Yi-Shen-Hua-Shi granule ameliorates diabetic kidney disease by the “gut-kidney axis”

• Published in: Journal of ethnopharmacology Vol. 307; p. 116257
• Main Authors: Han, Cong, Shen, Zhen, Cui, Tao, Ai, Shan-shan, Gao, Ran-ran, Liu, Yao, Sui, Gui-yuan, Hu, Hong-zhen, Li, Wei
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 10.05.2023
• Subjects: 16S rDNA sequencing; Animals; Blood Glucose; Chromatography, Liquid; Diabetes Mellitus; Diabetic kidney disease; Diabetic Nephropathies; Glucose; Glycerophospholipids; Gut-kidney axis; Herbal Medicine; Kidney - physiology; LC-MS/MS; Rats; RNA-seq; Saline Solution; Sphingolipids; Tandem Mass Spectrometry; Tryptophan; Valsartan; Yi-Shen-Hua-Shi granule; LC-MS/MS; 16S rDNA sequencing; Yi-Shen-Hua-Shi granule; RNA-seq; Gut-kidney axis; Diabetic kidney disease

Yi-Shen-Hua-Shi (YSHS) granule is an effective prescription widely used in traditional Chinese medicine to treat diabetic kidney disease (DKD), its exact efficacy in treating DKD has been confirmed but the underlying regulatory mechanism has not been fully elucidated. To explore the mechanism by whi...