In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues

• Published in: Bioorganic & medicinal chemistry Vol. 26; no. 17; pp. 4898 - 4906
• Main Authors: Zimmermann-Franco, Danielle Cristina, Esteves, Bruna, Lacerda, Leticia Moroni, Souza, Isabela de Oliveira, Santos, Juliana Alves dos, Pinto, Nícolas de Castro Campos, Scio, Elita, da Silva, Adilson David, Macedo, Gilson Costa
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.09.2018
• Subjects: Adjuvants, Immunologic - pharmacology; Analogues; Animals; Anti-inflammatory; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacokinetics; Anti-Inflammatory Agents - pharmacology; Antioxidants - pharmacology; Biological Availability; Biphenyl Compounds - metabolism; Cell Proliferation - drug effects; Cytokines - antagonists & inhibitors; Cytokines - biosynthesis; Down-Regulation - drug effects; Imine; Imines - chemistry; Immunomodulatory; Inflammation - prevention & control; Inflammation Mediators - antagonists & inhibitors; Inflammation Mediators - metabolism; Lymphocytes - cytology; Lymphocytes - drug effects; Major Histocompatibility Complex - drug effects; Mice; Mice, Inbred C57BL; Peroxidase - biosynthesis; Picrates - metabolism; RAW 264.7 Cells; Resveratrol; Resveratrol - analogs & derivatives; NO; MCP-1; OPD; DMSO; MHC; HTAB; MTT; AP-1; MPO; LPS; BSA; NF-κB; SD; IFN-γ; OD; Resveratrol; iNOS; IC; Immunomodulatory; v/v; 5-LOX; CCL-2; CD; IL; DPPH; Analogues; 1H NMR; Imine; 13C NMR; EDTA; COX; AR; TH; TNF-α; PMSF; TMS; HE; Anti-inflammatory; ELISA

[Display omitted] •Imines resveratrol analogues are less cytotoxicity than thioimines and hydrazones.•The imines are more effective than resveratrol on DPPH scavenger.•The imines reduce pro-inflammatory mediators production in vitro.•The imines decrease lymphocyte proliferation and costimulatory mol...