Daptomycin Versus Vancomycin for Bloodstream Infections Due to Methicillin-Resistant Staphylococcus aureus With a High Vancomycin Minimum Inhibitory Concentration: A Case-Control Study

• Published in: Clinical infectious diseases Vol. 54; no. 1; pp. 51 - 58
• Main Authors: Moore, Carol L., Osaki-Kiyan, Paola, Haque, Nadia Z., Perri, Mary Beth, Donabedian, Susan, Zervos, Marcus J.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.01.2012
• Subjects: Adult; Aged; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - adverse effects; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; ARTICLES AND COMMENTARIES; Bacteremia; Bacteremia - drug therapy; Bacteremia - microbiology; Bacterial diseases; Bacterial infections; Bacterial sepsis; Biological and medical sciences; Blood; Case-Control Studies; Comparative analysis; Daptomycin - administration & dosage; Daptomycin - adverse effects; Daptomycin - pharmacology; Drug resistance; Drug therapy; Endocarditis; Female; Health outcomes; Human bacterial diseases; Humans; Infections; Infectious diseases; Male; Medical sciences; Methicillin resistant staphylococcus aureus; Methicillin-Resistant Staphylococcus aureus - isolation & purification; Microbial Sensitivity Tests; Middle Aged; Mortality; Pharmacology. Drug treatments; Retrospective Studies; Staphylococcal Infections - drug therapy; Staphylococcal Infections - microbiology; Staphylococcal infections, streptococcal infections, pneumococcal infections; Staphylococcus aureus; Staphylococcus infections; Treatment Outcome; Vancomycin - administration & dosage; Vancomycin - adverse effects; Vancomycin - pharmacology; Peptides; Daptomycin; Case control study; Vancomycin; Bacteremia; Infection; Antibiotic; Glycopeptide; Polypeptide; Minimum inhibitory concentration; Bacteriosis; Bacteria; Micrococcales; Micrococcaceae; Antibacterial agent; Staphylococcal infection; Lipopeptide; Comparative study; Staphylococcus aureus

Background. Reports have found a link between vancomycin treatment failure in methicillin-resistant Staphyloccocus aureus (MRSA) bloodstream infections (BSIs) and higher vancomycin minimum inhibitory concentrations (MICs), despite MICs being below the susceptibility breakpoint of 2 µg/mL. Consensus...