Long-term sevoflurane exposure resulted in temporary rather than lasting cognitive impairment in Drosophila

• Published in: Behavioural brain research Vol. 442; p. 114327
• Main Authors: Liu, Ziming, Pan, Xuanyi, Guo, Jiguang, Li, Liping, Tang, Yuxin, Wu, Guangyi, Li, Ming, Wang, Hongjie
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 28.03.2023
• Subjects: Adenosine Triphosphate; Anesthesia; Anesthetics, Inhalation - toxicity; Animals; Cognitive Dysfunction - chemically induced; Cognitive impairment; Drosophila; Drosophila melanogaster - drug effects; Neuroapoptosis; Reactive Oxygen Species; Sevoflurane - toxicity; Anesthesia; Reactive oxygen species; Drosophila; Neuroapoptosis; Cognitive impairment

Sevoflurane is the primary inhaled anesthetic used in pediatric surgery. It has been the focus of research since animal models studies found that it was neurotoxic to the developing brain two decades ago. However, whether pediatric general anesthesia can lead to permanent cognitive deficits remained...