Sex- and injury-based differences in knee biomechanics in mouse models of post-traumatic osteoarthritis

Sex and joint injury are risk factors implicated in the onset and progression of osteoarthritis (OA). In mouse models of post-traumatic OA (ptOA), the pathogenesis of disease is notably impacted by sex (often worse in males) and injury model (e.g. meniscal versus ligament injury). Increasing ptOA pr...

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Published inJournal of biomechanics Vol. 114; p. 110152
Main Authors Blaker, Carina L., Ashton, Dylan M., Doran, Nathan, Little, Christopher B., Clarke, Elizabeth C.
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 04.01.2021
Elsevier Limited
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Abstract Sex and joint injury are risk factors implicated in the onset and progression of osteoarthritis (OA). In mouse models of post-traumatic OA (ptOA), the pathogenesis of disease is notably impacted by sex (often worse in males) and injury model (e.g. meniscal versus ligament injury). Increasing ptOA progression and severity is often associated with greater relative instability of the joint but few studies have directly quantified changes in joint mechanics after injury and compared outcomes across multiple models in both male and female mice. Passive anterior-posterior knee biomechanics were evaluated in 10-week-old, male and female C57BL/6J mice. PtOA injury models included destabilisation of the medial meniscus (DMM), anterior cruciate ligament transection (ACLT) or mechanical rupture (ACLR), and combined DMM and ACLT (DMM + ACLT). Sham operated and non-operated controls (NOC) were included for baseline comparisons. The test apparatus loaded hindlimbs at 60° flexion between ± 1 N at 0.5 mm/s (build specifications available for download: https://doi.org/10.17632/z754455x3c.1). Measures of joint laxity (range of motion, neutral zone) and stiffness were calculated. Joint laxity was comparable between male and female mice while joint stiffness was greater in females (P ≤ 0.002, correcting for body-mass and injury-model). Anterior-posterior joint mechanics were minimally altered by DMM but significantly affected by loss of the ACL (P < 0.001), with equivalent changes between ACL-injury models despite different injury mechanisms and adjacent meniscal damage. These findings suggest that despite the important role of joint injury; sex- and model-specific differences in ptOA progression and severity are not primarily driven by altered anterior-posterior knee biomechanics.
AbstractList Sex and joint injury are risk factors implicated in the onset and progression of osteoarthritis (OA). In mouse models of post-traumatic OA (ptOA), the pathogenesis of disease is notably impacted by sex (often worse in males) and injury model (e.g. meniscal versus ligament injury). Increasing ptOA progression and severity is often associated with greater relative instability of the joint but few studies have directly quantified changes in joint mechanics after injury and compared outcomes across multiple models in both male and female mice. Passive anterior-posterior knee biomechanics were evaluated in 10-week-old, male and female C57BL/6J mice. PtOA injury models included destabilisation of the medial meniscus (DMM), anterior cruciate ligament transection (ACLT) or mechanical rupture (ACLR), and combined DMM and ACLT (DMM + ACLT). Sham operated and non-operated controls (NOC) were included for baseline comparisons. The test apparatus loaded hindlimbs at 60° flexion between ± 1 N at 0.5 mm/s (build specifications available for download: https://doi.org/10.17632/z754455x3c.1). Measures of joint laxity (range of motion, neutral zone) and stiffness were calculated. Joint laxity was comparable between male and female mice while joint stiffness was greater in females (P ≤ 0.002, correcting for body-mass and injury-model). Anterior-posterior joint mechanics were minimally altered by DMM but significantly affected by loss of the ACL (P < 0.001), with equivalent changes between ACL-injury models despite different injury mechanisms and adjacent meniscal damage. These findings suggest that despite the important role of joint injury; sex- and model-specific differences in ptOA progression and severity are not primarily driven by altered anterior-posterior knee biomechanics.
Sex and joint injury are risk factors implicated in the onset and progression of osteoarthritis (OA). In mouse models of post-traumatic OA (ptOA), the pathogenesis of disease is notably impacted by sex (often worse in males) and injury model (e.g. meniscal versus ligament injury). Increasing ptOA progression and severity is often associated with greater relative instability of the joint but few studies have directly quantified changes in joint mechanics after injury and compared outcomes across multiple models in both male and female mice.Passive anterior-posterior knee biomechanics were evaluated in 10-week-old, male and female C57BL/6J mice. PtOA injury models included destabilisation of the medial meniscus (DMM), anterior cruciate ligament transection (ACLT) or mechanical rupture (ACLR), and combined DMM and ACLT (DMM + ACLT). Sham operated and non-operated controls (NOC) were included for baseline comparisons. The test apparatus loaded hindlimbs at 60° flexion between ± 1 N at 0.5 mm/s (build specifications available for download: https://doi.org/10.17632/z754455x3c.1). Measures of joint laxity (range of motion, neutral zone) and stiffness were calculated.Joint laxity was comparable between male and female mice while joint stiffness was greater in females (P ≤ 0.002, correcting for body-mass and injury-model). Anterior-posterior joint mechanics were minimally altered by DMM but significantly affected by loss of the ACL (P < 0.001), with equivalent changes between ACL-injury models despite different injury mechanisms and adjacent meniscal damage. These findings suggest that despite the important role of joint injury; sex- and model-specific differences in ptOA progression and severity are not primarily driven by altered anterior-posterior knee biomechanics.
Sex and joint injury are risk factors implicated in the onset and progression of osteoarthritis (OA). In mouse models of post-traumatic OA (ptOA), the pathogenesis of disease is notably impacted by sex (often worse in males) and injury model (e.g. meniscal versus ligament injury). Increasing ptOA progression and severity is often associated with greater relative instability of the joint but few studies have directly quantified changes in joint mechanics after injury and compared outcomes across multiple models in both male and female mice. Passive anterior-posterior knee biomechanics were evaluated in 10-week-old, male and female C57BL/6J mice. PtOA injury models included destabilisation of the medial meniscus (DMM), anterior cruciate ligament transection (ACLT) or mechanical rupture (ACLR), and combined DMM and ACLT (DMM + ACLT). Sham operated and non-operated controls (NOC) were included for baseline comparisons. The test apparatus loaded hindlimbs at 60° flexion between ± 1 N at 0.5 mm/s (build specifications available for download: https://doi.org/10.17632/z754455x3c.1). Measures of joint laxity (range of motion, neutral zone) and stiffness were calculated. Joint laxity was comparable between male and female mice while joint stiffness was greater in females (P ≤ 0.002, correcting for body-mass and injury-model). Anterior-posterior joint mechanics were minimally altered by DMM but significantly affected by loss of the ACL (P < 0.001), with equivalent changes between ACL-injury models despite different injury mechanisms and adjacent meniscal damage. These findings suggest that despite the important role of joint injury; sex- and model-specific differences in ptOA progression and severity are not primarily driven by altered anterior-posterior knee biomechanics.
ArticleNumber 110152
Author Clarke, Elizabeth C.
Blaker, Carina L.
Ashton, Dylan M.
Doran, Nathan
Little, Christopher B.
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  givenname: Dylan M.
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  givenname: Nathan
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  givenname: Christopher B.
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  givenname: Elizabeth C.
  surname: Clarke
  fullname: Clarke, Elizabeth C.
  email: elizabeth.clarke@sydney.edu.au
  organization: Murray Maxwell Biomechanics Laboratory, Institute of Bone and Joint Research, Kolling Institute, Northern Sydney Local Health District, Faculty of Medicine and Health, University of Sydney, St. Leonards, New South Wales, Australia
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Cites_doi 10.1038/nrrheum.2013.72
10.1016/j.joca.2005.04.014
10.2106/JBJS.J.00150
10.1136/bjsports-2013-093258
10.1016/j.arthro.2007.07.003
10.1136/bjsports-2019-100959
10.3390/ijms21103696
10.1097/01.bot.0000246468.80635.ef
10.1002/art.33388
10.1152/japplphysiol.00620.2016
10.1016/j.joca.2019.11.003
10.1038/srep44315
10.1016/j.joca.2015.04.015
10.5694/mja17.00974
10.1080/17453670710013924
10.1055/s-0033-1341578
10.1080/03008207.2017.1284824
10.1016/0268-0033(95)92045-N
10.1002/jor.21549
10.1016/j.joca.2014.07.011
10.1016/0021-9290(95)00130-1
10.1016/j.bone.2012.03.025
10.1016/j.joca.2005.03.004
10.1016/j.ocarto.2020.100026
10.1016/j.injury.2008.06.021
10.1214/aos/1013699998
10.1038/nrrheum.2014.46
10.1002/jor.20398
10.1016/j.joca.2012.04.014
10.1177/0363546506286786
10.1177/0363546507307396
10.1152/physiolgenomics.00311.2004
10.1016/j.joca.2016.06.013
10.1016/j.exger.2012.11.008
10.1177/0363546511416597
10.1186/s13075-015-0747-6
10.1177/03635465030310061801
10.1002/jor.23418
10.1177/0363546511424720
10.1016/j.joca.2011.04.018
10.1016/j.joca.2006.11.005
10.1016/j.jsams.2008.07.005
10.1016/j.joca.2016.01.739
10.1016/j.joca.2018.06.017
10.2106/00004623-198466020-00011
10.1177/0363546512461744
10.1007/s00167-018-5180-3
10.1016/j.bone.2005.08.007
10.1002/jor.23322
10.3109/17453678008990887
10.1111/j.2517-6161.1995.tb02031.x
10.1002/art.34420
10.1016/j.joca.2015.02.165
10.1179/ptr.1997.2.4.217
10.2106/00004623-200201000-00002
10.1002/jor.23343
10.1136/bjsports-2019-100765
10.1002/jor.22480
10.1016/j.joca.2007.03.006
10.1016/j.joca.2015.11.005
10.1016/j.semarthrit.2019.09.018
10.1016/j.joca.2010.11.006
10.1016/S1063-4584(05)80088-3
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Keywords Non-invasive model
ACL
PTOA
DMM
Joint mechanics
Surgical model
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References Shultz, Shimokochi, Nguyen, Schmitz, Beynnon, Perrin (b0275) 2007; 25
Shultz, Pye, Montgomery, Schmitz (b0270) 2012; 40
Benjamini, Hochberg (b0025) 1995; Methodological
Lohmander, Englund, Dahl, Roos (b0200) 2007; 35
Snoeker, Turkiewicz, Magnusson, Frobell, Yu, Peat, Englund (b0280) 2020; 54
Maerz, Newton, Kurdziel, Altman, Anderson, Matthew, Baker (b0215) 2016; 24
Ma, Blanchet, Peluso, Hopkins, Morris, Glasson (b0205) 2007; 15
Blaker, Little, Clarke (b0050) 2017; 35
Contartese, Tschon, De Mattei, Fini (b0085) 2020; 21
Hayami, Pickarski, Zhuo, Wesolowski, Rodan, Duong (b0140) 2006; 38
Hayami, Zhuo, Wesolowski, Pickarski, Duong (b0145) 2012; 50
Wu, Kimmerling, Little, Guilak (b0330) 2017; 7
Temp, Labuz, Negrete, Sunkara, Machelska (b0290) 2020; 28
Gianotti, Marshall, Hume, Bunt (b0125) 2009; 12
Maitland, Bell, Mohtadi, Herzog (b0220) 1995; 10
Lee, Aadalen, Malaviya, Lorenz, Hayden, Farr, Kang, Cole (b0165) 2006; 34
Moodie, Stok, Muller, Vincent, Shefelbine (b0250) 2011; 19
van Osch, van der Kraan, Vitters, Blankevoort, van den Berg (b0315) 1993; 1
Dejour, Pungitore, Valluy, Nover, Saffarini, Demey (b0090) 2019; 27
Vincent (b0320) 2019; 49
Glasson, Little (b0130) 2011; 19
Satkunananthan, Anderson, De Jesus, Haudenschild, Ripplinger, Christiansen (b0260) 2014; 22
Blankevoort, van Osch, Janssen, Hekman (b0055) 1996; 29
Burleigh, Chanalaris, Gardiner, Driscoll, Boruc, Saklatvala, Vincent (b0065) 2012; 64
Iijima, Aoyama, Ito, Yamaguchi, Nagai, Tajino, Zhang, Kuroki (b0155) 2015; 23
[dataset] Blaker, C., Little, C., Clarke, E., 2020. Mouse Knee Embedding and Joint Laxity Tester CAD Files. Mendeley Data. V1. http://dx.doi.org/10.17632/z754455x3c.1
Li, G., Papannagari, R., Defrate, L.E., Doo Yoo, J., Eun Park, S., J Gill, T., 2007. The effects of ACL deficiency on mediolateral translation and varus–valgus rotation. Acta Orthopaedica 78, 355-360.
Lien-Iversen, Morgan, Jensen, Risberg, Engebretsen, Viberg (b0180) 2020; 54
van Osch, van der Kraan, Blankevoort, Huiskes, Van den Berg (b0310) 1996; 23
Malfait, Little (b0230) 2015; 17
Zbrojkiewicz, Vertullo, Grayson (b0335) 2018; 208
van Meer, Meuffels, van Eijsden, Verhaar, Bierma-Zeinstra, Reijman (b0305) 2015; 49
Hootman, Dick, Agel (b0150) 2007; 42
Markolf, Kochan, Amstutz (b0235) 1984; 66
Fryhofer, Freedman, Hillin, Salka, Pardes, Weiss, Farber, Soslowsky (b0115) 2016; 1985
Frank, Beveridge, Huebner, Heard, Tapper, O'Brien, Shrive (b0110) 2012; 30
Maitland, Kawchuk (b0225) 1997; 2
Glasson, Blanchet, Morris (b0135) 2007; 15
Schirwis, Agbulut, Vadrot, Mouisel, Hourdé, Bonnieu, Butler-Browne, Amthor, Ferry (b0265) 2013; 48
Tochigi, Vaseenon, Heiner, Fredericks, Martin, Rudert, Hillis, Brown, McKinley (b0295) 2011; 93
Consolino, Duclos, Lee, Williamson, Campbell, Brooks (b0080) 2005; 22
Ahn, Bae, Kang, Kang, Lee (b0010) 2011; 39
Andriacchi, Griffin, Loeser, Chu, Roos, Hawker, Erhart-Hledik, Fischer (b0015) 2020; 2
Lockwood, Chu, Anderson, Haudenschild, Christiansen (b0190) 2014; 32
Blaker, Clarke, Little (b0045) 2017; 35
Benjamini, Yekutieli (b0030) 2001; 29
Prodromos, Han, Rogowski, Joyce, Shi (b0255) 2007; 23
Brown, Johnston, Saltzman, Marsh, Buckwalter (b0060) 2006; 20
Fukubayashi, Kurosawa (b0120) 1980; 51
Srikanth, Fryer, Zhai, Winzenberg, Hosmer, Jones (b0285) 2005; 13
Melrose, Fuller, Little (b0245) 2017; 58
McCulloch, Shybut, Isamaily, Durrani, Gold, Noble, Lintner (b0240) 2013; 26
Christiansen, Anderson, Lee, Williams, Yik, Haudenschild (b0070) 2012; 20
Wojtys, Ashton-Miller, Huston (b0325) 2002; 84
Uhorchak, J.M., Scoville, C.R., Williams, G.N., Arciero, R.A., St. Pierre, P., Taylor, D.C., 2003. Risk Factors Associated with Noncontact Injury of the Anterior Cruciate Ligament: A Prospective Four-Year Evaluation of 859 West Point Cadets. Am. J. Sports Med. 31, 831-842.
Adebayo, Ko, Goldring, Goldring, Wright, van der Meulen (b0005) 2016
Little, Hunter (b0185) 2013; 9
Finch, Kemp, Clapperton (b0105) 2015; 23
Maerz, Kurdziel, Newton, Altman, Anderson, Matthew, Baker (b0210) 2016; 24
Clayton, Court-Brown (b0075) 2008; 39
Loeser, Olex, McNulty, Carlson, Callahan, Ferguson, Chou, Leng, Fetrow (b0195) 2012; 64
Barton, Shekarforoush, Heard, Sevick, Vakil, Atarod, Martin, Achari, Hart, Frank, Shrive (b0020) 2017; 35
Kamekura, Hoshi, Shimoaka, Chung, Chikuda, Yamada, Uchida, Ogata, Seichi, Nakamura, Kawaguchi (b0160) 2005; 13
Li, Lorenz, Xu, Harner, Fu, Irrgang (b0175) 2011; 39
Edd, Omoumi, Andriacchi, Jolles, Favre (b0095) 2018; 26
Fang, Beier (b0100) 2014; 10
Blaker, Little, Smith, Clarke (b0040) 2016; 24
Snoeker (10.1016/j.jbiomech.2020.110152_b0280) 2020; 54
Ahn (10.1016/j.jbiomech.2020.110152_b0010) 2011; 39
Finch (10.1016/j.jbiomech.2020.110152_b0105) 2015; 23
Tochigi (10.1016/j.jbiomech.2020.110152_b0295) 2011; 93
Blaker (10.1016/j.jbiomech.2020.110152_b0040) 2016; 24
Glasson (10.1016/j.jbiomech.2020.110152_b0130) 2011; 19
Andriacchi (10.1016/j.jbiomech.2020.110152_b0015) 2020; 2
Glasson (10.1016/j.jbiomech.2020.110152_b0135) 2007; 15
Ma (10.1016/j.jbiomech.2020.110152_b0205) 2007; 15
10.1016/j.jbiomech.2020.110152_b0035
Loeser (10.1016/j.jbiomech.2020.110152_b0195) 2012; 64
Little (10.1016/j.jbiomech.2020.110152_b0185) 2013; 9
Maerz (10.1016/j.jbiomech.2020.110152_b0210) 2016; 24
Burleigh (10.1016/j.jbiomech.2020.110152_b0065) 2012; 64
Benjamini (10.1016/j.jbiomech.2020.110152_b0025) 1995; Methodological
Maitland (10.1016/j.jbiomech.2020.110152_b0225) 1997; 2
Kamekura (10.1016/j.jbiomech.2020.110152_b0160) 2005; 13
Lohmander (10.1016/j.jbiomech.2020.110152_b0200) 2007; 35
Satkunananthan (10.1016/j.jbiomech.2020.110152_b0260) 2014; 22
Lockwood (10.1016/j.jbiomech.2020.110152_b0190) 2014; 32
Shultz (10.1016/j.jbiomech.2020.110152_b0270) 2012; 40
Fang (10.1016/j.jbiomech.2020.110152_b0100) 2014; 10
Melrose (10.1016/j.jbiomech.2020.110152_b0245) 2017; 58
Hootman (10.1016/j.jbiomech.2020.110152_b0150) 2007; 42
Srikanth (10.1016/j.jbiomech.2020.110152_b0285) 2005; 13
Lien-Iversen (10.1016/j.jbiomech.2020.110152_b0180) 2020; 54
Contartese (10.1016/j.jbiomech.2020.110152_b0085) 2020; 21
van Osch (10.1016/j.jbiomech.2020.110152_b0315) 1993; 1
Moodie (10.1016/j.jbiomech.2020.110152_b0250) 2011; 19
10.1016/j.jbiomech.2020.110152_b0170
Wu (10.1016/j.jbiomech.2020.110152_b0330) 2017; 7
Blaker (10.1016/j.jbiomech.2020.110152_b0045) 2017; 35
Consolino (10.1016/j.jbiomech.2020.110152_b0080) 2005; 22
Adebayo (10.1016/j.jbiomech.2020.110152_b0005) 2016
Lee (10.1016/j.jbiomech.2020.110152_b0165) 2006; 34
Maerz (10.1016/j.jbiomech.2020.110152_b0215) 2016; 24
Markolf (10.1016/j.jbiomech.2020.110152_b0235) 1984; 66
Fryhofer (10.1016/j.jbiomech.2020.110152_b0115) 2016; 1985
Shultz (10.1016/j.jbiomech.2020.110152_b0275) 2007; 25
Blaker (10.1016/j.jbiomech.2020.110152_b0050) 2017; 35
van Osch (10.1016/j.jbiomech.2020.110152_b0310) 1996; 23
van Meer (10.1016/j.jbiomech.2020.110152_b0305) 2015; 49
Fukubayashi (10.1016/j.jbiomech.2020.110152_b0120) 1980; 51
Hayami (10.1016/j.jbiomech.2020.110152_b0140) 2006; 38
Iijima (10.1016/j.jbiomech.2020.110152_b0155) 2015; 23
Prodromos (10.1016/j.jbiomech.2020.110152_b0255) 2007; 23
Schirwis (10.1016/j.jbiomech.2020.110152_b0265) 2013; 48
Hayami (10.1016/j.jbiomech.2020.110152_b0145) 2012; 50
McCulloch (10.1016/j.jbiomech.2020.110152_b0240) 2013; 26
Dejour (10.1016/j.jbiomech.2020.110152_b0090) 2019; 27
Barton (10.1016/j.jbiomech.2020.110152_b0020) 2017; 35
Clayton (10.1016/j.jbiomech.2020.110152_b0075) 2008; 39
Vincent (10.1016/j.jbiomech.2020.110152_b0320) 2019; 49
Zbrojkiewicz (10.1016/j.jbiomech.2020.110152_b0335) 2018; 208
Malfait (10.1016/j.jbiomech.2020.110152_b0230) 2015; 17
Brown (10.1016/j.jbiomech.2020.110152_b0060) 2006; 20
10.1016/j.jbiomech.2020.110152_b0300
Frank (10.1016/j.jbiomech.2020.110152_b0110) 2012; 30
Benjamini (10.1016/j.jbiomech.2020.110152_b0030) 2001; 29
Christiansen (10.1016/j.jbiomech.2020.110152_b0070) 2012; 20
Maitland (10.1016/j.jbiomech.2020.110152_b0220) 1995; 10
Edd (10.1016/j.jbiomech.2020.110152_b0095) 2018; 26
Blankevoort (10.1016/j.jbiomech.2020.110152_b0055) 1996; 29
Li (10.1016/j.jbiomech.2020.110152_b0175) 2011; 39
Gianotti (10.1016/j.jbiomech.2020.110152_b0125) 2009; 12
Temp (10.1016/j.jbiomech.2020.110152_b0290) 2020; 28
Wojtys (10.1016/j.jbiomech.2020.110152_b0325) 2002; 84
References_xml – volume: 15
  start-page: 1061
  year: 2007
  end-page: 1069
  ident: b0135
  article-title: The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse
  publication-title: Osteoarthritis and Cartilage
  contributor:
    fullname: Morris
– volume: 38
  start-page: 234
  year: 2006
  end-page: 243
  ident: b0140
  article-title: Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis
  publication-title: Bone
  contributor:
    fullname: Duong
– volume: 39
  start-page: 1338
  year: 2008
  end-page: 1344
  ident: b0075
  article-title: The epidemiology of musculoskeletal tendinous and ligamentous injuries
  publication-title: Injury
  contributor:
    fullname: Court-Brown
– volume: 10
  start-page: 413
  year: 2014
  end-page: 421
  ident: b0100
  article-title: Mouse models of osteoarthritis: modelling risk factors and assessing outcomes
  publication-title: Nat. Rev. Rheumatol.
  contributor:
    fullname: Beier
– volume: 19
  start-page: 163
  year: 2011
  end-page: 170
  ident: b0250
  article-title: Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilisation of the medial meniscus and increased joint laxity
  publication-title: Osteoarthritis and Cartilage
  contributor:
    fullname: Shefelbine
– volume: 10
  start-page: 93
  year: 1995
  end-page: 97
  ident: b0220
  article-title: Quantitative analysis of anterior cruciate ligament instability
  publication-title: Clin. Biomech.
  contributor:
    fullname: Herzog
– volume: 25
  start-page: 989
  year: 2007
  end-page: 996
  ident: b0275
  article-title: Measurement of varus-valgus and internal-external rotational knee laxities in vivo - Part II: Relationship with anterior-posterior and general joint laxity in males and females
  publication-title: J. Orthop. Res.
  contributor:
    fullname: Perrin
– volume: 23
  start-page: 1320
  year: 2007
  end-page: 1325
  ident: b0255
  article-title: A meta-analysis of the incidence of anterior cruciate ligament tears as a function of gender, sport, and a knee injury-reduction regimen
  publication-title: Arthroscopy
  contributor:
    fullname: Shi
– volume: 39
  start-page: 2187
  year: 2011
  end-page: 2193
  ident: b0010
  article-title: Longitudinal tear of the medial meniscus posterior horn in the anterior cruciate ligament-deficient knee significantly influences anterior stability
  publication-title: Am. J. Sports Med.
  contributor:
    fullname: Lee
– volume: 21
  start-page: 3696
  year: 2020
  ident: b0085
  article-title: Sex specific determinants in osteoarthritis: a systematic review of preclinical studies
  publication-title: Int. J. Mol. Sci.
  contributor:
    fullname: Fini
– volume: 17
  start-page: 1
  year: 2015
  end-page: 14
  ident: b0230
  article-title: On the predictive utility of animal models of osteoarthritis
  publication-title: Arthritis Res. Therapy
  contributor:
    fullname: Little
– volume: 35
  start-page: 1754
  year: 2017
  end-page: 1763
  ident: b0050
  article-title: Joint loads resulting in ACL rupture: Effects of age, sex, and body mass on injury load and mode of failure in a mouse model
  publication-title: J. Orthop. Res.
  contributor:
    fullname: Clarke
– volume: 54
  start-page: 592
  year: 2020
  end-page: 598
  ident: b0180
  article-title: Does surgery reduce knee osteoarthritis, meniscal injury and subsequent complications compared with non-surgery after ACL rupture with at least 10 years follow-up? A systematic review and meta-analysis
  publication-title: Br. J. Sports Med.
  contributor:
    fullname: Viberg
– volume: 23
  start-page: 1227
  year: 1996
  end-page: 1232
  ident: b0310
  article-title: Relation of ligament damage with site specific cartilage loss and osteophyte formation in collagenase induced osteoarthritis in mice
  publication-title: J. Rheumatology
  contributor:
    fullname: Van den Berg
– volume: 51
  start-page: 871
  year: 1980
  end-page: 879
  ident: b0120
  article-title: The contact area and pressure distribution pattern of the knee. A study of normal and osteoarthrotic knee joints
  publication-title: Acta Orthop. Scand.
  contributor:
    fullname: Kurosawa
– volume: 2
  start-page: 217
  year: 1997
  end-page: 226
  ident: b0225
  article-title: Towards the quantification of end-feel for the assessment of passive joint motion
  publication-title: Phys. Therapy Rev.
  contributor:
    fullname: Kawchuk
– volume: 48
  start-page: 183
  year: 2013
  end-page: 190
  ident: b0265
  article-title: The beneficial effect of myostatin deficiency on maximal muscle force and power is attenuated with age
  publication-title: Exp. Gerontol.
  contributor:
    fullname: Ferry
– volume: 30
  start-page: 384
  year: 2012
  end-page: 392
  ident: b0110
  article-title: Complete ACL/MCL deficiency induces variable degrees of instability in sheep with specific kinematic abnormalities correlating with degrees of early osteoarthritis
  publication-title: J. Orthop. Res.
  contributor:
    fullname: Shrive
– volume: 27
  start-page: 564
  year: 2019
  end-page: 572
  ident: b0090
  article-title: Preoperative laxity in ACL-deficient knees increases with posterior tibial slope and medial meniscal tears
  publication-title: Knee Surg. Sports Traumatol. Arthrosc.
  contributor:
    fullname: Demey
– volume: 23
  start-page: 1563
  year: 2015
  end-page: 1574
  ident: b0155
  article-title: Effects of short-term gentle treadmill walking on subchondral bone in a rat model of instability-induced osteoarthritis
  publication-title: Osteoarthritis and Cartilage
  contributor:
    fullname: Kuroki
– volume: 9
  start-page: 485
  year: 2013
  end-page: 497
  ident: b0185
  article-title: Post-traumatic osteoarthritis: from mouse models to clinical trials
  publication-title: Nat. Rev. Rheumatol.
  contributor:
    fullname: Hunter
– volume: 50
  start-page: 1250
  year: 2012
  end-page: 1259
  ident: b0145
  article-title: Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis
  publication-title: Bone
  contributor:
    fullname: Duong
– volume: 58
  start-page: 282
  year: 2017
  end-page: 294
  ident: b0245
  article-title: The biology of meniscal pathology in osteoarthritis and its contribution to joint disease: beyond simple mechanics
  publication-title: Connect. Tissue Res.
  contributor:
    fullname: Little
– volume: 20
  start-page: 773
  year: 2012
  end-page: 782
  ident: b0070
  article-title: Musculoskeletal changes following non-invasive knee injury using a novel mouse model of post-traumatic osteoarthritis
  publication-title: Osteoarthritis & Cartilage
  contributor:
    fullname: Haudenschild
– volume: 24
  start-page: S410
  year: 2016
  ident: b0040
  article-title: Models of injury and osteoarthritis: the role of impact severity and joint instability
  publication-title: Osteoarthritis and Cartilage
  contributor:
    fullname: Clarke
– volume: 28
  start-page: 475
  year: 2020
  end-page: 485
  ident: b0290
  article-title: Pain and knee damage in male and female mice in the medial meniscal transection-induced osteoarthritis
  publication-title: Osteoarthritis and Cartilage
  contributor:
    fullname: Machelska
– volume: 66
  start-page: 242
  year: 1984
  end-page: 252
  ident: b0235
  article-title: Measurement of knee stiffness and laxity in patients with documented absence of the anterior cruciate ligament
  publication-title: J. Bone Joint Surg. (Am. Volume)
  contributor:
    fullname: Amstutz
– volume: 20
  start-page: 739
  year: 2006
  end-page: 744
  ident: b0060
  article-title: Posttraumatic osteoarthritis: A first estimate of incidence, prevalence, and burden of disease
  publication-title: J. Orthop. Trauma
  contributor:
    fullname: Buckwalter
– volume: 29
  start-page: 1165
  year: 2001
  end-page: 1188
  ident: b0030
  article-title: The control of the false discovery rate in multiple testing under dependency
  publication-title: Ann. Statistics
  contributor:
    fullname: Yekutieli
– volume: Methodological
  start-page: 289
  year: 1995
  end-page: 300
  ident: b0025
  article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing
  publication-title: J. Roy. Stat. Soc. B
  contributor:
    fullname: Hochberg
– volume: 12
  start-page: 622
  year: 2009
  end-page: 627
  ident: b0125
  article-title: Incidence of anterior cruciate ligament injury and other knee ligament injuries: A national population-based study
  publication-title: J. Sci. Med. Sport
  contributor:
    fullname: Bunt
– volume: 22
  start-page: 1461
  year: 2014
  end-page: 1469
  ident: b0260
  article-title: In vivo fluorescence reflectance imaging of protease activity in a mouse model of post-traumatic osteoarthritis
  publication-title: Osteoarthritis and Cartilage
  contributor:
    fullname: Christiansen
– volume: 84
  start-page: 10
  year: 2002
  end-page: 16
  ident: b0325
  article-title: A gender-related difference in the contribution of the knee musculature to sagittal-plane shear stiffness in subjects with similar knee laxity
  publication-title: JBJS
  contributor:
    fullname: Huston
– volume: 26
  start-page: 1425
  year: 2018
  end-page: 1437
  ident: b0095
  article-title: Modeling knee osteoarthritis pathophysiology using an integrated joint system (IJS): a systematic review of relationships among cartilage thickness, gait mechanics, and subchondral bone mineral density
  publication-title: Osteoarthritis and Cartilage
  contributor:
    fullname: Favre
– volume: 32
  start-page: 79
  year: 2014
  end-page: 88
  ident: b0190
  article-title: Comparison of loading rate-dependent injury modes in a murine model of post-traumatic osteoarthritis
  publication-title: J. Orthop. Res.
  contributor:
    fullname: Christiansen
– volume: 35
  start-page: 424
  year: 2017
  end-page: 439
  ident: b0045
  article-title: Using mouse models to investigate the pathophysiology, treatment, and prevention of post-traumatic osteoarthritis
  publication-title: J. Orthop. Res.
  contributor:
    fullname: Little
– volume: 64
  start-page: 705
  year: 2012
  end-page: 717
  ident: b0195
  article-title: Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice
  publication-title: Arthritis Rheum.
  contributor:
    fullname: Fetrow
– volume: 49
  start-page: 975
  year: 2015
  end-page: 983
  ident: b0305
  article-title: Which determinants predict tibiofemoral and patellofemoral osteoarthritis after anterior cruciate ligament injury? A systematic review
  publication-title: Br. J. Sports Med.
  contributor:
    fullname: Reijman
– year: 2016
  ident: b0005
  article-title: Kinematics of meniscal- and ACL-transected mouse knees during controlled tibial compressive loading captured using roentgen stereophotogrammetry
  publication-title: J. Orthop. Res.
  contributor:
    fullname: van der Meulen
– volume: 22
  start-page: 244
  year: 2005
  end-page: 256
  ident: b0080
  article-title: Muscles of mice deficient in α-sarcoglycan maintain large masses and near control force values throughout the life span
  publication-title: Physiol. Genomics
  contributor:
    fullname: Brooks
– volume: 93
  start-page: 640
  year: 2011
  end-page: 647
  ident: b0295
  article-title: Instability dependency of osteoarthritis development in a rabbit model of graded anterior cruciate ligament transection
  publication-title: J. Bone Joint Surg. (Am. Volume)
  contributor:
    fullname: McKinley
– volume: 24
  start-page: 698
  year: 2016
  end-page: 708
  ident: b0210
  article-title: Subchondral and epiphyseal bone remodeling following surgical transection and noninvasive rupture of the anterior cruciate ligament as models of post-traumatic osteoarthritis
  publication-title: Osteoarthritis and Cartilage
  contributor:
    fullname: Baker
– volume: 208
  start-page: 354
  year: 2018
  end-page: 358
  ident: b0335
  article-title: Increasing rates of anterior cruciate ligament reconstruction in young Australians, 2000–2015
  publication-title: Med. J. Aust.
  contributor:
    fullname: Grayson
– volume: 54
  start-page: 725
  year: 2020
  end-page: 730
  ident: b0280
  article-title: Risk of knee osteoarthritis after different types of knee injuries in young adults: a population-based cohort study
  publication-title: Br. J. Sports Med.
  contributor:
    fullname: Englund
– volume: 34
  start-page: 1334
  year: 2006
  end-page: 1344
  ident: b0165
  article-title: Tibiofemoral contact mechanics after serial medial meniscectomies in the human cadaveric knee
  publication-title: Am. J. Sports Med.
  contributor:
    fullname: Cole
– volume: 26
  start-page: 363
  year: 2013
  end-page: 369
  ident: b0240
  article-title: The effect of progressive degrees of medial meniscal loss on stability after anterior cruciate ligament reconstruction
  publication-title: J. Knee Surg.
  contributor:
    fullname: Lintner
– volume: 24
  start-page: 1918
  year: 2016
  end-page: 1927
  ident: b0215
  article-title: Articular cartilage degeneration following anterior cruciate ligament injury: a comparison of surgical transection and noninvasive rupture as preclinical models of post-traumatic osteoarthritis
  publication-title: Osteoarthritis and Cartilage
  contributor:
    fullname: Baker
– volume: 1985
  start-page: 1106
  year: 2016
  end-page: 1114
  ident: b0115
  article-title: Postinjury biomechanics of Achilles tendon vary by sex and hormone status
  publication-title: J. Appl. Physiol.
  contributor:
    fullname: Soslowsky
– volume: 64
  start-page: 2278
  year: 2012
  end-page: 2288
  ident: b0065
  article-title: Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo
  publication-title: Arthritis Rheum.
  contributor:
    fullname: Vincent
– volume: 39
  start-page: 2595
  year: 2011
  end-page: 2603
  ident: b0175
  article-title: Predictors of radiographic knee osteoarthritis after anterior cruciate ligament reconstruction
  publication-title: Am. J. Sports Med.
  contributor:
    fullname: Irrgang
– volume: 35
  start-page: 1756
  year: 2007
  end-page: 1769
  ident: b0200
  article-title: The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis
  publication-title: Am. J. Sports Med.
  contributor:
    fullname: Roos
– volume: 49
  start-page: S36
  year: 2019
  end-page: S38
  ident: b0320
  article-title: Mechanoflammation in osteoarthritis pathogenesis
  publication-title: Seminars in Arthritis and Rheumatism
  contributor:
    fullname: Vincent
– volume: 1
  start-page: 171
  year: 1993
  end-page: 177
  ident: b0315
  article-title: Induction of osteoarthritis by intra-articular injection of collagenase in mice. Strain and sex related differences
  publication-title: Osteoarthritis and Cartilage
  contributor:
    fullname: van den Berg
– volume: 40
  start-page: 2836
  year: 2012
  end-page: 2844
  ident: b0270
  article-title: Associations between lower extremity muscle mass and multiplanar knee laxity and stiffness a potential explanation for sex differences in frontal and transverse plane knee laxity
  publication-title: Am. J. Sports Med.
  contributor:
    fullname: Schmitz
– volume: 29
  start-page: 799
  year: 1996
  end-page: 806
  ident: b0055
  article-title: In vitro laxity-testers for knee joints of mice
  publication-title: J. Biomech.
  contributor:
    fullname: Hekman
– volume: 7
  start-page: 44315
  year: 2017
  ident: b0330
  article-title: Serum and synovial fluid lipidomic profiles predict obesity-associated osteoarthritis, synovitis, and wound repair
  publication-title: Sci. Rep.
  contributor:
    fullname: Guilak
– volume: 13
  start-page: 769
  year: 2005
  end-page: 781
  ident: b0285
  article-title: A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis
  publication-title: Osteoarthritis and Cartilage
  contributor:
    fullname: Jones
– volume: 2
  year: 2020
  ident: b0015
  article-title: Bridging disciplines as a pathway to finding new solutions for osteoarthritis a collaborative program presented at the 2019 orthopaedic research society and the osteoarthritis research society international
  publication-title: Osteoarthritis and Cartilage Open
  contributor:
    fullname: Fischer
– volume: 35
  start-page: 454
  year: 2017
  end-page: 465
  ident: b0020
  article-title: Use of pre-clinical surgically induced models to understand biomechanical and biological consequences of PTOA development
  publication-title: J. Orthop. Res.
  contributor:
    fullname: Shrive
– volume: 13
  start-page: 632
  year: 2005
  end-page: 641
  ident: b0160
  article-title: Osteoarthritis development in novel experimental mouse models induced by knee joint instability
  publication-title: Osteoarthritis and Cartilage
  contributor:
    fullname: Kawaguchi
– volume: 19
  start-page: 1076
  year: 2011
  end-page: 1077
  ident: b0130
  article-title: The recent paper “Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilization of the medial meniscus and increased joint laxity”
  publication-title: Osteoarthritis and Cartilage
  contributor:
    fullname: Little
– volume: 23
  start-page: 1138
  year: 2015
  end-page: 1143
  ident: b0105
  article-title: The incidence and burden of hospital-treated sports-related injury in people aged 15+ years in Victoria, Australia, 2004–2010: a future epidemic of osteoarthritis?
  publication-title: Osteoarthritis and Cartilage
  contributor:
    fullname: Clapperton
– volume: 15
  start-page: 695
  year: 2007
  end-page: 700
  ident: b0205
  article-title: Osteoarthritis severity is sex dependent in a surgical mouse model
  publication-title: Osteoarthritis and Cartilage
  contributor:
    fullname: Glasson
– volume: 42
  start-page: 311
  year: 2007
  end-page: 319
  ident: b0150
  article-title: Epidemiology of collegiate injuries for 15 sports: summary and recommendations for injury prevention initiatives
  publication-title: J. Athletic Training
  contributor:
    fullname: Agel
– volume: 9
  start-page: 485
  year: 2013
  ident: 10.1016/j.jbiomech.2020.110152_b0185
  article-title: Post-traumatic osteoarthritis: from mouse models to clinical trials
  publication-title: Nat. Rev. Rheumatol.
  doi: 10.1038/nrrheum.2013.72
  contributor:
    fullname: Little
– volume: 13
  start-page: 769
  year: 2005
  ident: 10.1016/j.jbiomech.2020.110152_b0285
  article-title: A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis
  publication-title: Osteoarthritis and Cartilage
  doi: 10.1016/j.joca.2005.04.014
  contributor:
    fullname: Srikanth
– volume: 93
  start-page: 640
  year: 2011
  ident: 10.1016/j.jbiomech.2020.110152_b0295
  article-title: Instability dependency of osteoarthritis development in a rabbit model of graded anterior cruciate ligament transection
  publication-title: J. Bone Joint Surg. (Am. Volume)
  doi: 10.2106/JBJS.J.00150
  contributor:
    fullname: Tochigi
– volume: 49
  start-page: 975
  year: 2015
  ident: 10.1016/j.jbiomech.2020.110152_b0305
  article-title: Which determinants predict tibiofemoral and patellofemoral osteoarthritis after anterior cruciate ligament injury? A systematic review
  publication-title: Br. J. Sports Med.
  doi: 10.1136/bjsports-2013-093258
  contributor:
    fullname: van Meer
– volume: 23
  start-page: 1320
  year: 2007
  ident: 10.1016/j.jbiomech.2020.110152_b0255
  article-title: A meta-analysis of the incidence of anterior cruciate ligament tears as a function of gender, sport, and a knee injury-reduction regimen
  publication-title: Arthroscopy
  doi: 10.1016/j.arthro.2007.07.003
  contributor:
    fullname: Prodromos
– volume: 54
  start-page: 725
  year: 2020
  ident: 10.1016/j.jbiomech.2020.110152_b0280
  article-title: Risk of knee osteoarthritis after different types of knee injuries in young adults: a population-based cohort study
  publication-title: Br. J. Sports Med.
  doi: 10.1136/bjsports-2019-100959
  contributor:
    fullname: Snoeker
– volume: 21
  start-page: 3696
  year: 2020
  ident: 10.1016/j.jbiomech.2020.110152_b0085
  article-title: Sex specific determinants in osteoarthritis: a systematic review of preclinical studies
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms21103696
  contributor:
    fullname: Contartese
– volume: 20
  start-page: 739
  year: 2006
  ident: 10.1016/j.jbiomech.2020.110152_b0060
  article-title: Posttraumatic osteoarthritis: A first estimate of incidence, prevalence, and burden of disease
  publication-title: J. Orthop. Trauma
  doi: 10.1097/01.bot.0000246468.80635.ef
  contributor:
    fullname: Brown
– volume: 64
  start-page: 705
  year: 2012
  ident: 10.1016/j.jbiomech.2020.110152_b0195
  article-title: Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice
  publication-title: Arthritis Rheum.
  doi: 10.1002/art.33388
  contributor:
    fullname: Loeser
– ident: 10.1016/j.jbiomech.2020.110152_b0035
– volume: 1985
  start-page: 1106
  issue: 121
  year: 2016
  ident: 10.1016/j.jbiomech.2020.110152_b0115
  article-title: Postinjury biomechanics of Achilles tendon vary by sex and hormone status
  publication-title: J. Appl. Physiol.
  doi: 10.1152/japplphysiol.00620.2016
  contributor:
    fullname: Fryhofer
– volume: 23
  start-page: 1227
  year: 1996
  ident: 10.1016/j.jbiomech.2020.110152_b0310
  article-title: Relation of ligament damage with site specific cartilage loss and osteophyte formation in collagenase induced osteoarthritis in mice
  publication-title: J. Rheumatology
  contributor:
    fullname: van Osch
– volume: 28
  start-page: 475
  year: 2020
  ident: 10.1016/j.jbiomech.2020.110152_b0290
  article-title: Pain and knee damage in male and female mice in the medial meniscal transection-induced osteoarthritis
  publication-title: Osteoarthritis and Cartilage
  doi: 10.1016/j.joca.2019.11.003
  contributor:
    fullname: Temp
– volume: 7
  start-page: 44315
  year: 2017
  ident: 10.1016/j.jbiomech.2020.110152_b0330
  article-title: Serum and synovial fluid lipidomic profiles predict obesity-associated osteoarthritis, synovitis, and wound repair
  publication-title: Sci. Rep.
  doi: 10.1038/srep44315
  contributor:
    fullname: Wu
– volume: 23
  start-page: 1563
  year: 2015
  ident: 10.1016/j.jbiomech.2020.110152_b0155
  article-title: Effects of short-term gentle treadmill walking on subchondral bone in a rat model of instability-induced osteoarthritis
  publication-title: Osteoarthritis and Cartilage
  doi: 10.1016/j.joca.2015.04.015
  contributor:
    fullname: Iijima
– volume: 208
  start-page: 354
  year: 2018
  ident: 10.1016/j.jbiomech.2020.110152_b0335
  article-title: Increasing rates of anterior cruciate ligament reconstruction in young Australians, 2000–2015
  publication-title: Med. J. Aust.
  doi: 10.5694/mja17.00974
  contributor:
    fullname: Zbrojkiewicz
– ident: 10.1016/j.jbiomech.2020.110152_b0170
  doi: 10.1080/17453670710013924
– volume: 26
  start-page: 363
  year: 2013
  ident: 10.1016/j.jbiomech.2020.110152_b0240
  article-title: The effect of progressive degrees of medial meniscal loss on stability after anterior cruciate ligament reconstruction
  publication-title: J. Knee Surg.
  doi: 10.1055/s-0033-1341578
  contributor:
    fullname: McCulloch
– volume: 58
  start-page: 282
  year: 2017
  ident: 10.1016/j.jbiomech.2020.110152_b0245
  article-title: The biology of meniscal pathology in osteoarthritis and its contribution to joint disease: beyond simple mechanics
  publication-title: Connect. Tissue Res.
  doi: 10.1080/03008207.2017.1284824
  contributor:
    fullname: Melrose
– volume: 10
  start-page: 93
  year: 1995
  ident: 10.1016/j.jbiomech.2020.110152_b0220
  article-title: Quantitative analysis of anterior cruciate ligament instability
  publication-title: Clin. Biomech.
  doi: 10.1016/0268-0033(95)92045-N
  contributor:
    fullname: Maitland
– volume: 30
  start-page: 384
  year: 2012
  ident: 10.1016/j.jbiomech.2020.110152_b0110
  article-title: Complete ACL/MCL deficiency induces variable degrees of instability in sheep with specific kinematic abnormalities correlating with degrees of early osteoarthritis
  publication-title: J. Orthop. Res.
  doi: 10.1002/jor.21549
  contributor:
    fullname: Frank
– volume: 22
  start-page: 1461
  year: 2014
  ident: 10.1016/j.jbiomech.2020.110152_b0260
  article-title: In vivo fluorescence reflectance imaging of protease activity in a mouse model of post-traumatic osteoarthritis
  publication-title: Osteoarthritis and Cartilage
  doi: 10.1016/j.joca.2014.07.011
  contributor:
    fullname: Satkunananthan
– volume: 29
  start-page: 799
  year: 1996
  ident: 10.1016/j.jbiomech.2020.110152_b0055
  article-title: In vitro laxity-testers for knee joints of mice
  publication-title: J. Biomech.
  doi: 10.1016/0021-9290(95)00130-1
  contributor:
    fullname: Blankevoort
– volume: 50
  start-page: 1250
  year: 2012
  ident: 10.1016/j.jbiomech.2020.110152_b0145
  article-title: Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis
  publication-title: Bone
  doi: 10.1016/j.bone.2012.03.025
  contributor:
    fullname: Hayami
– volume: 13
  start-page: 632
  year: 2005
  ident: 10.1016/j.jbiomech.2020.110152_b0160
  article-title: Osteoarthritis development in novel experimental mouse models induced by knee joint instability
  publication-title: Osteoarthritis and Cartilage
  doi: 10.1016/j.joca.2005.03.004
  contributor:
    fullname: Kamekura
– volume: 2
  year: 2020
  ident: 10.1016/j.jbiomech.2020.110152_b0015
  article-title: Bridging disciplines as a pathway to finding new solutions for osteoarthritis a collaborative program presented at the 2019 orthopaedic research society and the osteoarthritis research society international
  publication-title: Osteoarthritis and Cartilage Open
  doi: 10.1016/j.ocarto.2020.100026
  contributor:
    fullname: Andriacchi
– volume: 39
  start-page: 1338
  year: 2008
  ident: 10.1016/j.jbiomech.2020.110152_b0075
  article-title: The epidemiology of musculoskeletal tendinous and ligamentous injuries
  publication-title: Injury
  doi: 10.1016/j.injury.2008.06.021
  contributor:
    fullname: Clayton
– volume: 29
  start-page: 1165
  year: 2001
  ident: 10.1016/j.jbiomech.2020.110152_b0030
  article-title: The control of the false discovery rate in multiple testing under dependency
  publication-title: Ann. Statistics
  doi: 10.1214/aos/1013699998
  contributor:
    fullname: Benjamini
– volume: 10
  start-page: 413
  year: 2014
  ident: 10.1016/j.jbiomech.2020.110152_b0100
  article-title: Mouse models of osteoarthritis: modelling risk factors and assessing outcomes
  publication-title: Nat. Rev. Rheumatol.
  doi: 10.1038/nrrheum.2014.46
  contributor:
    fullname: Fang
– volume: 25
  start-page: 989
  year: 2007
  ident: 10.1016/j.jbiomech.2020.110152_b0275
  article-title: Measurement of varus-valgus and internal-external rotational knee laxities in vivo - Part II: Relationship with anterior-posterior and general joint laxity in males and females
  publication-title: J. Orthop. Res.
  doi: 10.1002/jor.20398
  contributor:
    fullname: Shultz
– volume: 20
  start-page: 773
  year: 2012
  ident: 10.1016/j.jbiomech.2020.110152_b0070
  article-title: Musculoskeletal changes following non-invasive knee injury using a novel mouse model of post-traumatic osteoarthritis
  publication-title: Osteoarthritis & Cartilage
  doi: 10.1016/j.joca.2012.04.014
  contributor:
    fullname: Christiansen
– volume: 34
  start-page: 1334
  year: 2006
  ident: 10.1016/j.jbiomech.2020.110152_b0165
  article-title: Tibiofemoral contact mechanics after serial medial meniscectomies in the human cadaveric knee
  publication-title: Am. J. Sports Med.
  doi: 10.1177/0363546506286786
  contributor:
    fullname: Lee
– volume: 42
  start-page: 311
  year: 2007
  ident: 10.1016/j.jbiomech.2020.110152_b0150
  article-title: Epidemiology of collegiate injuries for 15 sports: summary and recommendations for injury prevention initiatives
  publication-title: J. Athletic Training
  contributor:
    fullname: Hootman
– volume: 35
  start-page: 1756
  year: 2007
  ident: 10.1016/j.jbiomech.2020.110152_b0200
  article-title: The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis
  publication-title: Am. J. Sports Med.
  doi: 10.1177/0363546507307396
  contributor:
    fullname: Lohmander
– volume: 22
  start-page: 244
  year: 2005
  ident: 10.1016/j.jbiomech.2020.110152_b0080
  article-title: Muscles of mice deficient in α-sarcoglycan maintain large masses and near control force values throughout the life span
  publication-title: Physiol. Genomics
  doi: 10.1152/physiolgenomics.00311.2004
  contributor:
    fullname: Consolino
– volume: 24
  start-page: 1918
  year: 2016
  ident: 10.1016/j.jbiomech.2020.110152_b0215
  article-title: Articular cartilage degeneration following anterior cruciate ligament injury: a comparison of surgical transection and noninvasive rupture as preclinical models of post-traumatic osteoarthritis
  publication-title: Osteoarthritis and Cartilage
  doi: 10.1016/j.joca.2016.06.013
  contributor:
    fullname: Maerz
– volume: 48
  start-page: 183
  year: 2013
  ident: 10.1016/j.jbiomech.2020.110152_b0265
  article-title: The beneficial effect of myostatin deficiency on maximal muscle force and power is attenuated with age
  publication-title: Exp. Gerontol.
  doi: 10.1016/j.exger.2012.11.008
  contributor:
    fullname: Schirwis
– volume: 39
  start-page: 2187
  year: 2011
  ident: 10.1016/j.jbiomech.2020.110152_b0010
  article-title: Longitudinal tear of the medial meniscus posterior horn in the anterior cruciate ligament-deficient knee significantly influences anterior stability
  publication-title: Am. J. Sports Med.
  doi: 10.1177/0363546511416597
  contributor:
    fullname: Ahn
– volume: 17
  start-page: 1
  year: 2015
  ident: 10.1016/j.jbiomech.2020.110152_b0230
  article-title: On the predictive utility of animal models of osteoarthritis
  publication-title: Arthritis Res. Therapy
  doi: 10.1186/s13075-015-0747-6
  contributor:
    fullname: Malfait
– ident: 10.1016/j.jbiomech.2020.110152_b0300
  doi: 10.1177/03635465030310061801
– volume: 35
  start-page: 1754
  year: 2017
  ident: 10.1016/j.jbiomech.2020.110152_b0050
  article-title: Joint loads resulting in ACL rupture: Effects of age, sex, and body mass on injury load and mode of failure in a mouse model
  publication-title: J. Orthop. Res.
  doi: 10.1002/jor.23418
  contributor:
    fullname: Blaker
– volume: 39
  start-page: 2595
  year: 2011
  ident: 10.1016/j.jbiomech.2020.110152_b0175
  article-title: Predictors of radiographic knee osteoarthritis after anterior cruciate ligament reconstruction
  publication-title: Am. J. Sports Med.
  doi: 10.1177/0363546511424720
  contributor:
    fullname: Li
– volume: 19
  start-page: 1076
  year: 2011
  ident: 10.1016/j.jbiomech.2020.110152_b0130
  article-title: The recent paper “Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilization of the medial meniscus and increased joint laxity”
  publication-title: Osteoarthritis and Cartilage
  doi: 10.1016/j.joca.2011.04.018
  contributor:
    fullname: Glasson
– volume: 15
  start-page: 695
  year: 2007
  ident: 10.1016/j.jbiomech.2020.110152_b0205
  article-title: Osteoarthritis severity is sex dependent in a surgical mouse model
  publication-title: Osteoarthritis and Cartilage
  doi: 10.1016/j.joca.2006.11.005
  contributor:
    fullname: Ma
– volume: 12
  start-page: 622
  year: 2009
  ident: 10.1016/j.jbiomech.2020.110152_b0125
  article-title: Incidence of anterior cruciate ligament injury and other knee ligament injuries: A national population-based study
  publication-title: J. Sci. Med. Sport
  doi: 10.1016/j.jsams.2008.07.005
  contributor:
    fullname: Gianotti
– volume: 24
  start-page: S410
  issue: Supplement 1
  year: 2016
  ident: 10.1016/j.jbiomech.2020.110152_b0040
  article-title: Models of injury and osteoarthritis: the role of impact severity and joint instability
  publication-title: Osteoarthritis and Cartilage
  doi: 10.1016/j.joca.2016.01.739
  contributor:
    fullname: Blaker
– volume: 26
  start-page: 1425
  year: 2018
  ident: 10.1016/j.jbiomech.2020.110152_b0095
  article-title: Modeling knee osteoarthritis pathophysiology using an integrated joint system (IJS): a systematic review of relationships among cartilage thickness, gait mechanics, and subchondral bone mineral density
  publication-title: Osteoarthritis and Cartilage
  doi: 10.1016/j.joca.2018.06.017
  contributor:
    fullname: Edd
– volume: 66
  start-page: 242
  year: 1984
  ident: 10.1016/j.jbiomech.2020.110152_b0235
  article-title: Measurement of knee stiffness and laxity in patients with documented absence of the anterior cruciate ligament
  publication-title: J. Bone Joint Surg. (Am. Volume)
  doi: 10.2106/00004623-198466020-00011
  contributor:
    fullname: Markolf
– volume: 40
  start-page: 2836
  year: 2012
  ident: 10.1016/j.jbiomech.2020.110152_b0270
  article-title: Associations between lower extremity muscle mass and multiplanar knee laxity and stiffness a potential explanation for sex differences in frontal and transverse plane knee laxity
  publication-title: Am. J. Sports Med.
  doi: 10.1177/0363546512461744
  contributor:
    fullname: Shultz
– volume: 27
  start-page: 564
  year: 2019
  ident: 10.1016/j.jbiomech.2020.110152_b0090
  article-title: Preoperative laxity in ACL-deficient knees increases with posterior tibial slope and medial meniscal tears
  publication-title: Knee Surg. Sports Traumatol. Arthrosc.
  doi: 10.1007/s00167-018-5180-3
  contributor:
    fullname: Dejour
– volume: 38
  start-page: 234
  year: 2006
  ident: 10.1016/j.jbiomech.2020.110152_b0140
  article-title: Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis
  publication-title: Bone
  doi: 10.1016/j.bone.2005.08.007
  contributor:
    fullname: Hayami
– volume: 35
  start-page: 454
  year: 2017
  ident: 10.1016/j.jbiomech.2020.110152_b0020
  article-title: Use of pre-clinical surgically induced models to understand biomechanical and biological consequences of PTOA development
  publication-title: J. Orthop. Res.
  doi: 10.1002/jor.23322
  contributor:
    fullname: Barton
– volume: 51
  start-page: 871
  year: 1980
  ident: 10.1016/j.jbiomech.2020.110152_b0120
  article-title: The contact area and pressure distribution pattern of the knee. A study of normal and osteoarthrotic knee joints
  publication-title: Acta Orthop. Scand.
  doi: 10.3109/17453678008990887
  contributor:
    fullname: Fukubayashi
– volume: Methodological
  start-page: 289
  year: 1995
  ident: 10.1016/j.jbiomech.2020.110152_b0025
  article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing
  publication-title: J. Roy. Stat. Soc. B
  doi: 10.1111/j.2517-6161.1995.tb02031.x
  contributor:
    fullname: Benjamini
– volume: 64
  start-page: 2278
  year: 2012
  ident: 10.1016/j.jbiomech.2020.110152_b0065
  article-title: Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo
  publication-title: Arthritis Rheum.
  doi: 10.1002/art.34420
  contributor:
    fullname: Burleigh
– volume: 23
  start-page: 1138
  year: 2015
  ident: 10.1016/j.jbiomech.2020.110152_b0105
  article-title: The incidence and burden of hospital-treated sports-related injury in people aged 15+ years in Victoria, Australia, 2004–2010: a future epidemic of osteoarthritis?
  publication-title: Osteoarthritis and Cartilage
  doi: 10.1016/j.joca.2015.02.165
  contributor:
    fullname: Finch
– volume: 2
  start-page: 217
  year: 1997
  ident: 10.1016/j.jbiomech.2020.110152_b0225
  article-title: Towards the quantification of end-feel for the assessment of passive joint motion
  publication-title: Phys. Therapy Rev.
  doi: 10.1179/ptr.1997.2.4.217
  contributor:
    fullname: Maitland
– volume: 84
  start-page: 10
  year: 2002
  ident: 10.1016/j.jbiomech.2020.110152_b0325
  article-title: A gender-related difference in the contribution of the knee musculature to sagittal-plane shear stiffness in subjects with similar knee laxity
  publication-title: JBJS
  doi: 10.2106/00004623-200201000-00002
  contributor:
    fullname: Wojtys
– year: 2016
  ident: 10.1016/j.jbiomech.2020.110152_b0005
  article-title: Kinematics of meniscal- and ACL-transected mouse knees during controlled tibial compressive loading captured using roentgen stereophotogrammetry
  publication-title: J. Orthop. Res.
  contributor:
    fullname: Adebayo
– volume: 35
  start-page: 424
  year: 2017
  ident: 10.1016/j.jbiomech.2020.110152_b0045
  article-title: Using mouse models to investigate the pathophysiology, treatment, and prevention of post-traumatic osteoarthritis
  publication-title: J. Orthop. Res.
  doi: 10.1002/jor.23343
  contributor:
    fullname: Blaker
– volume: 54
  start-page: 592
  year: 2020
  ident: 10.1016/j.jbiomech.2020.110152_b0180
  article-title: Does surgery reduce knee osteoarthritis, meniscal injury and subsequent complications compared with non-surgery after ACL rupture with at least 10 years follow-up? A systematic review and meta-analysis
  publication-title: Br. J. Sports Med.
  doi: 10.1136/bjsports-2019-100765
  contributor:
    fullname: Lien-Iversen
– volume: 32
  start-page: 79
  year: 2014
  ident: 10.1016/j.jbiomech.2020.110152_b0190
  article-title: Comparison of loading rate-dependent injury modes in a murine model of post-traumatic osteoarthritis
  publication-title: J. Orthop. Res.
  doi: 10.1002/jor.22480
  contributor:
    fullname: Lockwood
– volume: 15
  start-page: 1061
  year: 2007
  ident: 10.1016/j.jbiomech.2020.110152_b0135
  article-title: The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse
  publication-title: Osteoarthritis and Cartilage
  doi: 10.1016/j.joca.2007.03.006
  contributor:
    fullname: Glasson
– volume: 24
  start-page: 698
  year: 2016
  ident: 10.1016/j.jbiomech.2020.110152_b0210
  article-title: Subchondral and epiphyseal bone remodeling following surgical transection and noninvasive rupture of the anterior cruciate ligament as models of post-traumatic osteoarthritis
  publication-title: Osteoarthritis and Cartilage
  doi: 10.1016/j.joca.2015.11.005
  contributor:
    fullname: Maerz
– volume: 49
  start-page: S36
  issue: 3S
  year: 2019
  ident: 10.1016/j.jbiomech.2020.110152_b0320
  article-title: Mechanoflammation in osteoarthritis pathogenesis
  publication-title: Seminars in Arthritis and Rheumatism
  doi: 10.1016/j.semarthrit.2019.09.018
  contributor:
    fullname: Vincent
– volume: 19
  start-page: 163
  year: 2011
  ident: 10.1016/j.jbiomech.2020.110152_b0250
  article-title: Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilisation of the medial meniscus and increased joint laxity
  publication-title: Osteoarthritis and Cartilage
  doi: 10.1016/j.joca.2010.11.006
  contributor:
    fullname: Moodie
– volume: 1
  start-page: 171
  year: 1993
  ident: 10.1016/j.jbiomech.2020.110152_b0315
  article-title: Induction of osteoarthritis by intra-articular injection of collagenase in mice. Strain and sex related differences
  publication-title: Osteoarthritis and Cartilage
  doi: 10.1016/S1063-4584(05)80088-3
  contributor:
    fullname: van Osch
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Snippet Sex and joint injury are risk factors implicated in the onset and progression of osteoarthritis (OA). In mouse models of post-traumatic OA (ptOA), the...
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SubjectTerms ACL
Animal models
Animals
Anterior cruciate ligament
Arthritis
Biomechanics
Biomedical materials
DMM
Females
Injuries
Joint and ligament injuries
Joint mechanics
Joints (anatomy)
Knee
Ligaments
Meniscus
Non-invasive model
Osteoarthritis
Pathogenesis
PTOA
Risk analysis
Risk factors
Sex
Stiffness
Surgical model
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Title Sex- and injury-based differences in knee biomechanics in mouse models of post-traumatic osteoarthritis
URI https://dx.doi.org/10.1016/j.jbiomech.2020.110152
https://www.ncbi.nlm.nih.gov/pubmed/33285491
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