Two variants on T2DM susceptible gene HHEX are associated with CRC risk in a Chinese population

• Published in: Oncotarget Vol. 7; no. 20; pp. 29770 - 29779
• Main Authors: Sun, Rui, Liu, Jian-Ping, Gao, Chang, Xiong, Ying-Ying, Li, Min, Wang, Ya-Ping, Su, Yan-Wei, Lin, Mei, Jiang, An-Li, Xiong, Ling-Fan, Xie, Yan, Feng, Jue-Ping
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 17.05.2016
• Subjects: Asian Continental Ancestry Group - genetics; Colorectal Neoplasms - genetics; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - genetics; Female; Genetic Predisposition to Disease - genetics; Genotype; Homeodomain Proteins - genetics; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Research Paper; Risk Factors; Transcription Factors - genetics; genetic variants; type 2 diabetes mellitus; HHEX; colorectal cancer

Increasing amounts of evidence has demonstrated that T2DM (Type 2 Diabetes Mellitus) patients have increased susceptibility to CRC (colorectal cancer). As HHEX is a recognized susceptibility gene in T2DM, this work was focused on two SNPs in HHEX, rs1111875 and rs7923837, to study their association...