Genetics of Renal Hypoplasia: Insights Into the Mechanisms Controlling Nephron Endowment

• Published in: Pediatric research Vol. 68; no. 2; pp. 91 - 98
• Main Authors: Cain, Jason E, Di Giovanni, Valeria, Smeeton, Joanna, Rosenblum, Norman D
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.08.2010; Lippincott Williams & Wilkins
• Subjects: Animals; Biological and medical sciences; Cell Differentiation; Cell Lineage; Cell Survival; Environment; Female; Humans; Kidney - abnormalities; Kidney - anatomy & histology; Kidney - embryology; Kidney Diseases - etiology; Kidney Diseases - genetics; Kidney Diseases - pathology; Kidneys; Malformations of the urinary system; Medical sciences; Medicine; Medicine & Public Health; Mesoderm - anatomy & histology; Mesoderm - physiology; Mutation; Nephrology. Urinary tract diseases; Nephrons - abnormalities; Nephrons - anatomy & histology; Nephrons - embryology; Pediatric Surgery; Pediatrics; Pregnancy; Prenatal Exposure Delayed Effects; review; Stem Cells - cytology; Stem Cells - physiology; Stromal Cells - cytology; Stromal Cells - physiology; Ureter - cytology; Kidney disease; Human; Pediatrics; Urinary system disease; Pathogenesis; Rodentia; Kidney hypoplasia; Review; Congenital disease; Vertebrata; Mammalia; Mouse; Malformation; Animal; Development; Nephron; Genetics

Renal hypoplasia, defined as abnormally small kidneys with normal morphology and reduced nephron number, is a common cause of pediatric renal failure and adult-onset disease. Genetic studies performed in humans and mutant mice have implicated a number of critical genes, in utero environmental factor...