Effect of low-dose aspirin administration on long-term survival of cirrhotic patients after splenectomy: A retrospective single-center study

• Published in: World journal of gastroenterology : WJG Vol. 25; no. 28; pp. 3798 - 3807
• Main Authors: Du, Zhao-Qing, Zhao, Jun-Zhou, Dong, Jian, Bi, Jian-Bin, Ren, Yi-Fan, Zhang, Jia, Khalid, Bilawal, Wu, Zheng, Lv, Yi, Zhang, Xu-Feng, Wu, Rong-Qian
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 28.07.2019
• Subjects: Adult; Aged; Aspirin - administration & dosage; Carcinoma, Hepatocellular - epidemiology; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - prevention & control; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Hypersplenism - etiology; Hypersplenism - surgery; Hypertension, Portal - etiology; Hypertension, Portal - surgery; Incidence; Liver Cirrhosis - complications; Liver Cirrhosis - mortality; Liver Cirrhosis - surgery; Liver Neoplasms - epidemiology; Liver Neoplasms - pathology; Liver Neoplasms - prevention & control; Male; Middle Aged; Platelet Aggregation Inhibitors - administration & dosage; Portal Vein - pathology; Prognosis; Retrospective Studies; Retrospective Study; Splenectomy - adverse effects; Time Factors; Venous Thrombosis - etiology; Venous Thrombosis - prevention & control; Young Adult; Splenectomy; Hepatocellular carcinoma; Aspirin; Prognosis; Overall survival
• DOI: 10.3748/wjg.v25.i28.3798
• ISSN: 1007-9327

Cirrhosis is a major risk factor for the development of hepatocellular carcinoma (HCC). Portal vein thrombosis is not uncommon after splenectomy in cirrhotic patients, and many such patients take oral anticoagulants including aspirin. However, the long-term impact of postoperative aspirin on cirrhotic patients after splenectomy remains unknown. The main purpose of this study was to investigate the effect of postoperative long-term low-dose aspirin administration on the development of HCC and long-term survival of cirrhotic patients after splenectomy. The clinical data of 264 adult patients with viral hepatitis-related cirrhosis who underwent splenectomy at the First Affiliated Hospital of Xi'an Jiaotong University from January 2000 to December 2014 were analyzed retrospectively. Among these patients, 59 who started taking 100 mg/d aspirin within seven days were enrolled in the aspirin group. The incidence of HCC and overall survival were analyzed. During follow-up, 41 (15.53%) patients developed HCC and 37 (14.02%) died due to end-stage liver diseases or other serious complications. Postoperative long-term low-dose aspirin therapy reduced the incidence of HCC from 19.02% to 3.40% after splenectomy (log-rank test, 0.028). Univariate and multivariate analyses showed that not undertaking postoperative long-term low-dose aspirin therapy [odds ratio (OR) = 6.211, 95% confidence interval (CI): 1.142-27.324, 0.016] was the only independent risk factor for the development of HCC. Similarly, patients in the aspirin group survived longer than those in the control group (log-rank test, 0.041). Univariate and multivariate analyses showed that the only factor that independently associated with improved overall survival was postoperative long-term low-dose aspirin therapy [OR = 0.218, 95%CI: 0.049-0.960, 0.044]. In patients with viral hepatitis-related cirrhosis, long-term post-splenectomy administration of low-dose aspirin reduces the incidence of HCC and improves the long-term overall survival.