The N-terminal Proline Hinge Motif Controls the Structure of Bovine Herpesvirus 1-encoded Inhibitor of the Transporter Associated with Antigen Processing Required for its Immunomodulatory Function
[Display omitted] •UL49.5 of BoHV-1 inhibits TAP transporter by mechanisms undetermined on a molecular level.•Mutations in 52PPQ54 proline hinge resulted in impaired TAP binding and inhibition.•According to MD, PPQ membrane anchor is key for UL49.5 structure and dynamical behavior.•52PPQ54 is requir...
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Published in | Journal of molecular biology Vol. 435; no. 5; p. 167964 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Ltd
01.03.2023
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Subjects | |
Online Access | Get full text |
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