Sex- and injury-based differences in knee biomechanics in mouse models of post-traumatic osteoarthritis

• Published in: Journal of biomechanics Vol. 114; p. 110152
• Main Authors: Blaker, Carina L., Ashton, Dylan M., Doran, Nathan, Little, Christopher B., Clarke, Elizabeth C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 04.01.2021; Elsevier Limited
• Subjects: ACL; Animal models; Animals; Anterior cruciate ligament; Arthritis; Biomechanics; Biomedical materials; DMM; Females; Injuries; Joint and ligament injuries; Joint mechanics; Joints (anatomy); Knee; Ligaments; Meniscus; Non-invasive model; Osteoarthritis; Pathogenesis; PTOA; Risk analysis; Risk factors; Sex; Stiffness; Surgical model; United States > US; Non-invasive model; ACL; PTOA; DMM; Joint mechanics; Surgical model

Sex and joint injury are risk factors implicated in the onset and progression of osteoarthritis (OA). In mouse models of post-traumatic OA (ptOA), the pathogenesis of disease is notably impacted by sex (often worse in males) and injury model (e.g. meniscal versus ligament injury). Increasing ptOA pr...