Glycosylated piericidins from an endophytic streptomyces with cytotoxicity and antimicrobial activity

• Published in: Journal of antibiotics Vol. 71; no. 7; pp. 672 - 676
• Main Authors: Shang, Ning-Ning, Zhang, Zhouxin, Huang, Jian-Ping, Wang, Li, Luo, Jianying, Yang, Jing, Peng, Teng, Yan, Yijun, Ma, Ya-Tuan, Huang, Sheng-Xiong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2018; Springer Nature; Nature Publishing Group
• Subjects: 631/326/22/1290; 639/638/309/2144; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antibiotics, Antineoplastic - isolation & purification; Antibiotics, Antineoplastic - pharmacology; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Antimicrobial agents; Bacteriology; Biomedical and Life Sciences; Bioorganic Chemistry; Biotechnology & Applied Microbiology; Brief Communication; Cell Line, Tumor; Cytotoxicity; Endophytes - chemistry; Fermentation; Humans; Immunology; Life Sciences; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Medicinal Chemistry; Microbial Sensitivity Tests; Microbiology; Organic Chemistry; Penicillium - drug effects; Pharmacology & Pharmacy; Science & Technology; Streptomyces - chemistry; Xanthomonas - drug effects; ANTIBIOTICS

Two new glycosylated piericidins, glucopiericidinol A 3 ( 1 ) and 7-demethyl-glucopiericidin A ( 2 ), along with four known analogs were isolated from the culture broth of Streptomyces sp. KIB-H1083. The chemical structures of new compounds were elucidated by spectroscopic analyses. Their cytotoxici...