Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds - Ortuzar, Natalia; Karu, Kersti; Presa, Daniela; Morais, Goreti R.; Sheldrake, Helen M.; Shnyder, Steve D.; Barnieh, Francis M.; Loadman, Paul M.; Patterson, Laurence H.; Pors, Klaus; Searcey, Mark (Bioorganic & medicinal chemistry, 2021)
Keywords: Bioactivation; Biochemistry & Molecular Biology; Bioprecursor; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Cytochrome P450; Cytotoxicity; Duocarmycin; Life Sciences & Biomedicine; Pharmacology & Pharmacy; Physical Sciences; Science & Technology; Duocarmycin; Cytotoxicity; Bioprecursor; Cytochrome P450; Bioactivation; DNA ALKYLATION; PYRINDAMYCIN ALKYLATION SUBUNIT; ACTIVATION; ANALOGS; MECHANISMS; CC-1065; IDENTIFICATION; BIZELESIN; PHARMACOPHORE; PHASE-I