Night workers with circadian misalignment are susceptible to alcohol-induced intestinal hyperpermeability with social drinking

• Published in: American journal of physiology: Gastrointestinal and liver physiology Vol. 311; no. 1; pp. G192 - G201
• Main Authors: Swanson, Garth R., Gorenz, Annika, Shaikh, Maliha, Desai, Vishal, Kaminsky, Thomas, Van Den Berg, Jolice, Murphy, Terrence, Raeisi, Shohreh, Fogg, Louis, Vitaterna, Martha Hotz, Forsyth, Christopher, Turek, Fred, Burgess, Helen J., Keshavarzian, Ali
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.07.2016
• Subjects: Adult; Alcohol Drinking - adverse effects; Biomarkers - blood; Circadian Rhythm; Circadian Rhythm Signaling Peptides and Proteins - blood; Circadian Rhythm Signaling Peptides and Proteins - genetics; Colon - drug effects; Colon - metabolism; Colon - physiopathology; Gene Expression Regulation; Humans; Inflammation Mediators - blood; Intestine, Small - drug effects; Intestine, Small - metabolism; Intestine, Small - physiopathology; Melatonin - blood; Middle Aged; Permeability; Personnel Staffing and Scheduling; Sleep; Sleep Disorders, Circadian Rhythm - blood; Sleep Disorders, Circadian Rhythm - complications; Sleep Disorders, Circadian Rhythm - diagnosis; Sleep Disorders, Circadian Rhythm - physiopathology; Time Factors; Translational Human Pathophysiology; Work Schedule Tolerance; Young Adult; melatonin; alcoholic liver disease; intestinal permeability

Alcohol-induced intestinal hyperpermeability (AIHP) is a known risk factor for alcoholic liver disease (ALD), but only 20–30% of heavy alcoholics develop AIHP and ALD. The hypothesis of this study is that circadian misalignment would promote AIHP. We studied two groups of healthy subjects on a stabl...