Reactive hyperemia: a review of methods, mechanisms, and considerations
Reactive hyperemia is a well-established technique for noninvasive assessment of peripheral microvascular function and a predictor of all-cause and cardiovascular morbidity and mortality. In its simplest form, reactive hyperemia represents the magnitude of limb reperfusion following a brief period o...
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| Published in | American journal of physiology. Regulatory, integrative and comparative physiology Vol. 318; no. 3; pp. R605 - R618 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.03.2020
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| Online Access | Get full text |
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| Abstract | Reactive hyperemia is a well-established technique for noninvasive assessment of peripheral microvascular function and a predictor of all-cause and cardiovascular morbidity and mortality. In its simplest form, reactive hyperemia represents the magnitude of limb reperfusion following a brief period of ischemia induced by arterial occlusion. Over the past two decades, investigators have employed a variety of methods, including brachial artery velocity by Doppler ultrasound, tissue reperfusion by near-infrared spectroscopy, limb distension by venous occlusion plethysmography, and peripheral artery tonometry, to measure reactive hyperemia. Regardless of the technique used to measure reactive hyperemia, blunted reactive hyperemia is believed to reflect impaired microvascular function. With the advent of several technological advancements, together with an increased interest in the microcirculation, reactive hyperemia is becoming more common as a research tool and is widely used across multiple disciplines. With this in mind, we sought to review the various methodologies commonly used to assess reactive hyperemia and current mechanistic pathways believed to contribute to reactive hyperemia and reflect on several methodological considerations. |
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| AbstractList | Reactive hyperemia is a well-established technique for noninvasive assessment of peripheral microvascular function and a predictor of all-cause and cardiovascular morbidity and mortality. In its simplest form, reactive hyperemia represents the magnitude of limb reperfusion following a brief period of ischemia induced by arterial occlusion. Over the past two decades, investigators have employed a variety of methods, including brachial artery velocity by Doppler ultrasound, tissue reperfusion by near-infrared spectroscopy, limb distension by venous occlusion plethysmography, and peripheral artery tonometry, to measure reactive hyperemia. Regardless of the technique used to measure reactive hyperemia, blunted reactive hyperemia is believed to reflect impaired microvascular function. With the advent of several technological advancements, together with an increased interest in the microcirculation, reactive hyperemia is becoming more common as a research tool and is widely used across multiple disciplines. With this in mind, we sought to review the various methodologies commonly used to assess reactive hyperemia and current mechanistic pathways believed to contribute to reactive hyperemia and reflect on several methodological considerations. |
| Author | Nelson, Michael D Rosenberry, Ryan |
| Author_xml | – sequence: 1 givenname: Ryan surname: Rosenberry fullname: Rosenberry, Ryan organization: Department of Kinesiology, University of Texas at Arlington, Arlington, Texas – sequence: 2 givenname: Michael D orcidid: 0000-0002-3232-8639 surname: Nelson fullname: Nelson, Michael D organization: Department of Bioengineering, University of Texas at Arlington, Arlington, Texas |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32022580$$D View this record in MEDLINE/PubMed |
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