Site of the action of a synthetic atrial natriuretic peptide evaluated in humans

• Published in: Kidney international Vol. 32; no. 4; pp. 537 - 546
• Main Authors: Biollaz, Jérôme, Bidiville, Jacques, Diézi, Jacques, Waeber, Bernard, Nussberger, Jürg, Brunner–Ferber, Françoise, Gomez, Hector J., Brunner, Hans R.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.10.1987; Nature Publishing
• Subjects: Adult; Atrial Natriuretic Factor - administration & dosage; Atrial Natriuretic Factor - pharmacology; Biological and medical sciences; Diuresis - drug effects; Eicosanoic Acids - administration & dosage; Eicosanoic Acids - pharmacology; Fundamental and applied biological sciences. Psychology; Glomerular Filtration Rate - drug effects; Humans; Infusions, Intravenous; Kidney Tubules - drug effects; Kidney Tubules, Distal - drug effects; Kidney Tubules, Distal - metabolism; Kidney Tubules, Proximal - drug effects; Kidney Tubules, Proximal - metabolism; Lithium - pharmacokinetics; Lithium - urine; Male; Natriuresis - drug effects; Peptide Fragments - administration & dosage; Peptide Fragments - pharmacology; Renal Circulation - drug effects; Vertebrates: urinary system; Human; Urine; Glomerular filtration; Urinary system; Sodium; Peptide hormone; Nephron; Reabsorption; Clearance; Inorganic element; Atrial natriuretic factor; Kidney

Site of the action of a synthetic atrial natriuretic peptide evaluated in humans. The renal site of the natriuretic effect of human, atrial natriuretic peptide (hANP) was studied using clearance techniques in eight salt–loaded normal volunteers undergoing maximal water diuresis. Lithium was used as...