Resistance of cholangiocarcinoma cells to parthenolide-induced apoptosis by the excretory-secretory products of Clonorchis sinensis

• Published in: Parasitology research (1987) Vol. 104; no. 5; pp. 1011 - 1016
• Main Authors: Kim, Young Ju, Choi, Min-Ho, Hong, Sung-Tae, Bae, Young Mee
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.04.2009; Springer-Verlag; Springer
• Subjects: Animals; Antineoplastic Agents - pharmacology; Apoptosis; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cell Line, Tumor; Cell Proliferation - drug effects; Clonorchis sinensis - physiology; Cyclooxygenase 2 - biosynthesis; Drug Resistance; Fundamental and applied biological sciences. Psychology; General aspects; General aspects and techniques. Study of several systematic groups. Models; Helminth Proteins - metabolism; Humans; Immunology; Invertebrates; Medical Microbiology; Microbiology; Original Paper; Sesquiterpenes - pharmacology; Liver Fluke; Parthenolide; Sesquiterpene Lactone; Cholangiocarcinoma; Phenazine Methosulfate; Sensitivity resistance; Helmintha; Plathelmintha; Parasite; Clonorchis sinensis; Invertebrata; Trematoda; Apoptosis

Infection by Clonorchis sinensis, the Chinese or oriental liver fluke, is a significant risk factor for the development of cholangiocarcinoma, a human epithelial carcinoma of the intrahepatic bile duct. Parthenolide is a sesquiterpene lactone that has strong anticancer properties and is also known t...