Organ Preservation into the 2020s: The Era of Dynamic Intervention
Organ preservation has been of major importance ever since transplantation developed into a global clinical activity. The relatively simple procedures were developed on a basic comprehension of low-temperature biology as related to organs outside the body. In the past decade, there has been a signif...
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| Published in | Transfusion medicine and hemotherapy Vol. 46; no. 3; pp. 151 - 172 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Basel, Switzerland
S. Karger AG
01.06.2019
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1660-3796 1660-3818 |
| DOI | 10.1159/000499610 |
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| Abstract | Organ preservation has been of major importance ever since transplantation developed into a global clinical activity. The relatively simple procedures were developed on a basic comprehension of low-temperature biology as related to organs outside the body. In the past decade, there has been a significant increase in knowledge of the sequelae of effects in preserved organs, and how dynamic intervention by perfusion can be used to mitigate injury and improve the quality of the donated organs. The present review focuses on (1) new information about the cell and molecular events impacting on ischemia/reperfusion injury during organ preservation, (2) strategies which use varied compositions and additives in organ preservation solutions to deal with these, (3) clear definitions of the developing protocols for dynamic organ perfusion preservation, (4) information on how the choice of perfusion solutions can impact on desired attributes of dynamic organ perfusion, and (5) summary and future horizons. |
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| AbstractList | Organ preservation has been of major importance ever since transplantation developed into a global clinical activity. The relatively simple procedures were developed on a basic comprehension of low-temperature biology as related to organs outside the body. In the past decade, there has been a significant increase in knowledge of the sequelae of effects in preserved organs, and how dynamic intervention by perfusion can be used to mitigate injury and improve the quality of the donated organs. The present review focuses on (1) new information about the cell and molecular events impacting on ischemia/reperfusion injury during organ preservation, (2) strategies which use varied compositions and additives in organ preservation solutions to deal with these, (3) clear definitions of the developing protocols for dynamic organ perfusion preservation, (4) information on how the choice of perfusion solutions can impact on desired attributes of dynamic organ perfusion, and (5) summary and future horizons.Organ preservation has been of major importance ever since transplantation developed into a global clinical activity. The relatively simple procedures were developed on a basic comprehension of low-temperature biology as related to organs outside the body. In the past decade, there has been a significant increase in knowledge of the sequelae of effects in preserved organs, and how dynamic intervention by perfusion can be used to mitigate injury and improve the quality of the donated organs. The present review focuses on (1) new information about the cell and molecular events impacting on ischemia/reperfusion injury during organ preservation, (2) strategies which use varied compositions and additives in organ preservation solutions to deal with these, (3) clear definitions of the developing protocols for dynamic organ perfusion preservation, (4) information on how the choice of perfusion solutions can impact on desired attributes of dynamic organ perfusion, and (5) summary and future horizons. Organ preservation has been of major importance ever since transplantation developed into a global clinical activity. The relatively simple procedures were developed on a basic comprehension of low-temperature biology as related to organs outside the body. In the past decade, there has been a significant increase in knowledge of the sequelae of effects in preserved organs, and how dynamic intervention by perfusion can be used to mitigate injury and improve the quality of the donated organs. The present review focuses on (1) new information about the cell and molecular events impacting on ischemia/reperfusion injury during organ preservation, (2) strategies which use varied compositions and additives in organ preservation solutions to deal with these, (3) clear definitions of the developing protocols for dynamic organ perfusion preservation, (4) information on how the choice of perfusion solutions can impact on desired attributes of dynamic organ perfusion, and (5) summary and future horizons. |
| Author | Petrenko, Alexander Osorio, Juliana Fuller, Barry Guibert, Edgardo Somov, Alexander Froghi, Farid Carnevale, Matias Rodríguez, Joaquin |
| AuthorAffiliation | d UCL Division of Surgery and Interventional Sciences, Royal Free Hospital, London, United Kingdom c Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina a Department of Cryobiochemistry, Institute for Problems of Cryobiology and Cryomedicine, Ukraine Academy of Sciences, Kharkov, Ukraine b Centro Binacional (Argentina-Italia) de Investigaciones en Criobiología Clínica y Aplicada (CAIC), Universidad Nacional de Rosario, Rosario, Argentina |
| AuthorAffiliation_xml | – name: b Centro Binacional (Argentina-Italia) de Investigaciones en Criobiología Clínica y Aplicada (CAIC), Universidad Nacional de Rosario, Rosario, Argentina – name: c Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina – name: d UCL Division of Surgery and Interventional Sciences, Royal Free Hospital, London, United Kingdom – name: a Department of Cryobiochemistry, Institute for Problems of Cryobiology and Cryomedicine, Ukraine Academy of Sciences, Kharkov, Ukraine |
| Author_xml | – sequence: 1 givenname: Alexander surname: Petrenko fullname: Petrenko, Alexander – sequence: 2 givenname: Matias surname: Carnevale fullname: Carnevale, Matias – sequence: 3 givenname: Alexander surname: Somov fullname: Somov, Alexander – sequence: 4 givenname: Juliana surname: Osorio fullname: Osorio, Juliana – sequence: 5 givenname: Joaquin surname: Rodríguez fullname: Rodríguez, Joaquin – sequence: 6 givenname: Edgardo surname: Guibert fullname: Guibert, Edgardo – sequence: 7 givenname: Barry surname: Fuller fullname: Fuller, Barry – sequence: 8 givenname: Farid surname: Froghi fullname: Froghi, Farid email: farid.froghi@nhs.net |
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