A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology

• Published in: Food and chemical toxicology Vol. 116; no. Pt B; pp. 388 - 413
• Main Authors: Phillips, Blaine W., Schlage, Walter K., Titz, Bjoern, Kogel, Ulrike, Sciuscio, Davide, Martin, Florian, Leroy, Patrice, Vuillaume, Gregory, Krishnan, Subash, Lee, Tom, Veljkovic, Emilija, Elamin, Ashraf, Merg, Celine, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia, Vanscheeuwijck, Patrick
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2018
• Subjects: Adaptive airway changes; Aerosols - toxicity; Animals; Biomarkers - blood; Biomarkers - urine; Body Weight - drug effects; Bronchoalveolar Lavage Fluid; Carbon; Clinical Chemistry Tests; Feeding Behavior - drug effects; Female; Heat-not-burn technology; Hematologic Tests; Hot Temperature; Inhalation Exposure; Lung inflammation; Male; Modified risk tobacco product; Nasal Mucosa - drug effects; Nasal Mucosa - pathology; Nicotiana; Organ Size - drug effects; Rats, Sprague-Dawley; Respiratory System - drug effects; Respiratory System - pathology; Respiratory System - physiopathology; Smoke - adverse effects; Systemic effects; Toxicity Tests; Systemic effects; Lung inflammation; Adaptive airway changes; Heat-not-burn technology; Modified risk tobacco product

Within the framework of a systems toxicology approach, the inhalation toxicity of aerosol from a novel tobacco-heating potentially modified risk tobacco product (MRTP), the carbon-heated tobacco product (CHTP) 1.2, was characterized and compared with that of mainstream smoke (CS) from the 3R4F refer...