Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer

• Published in: Oncotarget Vol. 6; no. 40; pp. 42632 - 42650
• Main Authors: Orlando, Ulises D, Castillo, Ana F, Dattilo, Melina A, Solano, Angela R, Maloberti, Paula M, Podesta, Ernesto J
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 15.12.2015
• Subjects: Animals; Blotting, Western; Breast Neoplasms - metabolism; Cell Line, Tumor; Coenzyme A Ligases - metabolism; Drug Resistance, Neoplasm - physiology; Female; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Mice; Mice, Nude; Receptors, Estrogen - metabolism; Research Paper; Signal Transduction - physiology; TOR Serine-Threonine Kinases - metabolism; Transfection; arachidonic acid; cancer; gene expression; tamoxifen; cell signaling

Although the role of acyl-CoA synthetase 4 (ACSL4) in mediating an aggressive phenotype is well accepted, there is little evidence as to the early steps through which ACSL4 increases tumor growth and progression. In this study, and by means of the stable transfection of MCF-7 cells with ACSL4 using...