Hydroalcoholic extract of Tagetes minuta L. inhibits inflammatory bowel disease through the activity of pheophytins on the NF-κB signalling pathway

• Published in: Journal of ethnopharmacology Vol. 268; p. 113603
• Main Authors: Apaza Ticona, Luis, Lacheva, Ginka Ilieva, Serban, Andreea Madalina, Rumbero Sánchez, Ángel
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 25.03.2021
• Subjects: Anti-inflammatory; Anti-Inflammatory Agents - isolation & purification; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Cell Line; Dose-Response Relationship, Drug; Ethanol - isolation & purification; Ethanol - pharmacology; Ethanol - therapeutic use; Humans; Inflammatory Bowel Diseases - drug therapy; Inflammatory Bowel Diseases - metabolism; NF-kappa B - antagonists & inhibitors; NF-kappa B - metabolism; NF-κB; Pheophytins; Pheophytins - isolation & purification; Pheophytins - pharmacology; Pheophytins - therapeutic use; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Signal Transduction - drug effects; Signal Transduction - physiology; Tagetes; Tagetes minuta; TNF-α; Water - pharmacology; Pheophytins; NF-κB; Tagetes minuta; TNF-α; Anti-inflammatory

Species of the genus Tagetes are well known for their anti-inflammatory properties. Tagetes minuta “Huacatay” is an endemic species of South America that has been used in traditional medicine since ancient times as a remedy for stomach and intestinal discomfort. The aim of this study is to investiga...