Early pancreas transplant outcomes with histidine-tryptophan-ketoglutarate preservation: a multicenter study
Little is known about the use of histidine-tryptophan-ketoglutarate (HTK) preservation solution for pancreas preservation. We compared early pancreas graft outcomes at four pancreas transplant programs within the state of Michigan in 2002 and 2003 (University of Wisconsin [UW] era) with those in 200...
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Published in | Transplantation Vol. 82; no. 1; p. 136 |
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Main Authors | , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
15.07.2006
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Abstract | Little is known about the use of histidine-tryptophan-ketoglutarate (HTK) preservation solution for pancreas preservation. We compared early pancreas graft outcomes at four pancreas transplant programs within the state of Michigan in 2002 and 2003 (University of Wisconsin [UW] era) with those in 2004 (HTK era). The primary endpoint was early graft loss. The UW group (n=41) and the HTK group (n=36) had similar outcomes with respect to: technical graft loss (9.8% vs. 8.3%, P=NS), 90-day graft function (90.2% vs. 86.1%, P=NS), and rate of pancreatic leak/abscess (12.2% vs. 11.1%, P=NS). There were also no significant differences in postoperative amylase and lipase levels between the two groups. The HTK group did have significantly more acute rejection within the first 180 days (25.0% vs. 9.8%, P<0.05). HTK is a suitable substitute for UW in the preservation of pancreas allografts. |
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AbstractList | Little is known about the use of histidine-tryptophan-ketoglutarate (HTK) preservation solution for pancreas preservation. We compared early pancreas graft outcomes at four pancreas transplant programs within the state of Michigan in 2002 and 2003 (University of Wisconsin [UW] era) with those in 2004 (HTK era). The primary endpoint was early graft loss. The UW group (n=41) and the HTK group (n=36) had similar outcomes with respect to: technical graft loss (9.8% vs. 8.3%, P=NS), 90-day graft function (90.2% vs. 86.1%, P=NS), and rate of pancreatic leak/abscess (12.2% vs. 11.1%, P=NS). There were also no significant differences in postoperative amylase and lipase levels between the two groups. The HTK group did have significantly more acute rejection within the first 180 days (25.0% vs. 9.8%, P<0.05). HTK is a suitable substitute for UW in the preservation of pancreas allografts. |
Author | Moyer, Alice Oh, Henry Yoshida, Atsushi Gruber, Scott A Arenas, Juan D Kim, Dean Y Magee, John C Granger, Darla K Pelletier, Shawn J Punch, Jeffrey D Englesbe, Michael J Pietroski, Richard Campbell, Jr, Darrell A Sung, Randall S |
Author_xml | – sequence: 1 givenname: Michael J surname: Englesbe fullname: Englesbe, Michael J organization: Division of Transplantation, Department of Surgery, University of Michigan Health System, Ann Arbor, MI 48109-0331, USA – sequence: 2 givenname: Alice surname: Moyer fullname: Moyer, Alice – sequence: 3 givenname: Dean Y surname: Kim fullname: Kim, Dean Y – sequence: 4 givenname: Darla K surname: Granger fullname: Granger, Darla K – sequence: 5 givenname: Richard surname: Pietroski fullname: Pietroski, Richard – sequence: 6 givenname: Atsushi surname: Yoshida fullname: Yoshida, Atsushi – sequence: 7 givenname: Juan D surname: Arenas fullname: Arenas, Juan D – sequence: 8 givenname: Henry surname: Oh fullname: Oh, Henry – sequence: 9 givenname: Shawn J surname: Pelletier fullname: Pelletier, Shawn J – sequence: 10 givenname: Darrell A surname: Campbell, Jr fullname: Campbell, Jr, Darrell A – sequence: 11 givenname: Jeffrey D surname: Punch fullname: Punch, Jeffrey D – sequence: 12 givenname: John C surname: Magee fullname: Magee, John C – sequence: 13 givenname: Scott A surname: Gruber fullname: Gruber, Scott A – sequence: 14 givenname: Randall S surname: Sung fullname: Sung, Randall S |
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SubjectTerms | Adult Female Glucose - pharmacology Graft Rejection Graft Survival Humans Male Mannitol - pharmacology Organ Preservation Solutions - pharmacology Pancreas - drug effects Pancreas Transplantation Potassium Chloride - pharmacology Procaine - pharmacology |
Title | Early pancreas transplant outcomes with histidine-tryptophan-ketoglutarate preservation: a multicenter study |
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