CD100–Plexin-B2 Promotes the Inflammation in Psoriasis by Activating NF-κB and the Inflammasome in Keratinocytes

• Published in: Journal of investigative dermatology Vol. 138; no. 2; pp. 375 - 383
• Main Authors: Zhang, Chen, Xiao, Chunying, Dang, Erle, Cao, Jiao, Zhu, Zhenlai, Fu, Meng, Yao, Xu, Liu, Yufeng, Jin, Boquan, Wang, Gang, Li, Wei
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2018
• Subjects: sCD100; AD; mCD100; Th; qRT-PCR; siRNA; IMQ

PlxnB2 and its ligand, CD100, were originally identified as axon-guidance molecules that function during neuronal development; however, studies also showed that CD100-plexins participate in various immune responses. In this study, we found that the expression of PlxnB2 on keratinocytes was specifica...