Increased homocysteine levels correlate with cortical structural damage in Parkinson's disease

• Published in: Journal of the neurological sciences Vol. 434; p. 120148
• Main Authors: Sampedro, Frederic, Martínez-Horta, Saul, Horta-Barba, Andrea, Grothe, Michel J., Labrador-Espinosa, Miguel A., Jesús, Silvia, Adarmes-Gómez, Astrid, Carrillo, Fátima, Puig-Davi, Arnau, Lora, Florinda Roldán, Barberá, Miquel Aguilar, Pastor, Pau, Arroyo, Sonia Escalante, Vila, Berta Solano, Foraster, Anna Cots, Martínez, Javier Ruiz, Padilla, Francisco Carrillo, Morlans, Mercedes Pueyo, Aramburu, Isabel González, Ceberio, Jon Infante, Vara, Jorge Hernández, de Fábregues-Boixar, Oriol, de Deus Fonticoba, Teresa, Ávila, Asunción, Martínez-Castrillo, Juan Carlos, Bejr-Kasem, Helena, Campolongo, Antonia, Pascual-Sedano, Berta, Martínez-Martín, Pablo, Santos-García, Diego, Mir, Pablo, Kulisevsky, Jaime
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.03.2022
• Subjects: Cerebral Cortex - diagnostic imaging; Cerebral Cortex - pathology; Cerebral Cortical Thinning; Homocysteine; Humans; Magnetic Resonance Imaging; Neuroimaging; Parkinson Disease - complications; Parkinson's disease; Neuroimaging; Homocysteine; Parkinson's disease

Blood homocysteine appears to be increased in Parkinson's disease (PD) and may play a role in the development and progression of this disorder. However, the specific contribution of abnormal homocysteine levels to cortical degeneration in PD remains elusive. To characterize the cortical structu...