Autophagy protects gastric mucosal epithelial cells from ethanol-induced oxidative damage via mTOR signaling pathway

• Published in: Experimental biology and medicine (Maywood, N.J.) Vol. 242; no. 10; pp. 1025 - 1033
• Main Authors: Chang, Weilong, Bai, Jie, Tian, Shaobo, Ma, Muyuan, Li, Wei, Yin, Yuping, Deng, Rui, Cui, Jinyuan, Li, Jinjin, Wang, Guobin, Zhang, Peng, Tao, Kaixiong
• Format: Journal Article
• Language: English
• Published: England SAGE Publications 01.05.2017
• Subjects: Animals; Autophagy; Epithelial Cells - drug effects; Ethanol - toxicity; Gastric Mucosa - drug effects; Original Research; Rats, Wistar; Signal Transduction; TOR Serine-Threonine Kinases - metabolism; mTOR signaling pathway; gastric mucosal epithelial cells; Autophagy; ethanol; oxidative stress

Alcohol abuse is an important cause of gastric mucosal epithelial cell injury and gastric ulcers. A number of studies have demonstrated that autophagy, an evolutionarily conserved cellular mechanism, has a protective effect on cell survival. However, it is not known whether autophagy can protect gas...