Real-time monitoring of etoposide prodrug activated by hydrogen peroxide with improved safety

• Published in: Journal of materials chemistry. B, Materials for biology and medicine Vol. 7; no. 47; pp. 7548 - 7557
• Main Authors: Zhu, Jiawen, Chen, Jingting, Song, Dongmei, Zhang, Wenda, Guo, Jianpeng, Cai, Guiping, Ren, Yuhao, Wan, Chengying, Kong, Lingyi, Yu, Wenying
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 21.12.2019
• Subjects: adverse effects; animal disease models; Aromatic compounds; borates; Cancer; chemistry; Chemotherapy; Coumarin; Danio rerio; Drug delivery systems; drug therapy; Etoposide; Fluorescence; Hydrogen peroxide; monitoring; neoplasm cells; neoplasms; Real time; Safety; Side effects; Zebrafish

Etoposide is one of the most used first-line chemotherapeutic drugs. However, its application is still limited by its side effects. Herein, we designed a novel H 2 O 2 sensitive prodrug 6YT for selectively releasing the anti-cancer drug etoposide in cancer cells. In this paper, etoposide and a hydro...