Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue - Green, Jonathan; Tinson, Ryan A.J.; Betts, Jacob H.J.; Piras, Monica; Pelut, Aylin; Steverding, Dietmar; Wren, Stephen P.; Searcey, Mark; Troeberg, Linda (Bioorganic & medicinal chemistry, 2023)
Keywords: Biochemistry & Molecular Biology; Cartilage - metabolism; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Humans; Life Sciences & Biomedicine; Low-density lipoprotein receptor-related protein 1; LRP1; Metalloproteases - metabolism; Metalloproteases - pharmacology; Metalloproteases - therapeutic use; Osteoarthritis; Osteoarthritis - drug therapy; Osteoarthritis - metabolism; Pharmacology & Pharmacy; Physical Sciences; Science & Technology; Suramin; Suramin - metabolism; Suramin - pharmacology; Suramin - therapeutic use; TIMP-3; Tissue Inhibitor of Metalloproteinase-3 - metabolism; Tissue Inhibitor of Metalloproteinase-3 - pharmacology; Tissue Inhibitor of Metalloproteinase-3 - therapeutic use; EtOAc; RAP; TIMP-3; Suramin; RT; SDS; LRP1; TBS; IL1β; ADAMTS; Low-density lipoprotein receptor-related protein 1; GAG; MTS; PVDF; CR; DMEM; MMP; OA; TCA; FCS; Osteoarthritis; DMMB; ENDOCYTOSIS; DELIVERY; NANOPARTICLES; AGGRECANASE; RESISTANT; ADAMTS5; IN-VIVO; DEGRADATION; BINDING; SULFATED GLYCOSAMINOGLYCANS