Transposition: A CRISPR Way to Get Around

CRISPR-Cas systems provide sequence-specific immunity against selfish genetic elements in prokaryotes. Now, two studies show that transposon-encoded variants can guide sequence-specific transposition. These findings have important practical implications but also raise questions of why and how this s...

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Bibliographic Details
Published inCurrent biology Vol. 29; no. 18; pp. R886 - R889
Main Authors Dimitriu, Tatiana, Ashby, Ben, Westra, Edze R.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 23.09.2019
Subjects
Clustered Regularly Interspaced Short Palindromic Repeats
CRISPR-Cas Systems
DNA Transposable Elements
RNA
Transposases
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Summary:CRISPR-Cas systems provide sequence-specific immunity against selfish genetic elements in prokaryotes. Now, two studies show that transposon-encoded variants can guide sequence-specific transposition. These findings have important practical implications but also raise questions of why and how this strategy would benefit transposons. CRISPR-Cas systems provide sequence-specific immunity against selfish genetic elements in prokaryotes. Now, two studies show that transposon-encoded variants can guide sequence-specific transposition. These findings have important practical implications but also raise questions of why and how this strategy would benefit transposons.
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ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2019.08.010