Prognostic model of lung adenocarcinoma constructed by the CENPA complex genes is closely related to immune infiltration

• Published in: Pathology, research and practice Vol. 228; p. 153680
• Main Authors: Zhou, Haomiao, Bian, Tingting, Qian, Li, Zhao, Cui, Zhang, Weiju, Zheng, Miaosen, Zhou, Hao, Liu, Lei, Sun, Hui, Li, Xiaoli, Zhang, Jianguo, Liu, Yifei
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.12.2021
• Subjects: Adenocarcinoma of Lung - genetics; Adenocarcinoma of Lung - immunology; Adult; Aged; Animals; Biomarkers, Tumor; CENPA-NAC complex; CENPA/H/M/N/U; Centromere Protein A - genetics; Chromosomal Proteins, Non-Histone - genetics; DdPCR; Gene Regulatory Networks; Histones - genetics; Humans; Immune infiltration; Lung adenocarcinoma; Lung Neoplasms - genetics; Lung Neoplasms - immunology; Male; Middle Aged; Nucleosomes; Prognosis; Prognostic model; Rabbits; Tumor Microenvironment - immunology; CENPA-NAC complex; Prognostic model; DdPCR; Lung adenocarcinoma; CENPA/H/M/N/U; Immune infiltration

Lung adenocarcinoma (LUAD) is still one of the primary malignant diseases leading to higher mortality worldwide. It has been previously reported that multiple genes in the CENPA-nucleosome associated complex (NAC) complex in lung cancer can be used as prognostic markers; however, there is lack of co...