Developing Brain Glucose Transporters, Serotonin, Serotonin Transporter, and Oxytocin Receptor Expression in Response to Early-Life Hypocaloric and Hypercaloric Dietary, and Air Pollutant Exposures

• Published in: Developmental neuroscience Vol. 43; no. 1; pp. 27 - 42
• Main Authors: Ye, Xin, Shin, Bo-Chul, Baldauf, Claire, Ganguly, Amit, Ghosh, Shubhamoy, Devaskar, Sherin U.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland 01.01.2021
• Subjects: Air Pollutants; Animals; Brain; Diet; Female; Glucose Transport Proteins, Facilitative; Glucose Transporter Type 1; Glucose Transporter Type 3; Male; Mice; Oxytocin; Pregnancy; Receptors, Oxytocin; Research Article; Serotonin; Serotonin Plasma Membrane Transport Proteins; Neurodevelopment; Environmental exposure; Intrauterine growth restriction; Neurotransmitters; Fetal brain

Perturbed maternal diet and prenatal exposure to air pollution (AP) affect the fetal brain, predisposing to postnatal neurobehavioral disorders. Glucose transporters (GLUTs) are key in fueling neurotransmission; deficiency of the neuronal isoform GLUT3 culminates in autism spectrum disorders. Along...