Low-dose tacrolimus combined with donor-derived mesenchymal stem cells after renal transplantation: a prospective, non-randomized study

• Published in: Oncotarget Vol. 7; no. 11; pp. 12089 - 12101
• Main Authors: Pan, Guang-hui, Chen, Zheng, Xu, Lu, Zhu, Jing-hui, Xiang, Peng, Ma, Jun-jie, Peng, Yan-wen, Li, Guang-hui, Chen, Xiao-yong, Fang, Jia-li, Guo, Yu-he, Zhang, Lei, Liu, Long-shan
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 15.03.2016
• Subjects: Adult; Female; Graft Rejection - prevention & control; Graft Survival - drug effects; Humans; Immunosuppressive Agents - administration & dosage; Kidney Transplantation - methods; Male; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal Stromal Cells - cytology; Pilot Projects; Prospective Studies; Research Paper: Pathology; Tacrolimus - administration & dosage; graft survival; Pathology Section; acute rejection; nephrotoxicity; mesenchymal stem cells (MSCs); calcineurin inhibitors

Calcineurin inhibitors, including tacrolimus, are largely responsible for advances in allotransplantation. However, the nephrotoxicity associated with these immunosuppressants impairs patients' long-term survival after renal allograft. Therefore, novel regimens that minimize or even eliminate c...