A Single Light-Responsive Sizer Can Control Multiple-Fission Cycles in Chlamydomonas

• Published in: Current biology Vol. 30; no. 4; pp. 634 - 644.e7
• Main Authors: Heldt, Frank S., Tyson, John J., Cross, Frederick R., Novák, Béla
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 24.02.2020
• Subjects: bistability; cell cycle; Cell Cycle - radiation effects; cell size control; Chlamydomonas reinhardtii; Chlamydomonas reinhardtii - growth & development; Chlamydomonas reinhardtii - physiology; Chlamydomonas reinhardtii - radiation effects; Light; mathematical model; multiple fission; systems biology; systems biology; bistability; cell cycle; Chlamydomonas reinhardtii; multiple fission; mathematical model; cell size control

Most eukaryotic cells execute binary division after each mass doubling in order to maintain size homeostasis by coordinating cell growth and division. By contrast, the photosynthetic green alga Chlamydomonas can grow more than 8-fold during daytime and then, at night, undergo rapid cycles of DNA rep...