Blood-brain barrier dysfunction mediated by the EZH2-Claudin-5 axis drives stress-induced TNF-α infiltration and depression-like behaviors

• Published in: Brain, behavior, and immunity Vol. 115; pp. 143 - 156
• Main Authors: Sun, Zhao-Wei, Wang, Xue, Zhao, Yun, Sun, Zhao-Xin, Wu, Yu-Han, Hu, Hui, Zhang, Ling, Wang, Shi-Da, Li, Feng, Wei, Ai-Jun, Feng, Hong, Xie, Fang, Qian, Ling-Jia
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.01.2024
• Subjects: Blood–brain barrier; Chronic stress; Depression; EZH2-Claudin-5 axis; H3K27me3 modification; TNF-α; Depression; Chronic stress; EZH2-Claudin-5 axis; TNF-α; H3K27me3 modification; Blood–brain barrier

•CUMS mice exhibits hippocampal BBB dysfunction accompanied with loss of Cldn5.•Enhanced recruitment of EZH2-dependent H3K27me3 modification at the Cldn5 promoter triggers its transcriptional repression and the subsequent depression in stressed individuals.•Chronic stress-induced BBB hyperpermeabili...