Effect on Sodium/Iodide Symporter and Pendrin in Thyroid Colloid Retention Developed by Excess Iodide Intake

• Published in: Biological trace element research Vol. 172; no. 1; pp. 193 - 200
• Main Authors: Chen, Xiao-yi, Chu-hui Lin, Li-hua Yang, Wang-gen Li, Jin-wei Zhang, Wen-wei Zheng, Xiang Wang, Jiang Qian, Jia-luan Huang, Yi-xiong Lei
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2016; Springer Nature B.V
• Subjects: Animals; Anion Transport Proteins - antagonists & inhibitors; Anion Transport Proteins - genetics; Anion Transport Proteins - metabolism; Biochemistry; Biomedical and Life Sciences; Biotechnology; Colloids - chemistry; Colloids - metabolism; Female; females; goiter; Iodides; Iodides - administration & dosage; Iodides - pharmacology; Iodine; Life Sciences; mechanism of action; Mice; Mice, Inbred BALB C; mitochondria; Nutrition; Oncology; Retention; Rodents; Sodium; Sulfate Transporters; symporters; Symporters - antagonists & inhibitors; Symporters - genetics; Symporters - metabolism; Thyroid; thyroid function; Thyroid gland; Thyroid Gland - drug effects; Thyroid Gland - metabolism; Thyroid Gland - pathology; Toxicity; transmission electron microscopy; urine; Thyroid colloid retention; Excess iodide; Sodium/iodide symporter; Pendrin
• ISSN: 0163-4984; 1559-0720
• DOI: 10.1007/s12011-015-0580-4

It is well known that excess iodide can lead to thyroid colloid retention, a classic characteristic of iodide-induced goiter. However, the mechanism has not been fully unrevealed. Iodide plays an important role in thyroid function at multiple steps of thyroid colloid synthesis and transport among which sodium/iodide symporter (NIS) and pendrin are essential. In our study, we fed female BALB/c mice with different concentrations of high-iodine water including group A (control group, 0 μg/L), group B (1500 μg/L), group C (3000 μg/L), group D (6000 μg/L), and group E (12,000 μg/L). After 7 months of feeding, we found that excess iodide could lead to different degrees of thyroid colloid retention. Besides, NIS and pendrin expression were downregulated in the highest dose group. The thyroid iodide intake function detected by urine iodine assay and thyroidal ¹²⁵I experiments showed that the urine level of iodine increased, while the iodine intake rate decreased when the concentration of iodide used in feeding water increased (all p