Multilevel-analysis identify a cis -expression quantitative trait locus associated with risk of renal cell carcinoma

• Published in: Oncotarget Vol. 6; no. 6; pp. 4097 - 4109
• Main Authors: Shu, Xiang, Purdue, Mark P., Ye, Yuanqing, Wood, Christopher G., Chen, Meng, Wang, Zhaoming, Albanes, Demetrius, Pu, Xia, Huang, Maosheng, Stevens, Victoria L., Diver, W. Ryan, Gapstur, Susan M., Virtamo, Jarmo, Chow, Wong-Ho, Tannir, Nizar M., Dinney, Colin P., Rothman, Nathaniel, Chanock, Stephen J., Wu, Xifeng
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 28.02.2015
• Subjects: Carcinoma, Renal Cell - genetics; Case-Control Studies; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Kidney Neoplasms - genetics; Male; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Research Paper

We conducted multilevel analyses to identify potential susceptibility loci for renal cell carcinoma (RCC), which may be overlooked in traditional genome-wide association studies (GWAS). A gene set enrichment analysis was performed utilizing a GWAS dataset comprised of 894 RCC cases and 1,516 control...