYYhWOdr-waY7az22HI6jeXg7n1OObwgypapZzhGlD9jDmPAxTuqDn795HnSIly-nRo_7rU1H8irM_IAKiBMbPiEXdb9z-hv4dE7oZIs9HtEjPxoEfMLWbL3Ndo5qjJwXK_6OOz6nWyjfZo-O_d3G1Fd122ErNA79gpu-Wy1XN2T7iPdOacit5XnLc74gws6SNxWffv1--jEQwBcOoyNe_8C_2ba_6VrqRuiIPXXj-J3zgqP0Pm-TN-ZutRfldWfYPmVXJ58up7NgLL8QFBGoLjAYe1UyTHIBBs2zrcAAtkFoImnjIhZxBQnkShZlhlMhksKCrCDH_xqvSRE9Y-t1U9vnjJtYVUmpTChKDL_iAjJTQGitMhjdVCAm7L0fd307nLKhPf3sh0YlaVKSHpQ0YbHXjP5jqmj0Av967Y3XosYxp32RvLZN32qZCZUqoUBO2O6g3jspqIgPZCrc-7-PvmYbs8vzM312evHlBdukHlqQlslLtt4te7uPiKYzr9yM_QW1MvGZ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Serum+butyrylcholinesterase+as+a+marker+of+COVID-19+mortality%3A+Results+of+the+monocentric+prospective+observational+study&rft.jtitle=Chemico-biological+interactions&rft.au=Markuskova%2C+Lucia&rft.au=Javorova+Rihova%2C+Zuzana&rft.au=Fazekas%2C+Tomas&rft.au=Martinkovicova%2C+Anna&rft.date=2023-08-25&rft.eissn=1872-7786&rft.volume=381&rft.spage=110557&rft.epage=110557&rft_id=info:doi/10.1016%2Fj.cbi.2023.110557&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0009-2797&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0009-2797&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0009-2797&client=summon |