Effect of low-dose aspirin administration on long-term survival of cirrhotic patients after splenectomy: A retrospective single-center study

• Published in: World journal of gastroenterology : WJG Vol. 25; no. 28; pp. 3798 - 3807
• Main Authors: Du, Zhao-Qing, Zhao, Jun-Zhou, Dong, Jian, Bi, Jian-Bin, Ren, Yi-Fan, Zhang, Jia, Khalid, Bilawal, Wu, Zheng, Lv, Yi, Zhang, Xu-Feng, Wu, Rong-Qian
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 28.07.2019
• Subjects: Adult; Aged; Aspirin - administration & dosage; Carcinoma, Hepatocellular - epidemiology; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - prevention & control; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Hypersplenism - etiology; Hypersplenism - surgery; Hypertension, Portal - etiology; Hypertension, Portal - surgery; Incidence; Liver Cirrhosis - complications; Liver Cirrhosis - mortality; Liver Cirrhosis - surgery; Liver Neoplasms - epidemiology; Liver Neoplasms - pathology; Liver Neoplasms - prevention & control; Male; Middle Aged; Platelet Aggregation Inhibitors - administration & dosage; Portal Vein - pathology; Prognosis; Retrospective Studies; Retrospective Study; Splenectomy - adverse effects; Time Factors; Venous Thrombosis - etiology; Venous Thrombosis - prevention & control; Young Adult; Splenectomy; Hepatocellular carcinoma; Aspirin; Prognosis; Overall survival

Cirrhosis is a major risk factor for the development of hepatocellular carcinoma (HCC). Portal vein thrombosis is not uncommon after splenectomy in cirrhotic patients, and many such patients take oral anticoagulants including aspirin. However, the long-term impact of postoperative aspirin on cirrhot...