N6-Methyladenosine Modification of Fatty Acid Amide Hydrolase Messenger RNA in Circular RNA STAG1–Regulated Astrocyte Dysfunction and Depressive-like Behaviors

• Published in: Biological psychiatry (1969) Vol. 88; no. 5; pp. 392 - 404
• Main Authors: Huang, Rongrong, Zhang, Yuan, Bai, Ying, Han, Bing, Ju, Minzi, Chen, Biling, Yang, Li, Wang, Yu, Zhang, Hongxing, Zhang, Haisan, Xie, Chunming, Zhang, Zhijun, Yao, Honghong
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.09.2020
• Subjects: ALKBH5; Astrocyte; circSTAG1; Depression; FAAH; N6-methyladenosine; Depression; ALKBH5; circSTAG1; FAAH; N6-methyladenosine; Astrocyte

N6-methyladenosine (m6A) is the most abundant epigenetic modification in eukaryotic messenger RNAs and is essential for multiple RNA processing events in physiological and pathological processes. However, precisely how m6A methylation is involved in major depressive disorder (MDD) is not fully under...