Characterisation of allergen-specific responses of IL-10-producing regulatory B cells (Br1) in Cow Milk Allergy

• Published in: Cellular immunology Vol. 264; no. 2; pp. 143 - 149
• Main Authors: Noh, Joonyong, Lee, Jae Ho, Noh, Geunwoong, Bang, So Young, Kim, Hyuk Soon, Choi, Wahn Soo, Cho, Sunheui, Lee, Sang Sun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 2010
• Subjects: Adolescent; Adult; Allergens; Allergens - immunology; Animals; Antigens, CD19 - biosynthesis; Apoptosis; Apoptosis - immunology; Atopic dermatitis; B-Lymphocyte Subsets - immunology; B-Lymphocyte Subsets - metabolism; B-Lymphocyte Subsets - pathology; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; B-Lymphocytes - pathology; Br1; Caseins - immunology; Cattle; CD5; CD5 Antigens - biosynthesis; Cell Count; Cells, Cultured; Child; Child, Preschool; Female; Food allergy; Humans; IL-10; Immune Tolerance; Immunomodulation; Interleukin-10 - secretion; Late eczematous reaction; Male; Milk allergy; Milk Hypersensitivity - immunology; Milk Hypersensitivity - pathology; Milk Hypersensitivity - physiopathology; Regulatory B cell; Tolerance; Br1; Food allergy; Late eczematous reaction; Regulatory B cell; CD5; Atopic dermatitis; Tolerance; Milk allergy; IL-10; Apoptosis

CD19+CD5+ regulatory B cells regulate immune responses by producing IL-10. IL-10-producing regulatory B cell (Br1) responses by allergen stimulation were investigated in human food allergy. Six milk allergy patients and eight milk-tolerant subjects were selected according to DBPCFC. PBMCs were stimu...