Evaluation of the 52-week chronic toxicity of a novel phthalate-free plasticizer, Eco-DEHCH (bis(2-ethylhexyl) cyclohexane-1,4-dicarboxylate), in Han Wistar rats

• Published in: Food and chemical toxicology Vol. 176; p. 113809
• Main Authors: Lee, Ji-Young, Han, Hyo-Jeong, Ko, Soo Min, Jeong, Da Som, Kang, Jiyeon, Lee, Dong Hyun, Cha, Hwa Jun, Son, Woo-Chan
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2023
• Subjects: Alternative plasticizer; Animals; Bis(2-ethylhexyl) cyclohexane-1,4-dicarboxylate; Carboxylic Acids; Cyclohexanes; Diethylhexyl Phthalate - toxicity; Drug-Related Side Effects and Adverse Reactions; Eco-DEHCH; Esters - chemistry; Female; Humans; Male; Phthalate-free plasticizer; Phthalic Acids - toxicity; Plasticizers - toxicity; Rats; Rats, Wistar; Alternative plasticizer; Eco-DEHCH; Phthalate-free plasticizer; Bis(2-ethylhexyl) cyclohexane-1,4-dicarboxylate

Phthalate esters (PEs) are the most widely used class of plasticizers. Several PEs, however, were found to have adverse effects on the health of animals. A new phthalate-free plasticizer, Eco-DEHCH (bis(2-ethylhexyl) cyclohexane-1,4-dicarboxylate), was recently developed as an ecofriendly replacemen...