Rodent diet aids and the fallacy of caloric restriction

• Published in: Mechanisms of ageing and development Vol. 200; p. 111584
• Main Author: Wolf, Alexander M.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.12.2021
• Subjects: Aging; Aging - physiology; Animals; Caloric Restriction; Caloric restriction mimetics; Energy Intake - physiology; Healthy Aging - physiology; Humans; Life span; Longevity - drug effects; Mice; Obesity; Obesity - diet therapy; Obesity - drug therapy; Obesity - metabolism; Obesity - mortality; Senotherapeutics - pharmacology; Survival Analysis; Aging; Obesity; Life span; Caloric restriction mimetics; Caloric restriction

•Caloric restriction extends life span mostly by reducing excess mortality due to obesity.•Most pharmacologic interventions to slow aging, including resveratrol, rapamycin, NAD + and metformin, also cause weight loss.•Dietary restriction and weight loss is beneficial only for obese subjects.•Investi...