Beyond active site residues: overall structural dynamics control catalysis in flavin-containing and heme-containing monooxygenases

• Published in: Current opinion in structural biology Vol. 59; pp. 29 - 37
• Main Authors: Fürst, Maximilian JLJ, Fiorentini, Filippo, Fraaije, Marco W
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2019

[Display omitted] •Monooxygenases (MOs) face a challenging reaction, requiring the coordination of three substrates by the same active site.•To address this challenge, these enzymes evolved various strategies involving structural flexibility.•Flavoprotein MOs use mobile flavin and nicotinamide cofac...