Intrauterine Progestin Therapy as a New Approach to Premalignant Endometrial Polyps: A Prospective Observational Study

• Published in: Anticancer research Vol. 39; no. 9; pp. 4897 - 4903
• Main Authors: SLETTEN, ELISE THORESEN, ARNES, MARIT, VEREIDE, ANNE BEATE, ØRBO, ANNE
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.09.2019; International Institute of Anticancer Research (IIAR)
• Subjects: Adult; Aged; Antineoplastic Agents, Hormonal - administration & dosage; Biomarkers; Biopsy; Body mass index; Endometrial Hyperplasia - drug therapy; Endometrial Hyperplasia - pathology; Endometrium; Estrogens; Female; Humans; Hyperplasia; Hysterectomy; Medical disciplines: 700; Medisinske Fag: 700; Microscopy; Middle Aged; Observational studies; Patients; Pilot Projects; Polyps; Polyps - pathology; Precancerous Conditions - drug therapy; Precancerous Conditions - pathology; Progestin; Progestins - administration & dosage; Progestins - adverse effects; Prospective Studies; Risk; Therapy; Treatment Outcome; Uterine cancer; VDP; Berlin Germany; Norway; Germany; Endometrial polyps; LNG-IUS; progestin therapy

Endometrial hyperplastic polyps (EHP) may progress to endometrial carcinoma (EC) if left untreated. We aimed to prospectively investigate the efficacy of the low-dose levonorgestrel intrauterine system (LNG-IUS) as therapy for EHP with malignant potential. In total, 37 women with EHP underwent thera...