Tbx1 is expressed at multiple sites of epithelial-mesenchymal interaction during early development of the facial complex

• Published in: The International journal of developmental biology Vol. 50; no. Next; p. 504
• Main Authors: Zoupa, Maria, Seppala, Maisa, Mitsiadis, Thimios, Cobourne, Martyn T.
• Format: Journal Article
• Language: English
• Published: Spain 2006
• Subjects: Animals; DiGeorge Syndrome - embryology; DiGeorge Syndrome - genetics; Epithelium - embryology; Epithelium - metabolism; Facial Bones - embryology; Facial Bones - metabolism; Female; Gene Expression Regulation, Developmental; Hair Follicle - embryology; Hair Follicle - metabolism; Humans; In Situ Hybridization; Mesoderm - metabolism; Mice; Pregnancy; T-Box Domain Proteins - genetics; Tooth Germ - embryology; Tooth Germ - metabolism

TBX1 encodes a T-box-containing transcription factor, which is thought to be a key player in the aetiology of the DiGeorge and Velocardiofacial syndromes (DGS/VCFS). In addition to defects affecting structures derived from the pharyngeal pouches, these patients exhibit varying degrees of facial dysm...